Subjects: Library Science，Information Science >> Library Science submitted time 2023-07-26 Cooperative journals: 《图书情报工作》
Abstract： [Purpose/significance] Information quality is an important premise for platform to improve competitive advantage and sustainable development. The free and open spirit of academic social networking sites causes obstacles to information quality control. Therefore, it is necessary to optimize and improve information quality through analysis of key elements.[Method/process] Based on the previous research work, an information quality governance decision-making model of academic social networking sites is constructed, which composed by four dimensions of control rules, platform technology, information content and information users; based on the DEMETAL method, each impact strategy is identified and analyzed to determine the key strategies affecting the information quality of academic social networking sites.[Result/conclusion] Through data analysis, five important conclusions are sorted out, two management inspirations and implementation steps are summarized, which can overcome the subjective assumptions in qualitative research and provide practical references for human-computer interaction, quality control and service design of academic social networking sites' platform.
Subjects: Geosciences >> Hydrology submitted time 2023-04-07 Cooperative journals: 《干旱区地理》
Abstract： This study takes the grain and cotton cropping systems as an example to measure the development level of the water resource and agricultural cropping systems in Xinjiang, China to study its water resource endowment and agriculture industry development, respectively. Additionally, the two systems are combined to further analyze the coupling coordination and spatiotemporal differences of the water resources- agriculture cropping composite system (abbreviated composite system) in Xinjiang. Therefore, data related to water resources and agriculture cropping of 14 prefectures in Xinjiang from 2005 to 2019 were selected to measure the comprehensive development index of water resources, agriculture cropping, and composite systems using the entropy method. On the basis of the comprehensive development index of the composite system, this study further explores the coupling coordination trend and spatiotemporal evolution law of the composite system using the coupling coordination degree model and exploratory spatial data analysis, respectively. The following results are presented. (1) The comprehensive development index of the composite system in Xinjiang is spatially characterized by“high in the middle and low on both sides”. Among them, the level of comprehensive development index of the water resources system is higher than that of the agriculture cropping system and the growth trend of the agricultural plantation system is fast. Comparing the results of the composite development index of water resources and agriculture cropping systems from 2005 to 2019, this study found that the former has been developing at a higher level than the latter during the study period. However, the latter showed a faster growth trend than the former, resulting in a gradual reduction in the gap between the two systems. (2) The overall level of coupling coordination of composite systems in Xinjiang shows a development trend of“high in the north and low in the south, but the gap is gradually decreasing”. Additionally, the agriculture cropping system has gradually become a shortcoming that hinders the development of the coupling coordination of composite systems due to the differences among regions. (3) A significant spatial clustering characteristic of the coupling coordination degree of the composite system is also observed in Xinjiang, but its positive correlation shows a changing trend from strong to weak. The spatial clustering type is mainly“high-high and low-low”clustering, and the coupling coordination degree of the composite system shows spillover effects and is easily influenced by the neighboring areas. The results of this study have theoretical and practical implications for the sustainable use of water resources, the development of the agriculture cropping industry, and the benign coordination of the two in Xinjiang.
Subjects: Library Science，Information Science >> Information Science submitted time 2023-04-01 Cooperative journals: 《图书情报工作》
Abstract： [Purpose/significance] This study aims to explore the formation mechanism of the elderly's negative use of online health information services, and to provide reference and suggestions for the operation and management of online health platform.[Method/process] Using the "Cognition-Affect-Conation" paradigm, combined the cognitive load theory and the perceived value theory, this study explored the mechanism of anxiety and avoidance and withdrawal behaviors of elderly users of online health platform, and explained the influence mechanism between the elderly's perception of emotion, expression of emotion and negative behavior results.[Result/conclusion] The results showed that the perceived cost, information overload and service overload have obvious positive effects on the anxiety of the elderly, and the anxiety causes the negative use behavior intention of the elderly to avoid and quit, while the perceived risk and system overload have no significant effects on the anxiety of the elderly.
Subjects: Library Science，Information Science >> Information Science submitted time 2023-04-01 Cooperative journals: 《图书情报工作》
Abstract： [Purpose/significance] General readers encounter barriers in reading Chinese ancient books (CABs) caused by problems of access restrictions, ancient Chinese comprehension, professional knowledge, specific culture background in which they were written, and insufficient motivations of reading CABs. This research aims to use Virtual Reality (VR) technology to resolve (or mitigate) these barriers in order to promote CAB reading and culture dissemination.[Method/process] This research firstly analyzed theories in the filed of cognitive science and education technology through literature review, and then proposed VR CAB design principles and theoretical model. The VR CAB prototype is based on one case study research was developed and tested by laboratory test. A filed experiment was undertaken to evaluated VR CAB to proof the usefulness of design principles and theoretical model.[Result/conclusion] The contributions of this research are:①the design principles for VR CAB system; ②a theoretical model for the VR CAB system; ③the first ever prototype of a VR CAB system; ④the theory of using the VR CAB design. These contributions are very helpful for both academic researchers wanting to enter this complex interdisciplinary field as well as industry and practitioners wanting to apply these models on commercial applications.
Subjects: Other Disciplines >> Synthetic discipline submitted time 2023-03-31 Cooperative journals: 《农业图书情报学报》
Abstract： [Purpose/Significance] Chinese ancient books are one of the most important carriers to condense the essence of Chinese traditional culture. However, scholars have found that the database of Chinese ancient books only provides book metadata, which can only meet the basic retrieval and use needs of users, but does not dig and utilize Chinese ancient books in depth from the perspective of knowledge organization. The research in digital humanities is in the ascendant, providing an important modern scientific and technological means for the realization of knowledge correlation of Chinese ancient books. The research on the content mining and knowledge correlation of Chinese ancient books will help to improve the development level and service quality of Chinese ancient books, and promote the creative transformation and innovative development of Chinese excellent traditional culture. [Method/Process] Through literature review and online investigation, this paper summarizes the research of Chinese ancient books' knowledge correlation from the perspective of digital humanities. Based on the research, this paper discusses the differences between traditional database and digital humanistic platforms of Chinese ancient books. First, the organization mechanism is different, and the latter has more diverse and in-depth functions. Second, the scope of collection is expanded. The latter includes not only the original documents, but also the analytical texts and extended documents of ancient books, etc. In the past, most database platforms were "digital" platforms; The digital humanistic platform of Chinese ancient books is a platform of "data", which has been upgraded from "storage" to "analysis" and "correlation". Then, the key links of Chinese ancient books' knowledge correlation are discussed, and the barriers of knowledge correlation are analyzed by examples. [Results/Conclusions] From the perspective of digital humanities, collation of Chinese ancient books has developed from document units to knowledge units by using the data analysis technology, machine learning, visualization technology, etc. The realization of knowledge correlation of Chinese ancient books starts from document organization, based on ancient book data, and its essence is knowledge organization. Knowledge correlation of Chinese ancient books can be used for local chronicles and genealogy mining, seal knowledge network discovery, research context and communication analysis of scholars in specific periods and regions. However, the current knowledge correlation of ancient books still faces barriers such as the difficulty of knowledge element processing, high technical requirements and the lack of integrated platforms in its implementation. Limited by the research conditions, this paper only discusses the research and application, key links and barriers of ancient books' knowledge correlation from a theoretical point of view. In the future work, we will take the opportunity of optimizing and upgrading our ancient books' knowledge platform, to further study the metadata description specification, text conversion and content mining of Chinese ancient books, data exchange and update mechanism among different platforms.
Subjects: Psychology >> Social Psychology submitted time 2023-03-28 Cooperative journals: 《心理科学进展》
Abstract： Maintaining optimal hand hygiene is an important strategy for infection control and prevention. However, how to increase adherence to hand hygiene practices has been a major challenge to prevent infectious diseases and reduce hospital acquired infections (HAIs), especially in the critical period of COVID-19 epidemic regular prevention and control. There are great differences in the effectiveness between different hand hygiene behavior intervention strategies, and the best hand hygiene intervention practice is still in development and requires further investigation. In order to develop intervention strategies for health care researchers and practitioners, the current research systematically summarizes hand hygiene behavior intervention strategies from the perspective of “nudge” for the first time. Traditional hand hygiene interventions are usually based on knowledge sharing and health education, which only produce weak or modest effects on hand hygiene practices. Recent research in behavioral science provides insights for developing effective behavioral interventions to optimize hand hygiene practices by helping people form better hand hygiene habits. Traditional intervention strategies tend to rely on people’s ability to engage in rational thinking and the availability of cognitive resources, that is, encouraging people to reflect on their hand hygiene behaviors and enhance their handwashing motivation in a rational and conscious way. The influences of external environmental factors are rarely taken into account in traditional intervention strategies. Similarly, the role of personal psychological factors is often ignored, so this kind of hand hygiene intervention strategy often shows limited effectiveness and low sustainability. In addition, there are many other common obstacles such as limited accessibility of hand hygiene products, people's overconfidence in their immune system to prevent infection, inertia, and habitual forgetting. Many research results show that even if traditional intervention strategies can increase risk awareness of poor hand hygiene and enhance hand washing intention in the target population, they may not lead to effective behavior changes in hand hygiene. Inspired by the research from behavioral sciences, researchers have tried to promote experiential, unconscious, and automatically triggered hand hygiene behavior through interventions of specific psychological or external environmental factors, so as to help people overcome the gap between hand washing intention and behaviors. Based on different influential mechanisms, hand hygiene nudging strategies can be classified into four categories and nine subordinate categories, including providing decision information (simplifying information, providing feedback, and harvesting the impact of social norms), optimizing decision options (simplifying options and making original options more attractive), influencing decision structure (increasing the accessibility and visibility of favorable options), and reminding decision direction (direct reminder and environmental hint). Previous studies have shown that behavioral science-based hand hygiene interventions, in general, achieved positive effects at a fairly low cost, which are worthy of further application. However, there are still many disputes concerning ethics and effectiveness for nudging intervention. Among these disputes, the two points often mentioned are whether nudging limits the decision-makers' freedom of independent choice and damages their ability of independent choice. These two disputes may have a relatively small impact on hand hygiene promotion, and the form of nudging intervention is more easily accepted by the public, which may be due to the fact that handwashing behavior essentially has a certain degree of “injunctive norm” tendency (i.e., the vast majority of people agree with maintaining hand hygiene). In addition, previous research on hand hygiene nudging intervention also has many limitations, including low accuracy of the evaluation criteria, sustainability, and generalizability of nudging strategies. Further research is warranted to develop more effective hand hygiene nudging interventions and apply them to diverse social contexts. The effectiveness of multi-facet nudging strategies has also been confirmed in hand hygiene practices, suggesting that another future research direction is to construct a hand hygiene nudging strategy classification system similar to the Behavior Change Technique (BCT) taxonomy, so as to design multi-facet nudging strategies for promoting hand hygiene in a specific social context. Based on China's national conditions, traditional hand hygiene intervention strategies such as health education cannot be completely abandoned. This kind of comprehensive new model of “traditional intervention + nudging strategies” and the personalization and specialization of nudging intervention strategies might be the focus of hand hygiene behavior promotion intervention in the future. However, there is still a lack of hand hygiene nudging intervention in Chinese sociocultural contexts. Another direction for future research is to carry out such nudging interventions in hospitals, schools, communities, and other public places based on the theory of behavioral change, so as to contribute to the prevention and control of infectious diseases and improve public health.
Subjects: Psychology >> Social Psychology submitted time 2023-03-28 Cooperative journals: 《心理科学进展》
Abstract： Smoking is one of the major public health challenges around the world. Traditional tobacco control strategies, which include health education, taxes on tobacco products, and restrictions on smoking in public spaces, have greatly contributed to the reduction of smoking behavior around the world. However, these strategies are not always effective in helping smokers successfully quit smoking. As the traditional strategies do not consider the “irrational characteristics” of smoking behavior and its underlying mechanisms, their effects are usually discounted in real-world contexts. Recent advances in applied behavioral sciences during the past several decades provide new approaches for nudging smokers to quit smoking, which could be used to develop more effective tobacco control strategies at both the individual and population level. This article systematically reviews recent empirical research on behavioral intervention strategies to nudge smoking cessation according to the framework developed by Duckworth and colleagues for improving self-control. Specifically, behavioral nudge interventions for promoting smoking cessation could be classified by the people or organization implementing the intervention (e.g., smokers versus governments and public health agencies) and their underlying mechanisms (e.g., cognitively oriented versus context oriented). Context oriented interventions implemented by governments and public health agencies include reducing the accessibility of tobacco retail outlets in residence areas, restricting the display of tobacco products in stores and supermarkets, so as to reduce exposure of tobacco products, offering smaller size of cigarette products, and establishing separate smoking areas and removing tobacco-related irritants from the environment; cognitively oriented interventions implemented by governments and public health agencies include printing prominent warning pictures on cigarette packets, removing marketing information from cigarette packs, and increasing the usage of smoking cessation services; context oriented interventions implemented by smokers include making a public commitment to stop smoking and inviting important others to monitor one's smoking behavior, using loss aversion to motivate quitting behavior among smokers; cognitively oriented interventions implemented by smokers include making specific, actionable smoking cessation programs, promoting a future-oriented time perspective, and cultivating incremental theories of smoking behavior. This framework makes it easier for governments and smokers to select appropriate behavioral nudge interventions. It also has implications for informing the development of culturally sensitive and adaptive behavioral intervention strategies for promoting smoking cessation in China, improving the efficiency and effectiveness of smoking cessation interventions, and contributing to the achievement of the “Tobacco Control Initiatives” of the “Healthy China2030 Initiatives”. Although there is progress in developing effective behavioral nudge interventions for smoking cessation, future research is warranted to comprehensively evaluate the effects of these interventions, including both positive and negative effects, short-term and long-term effects, especially in real-world contexts. Future research is also needed to adopt behavioral change strategies in the development of stop-smoking APPs and digital smoking cessation services. By fully understanding the irrational characteristics of smoking behavior and its underlying mechanisms, we can develop tailored, targeted, context adaptable, and applicable smoking cessation intervention strategies. These types of interventions can greatly increase the effectiveness and efficiency of smoking cessation services. Future research is also needed to preclude the negative impacts of e-cigarettes and prevent the misuse of these behavior nudge strategies, especially among young children and adolescents who are vulnerable to the attraction of e-cigarettes. We believe that behavior science-informed interventions, if successfully implemented with the collaboration of governments, public health agencies, and smokers, can greatly contribute to safeguarding the health of both smokers and the general public.
submitted time 2023-03-25 Cooperative journals: 《心理科学进展》
Abstract： Smoking is one of the major public health challenges around the world. Traditional tobacco control strategies, which include health education, taxes on tobacco products, and restrictions on smoking in public spaces, have greatly contributed to the reduction of smoking behavior around the world. However, these strategies are not always effective in helping smokers successfully quit smoking. As the traditional strategies do not consider the “irrational characteristics” of smoking behavior and its underlying mechanisms, their effects are usually discounted in real-world contexts. Recent advances in applied behavioral sciences during the past several decades provide new approaches for nudging smokers to quit smoking, which could be used to develop more effective tobacco control strategies at both the individual and population level. This article systematically reviews recent empirical research on behavioral intervention strategies to nudge smoking cessation according to the framework developed by Duckworth and colleagues for improving self-control. Specifically, behavioral nudge interventions for promoting smoking cessation could be classified by the people or organization implementing the intervention (e.g., smokers versus governments and public health agencies) and their underlying mechanisms (e.g., cognitively oriented versus context oriented). Context oriented interventions implemented by governments and public health agencies include reducing the accessibility of tobacco retail outlets in residence areas, restricting the display of tobacco products in stores and supermarkets, so as to reduce exposure of tobacco products, offering smaller size of cigarette products, and establishing separate smoking areas and removing tobacco-related irritants from the environment; cognitively oriented interventions implemented by governments and public health agencies include printing prominent warning pictures on cigarette packets, removing marketing information from cigarette packs, and increasing the usage of smoking cessation services; context oriented interventions implemented by smokers include making a public commitment to stop smoking and inviting important others to monitor one's smoking behavior, using loss aversion to motivate quitting behavior among smokers; cognitively oriented interventions implemented by smokers include making specific, actionable smoking cessation programs, promoting a future-oriented time perspective, and cultivating incremental theories of smoking behavior. This framework makes it easier for governments and smokers to select appropriate behavioral nudge interventions. It also has implications for informing the development of culturally sensitive and adaptive behavioral intervention strategies for promoting smoking cessation in China, improving the efficiency and effectiveness of smoking cessation interventions, and contributing to the achievement of the “Tobacco Control Initiatives” of the “Healthy China2030 Initiatives”. Although there is progress in developing effective behavioral nudge interventions for smoking cessation, future research is warranted to comprehensively evaluate the effects of these interventions, including both positive and negative effects, short-term and long-term effects, especially in real-world contexts. Future research is also needed to adopt behavioral change strategies in the development of stop-smoking APPs and digital smoking cessation services. By fully understanding the irrational characteristics of smoking behavior and its underlying mechanisms, we can develop tailored, targeted, context adaptable, and applicable smoking cessation intervention strategies. These types of interventions can greatly increase the effectiveness and efficiency of smoking cessation services. Future research is also needed to preclude the negative impacts of e-cigarettes and prevent the misuse of these behavior nudge strategies, especially among young children and adolescents who are vulnerable to the attraction of e-cigarettes. We believe that behavior science-informed interventions, if successfully implemented with the collaboration of governments, public health agencies, and smokers, can greatly contribute to safeguarding the health of both smokers and the general public.
Subjects: Nursing >> Nursing submitted time 2022-09-06
Abstract：
Traditional Chinese medicine shi fu has been widely used in clinical practice, which is a common method for external treatment of Chinese medicine. Through literature review, this paper summarized the definition, historical origin and mechanism of TCM shi fu, and summarized the specific application of TCM shi fu from two aspects of cold and hot shi fu, providing reference for clinical research.
Subjects: Management Science >> Other Disciplines of Management Science submitted time 2022-04-22
Abstract：
"This paper formally proposes the new theoretical system of knowledge economics. Knowledge economics studies the law that knowledge creates economic value, and is a discipline that studies the effective use and allocation of resources and generates economic value on the basis of nearly infinite growth of data resources. Knowledge economics abandons the assumption of "limited resources" in traditional economics, and explores the laws of resource utilization, resource allocation, and resource creation on the basis of nearly unlimited data resources. Knowledge economics has its own research paradigm, research framework and corresponding basic problems. Based on the different perspectives of the status of data resources, knowledge economics covers the link economy stage, the digital economy stage and the knowledge economy stage. This paper also gives some specific examples, related methods and roles of knowledge-based economics corresponding to the research issues, making it clear that knowledge-based economy is the development direction of the economic system, and at the same time, it is given that the knowledge-based economy in finance is financial technology.
"
Peer Review Status:
Awaiting Review
Subjects: Psychology >> Medical Psychology submitted time 2021-11-24
Abstract： Maintaining optimal hand hygiene is an important strategy for infection control and prevention, but how to increase adherence to hand hygiene practices has been a major challenge to prevent infectious diseases and reduce hospital acquired infections (HAIs). Hand hygiene nudging intervention based on behavioral science transforms hand washing behavior into an automatic triggering habit in a more “imperceptible” way, which makes up for many limitations of traditional hand hygiene intervention based on knowledge sharing and health education. Given on different influential mechanisms, hand hygiene nudging strategies can be classified into four categories: providing decision information, optimizing decision options, influencing decision structure and reminding decision direction. The effectiveness of multi-facet nudging strategies has also been confirmed in practice, but there is still a lack of hand hygiene nudging intervention in Chinese sociocultural contexts. The future direction is to carry out such nudging interventions in hospitals, schools, communities and other public places in China based on the theory of behavioral sciences, so as to contribute to the prevention and control of infectious diseases and improve public health. "
Peer Review Status:Awaiting Review
Subjects: Medicine, Pharmacy >> Clinical Medicine submitted time 2019-11-15 Cooperative journals: 《协和医学杂志》
Abstract：患者男性，87岁，主诉“皮疹1月余，胸闷伴少尿11天”，于2019年4月29日收住北京协和医院老年医学科。
Subjects: Mathematics >> Computational Mathematics. submitted time 2019-08-27
Abstract： A generalized conjugate gradient method is proposed to solve eigenvalue problems. This method is designed by combining the dumping block inverse power scheme, subspace projection method. Furthermore, based on the properties of the proposed method, a series of optimization techniques is developed to improve the stability, computing efficiency and scalability. We also introduce a computing package GCGE (Generalized Conjugate Gradient Eigensolver) which is developed based on the proposed method here. Some numerical examples are provided to validate the stability, computing efficiency and scalability of the method in this paper. The corresponding computing package can be downloaded from the web site: https://github.com/pase2017/GCGE-1.0.
Peer Review Status:Awaiting Review
Subjects: Psychology >> Developmental Psychology submitted time 2019-06-21
Abstract： " That sleep quality could affect individual’s risk-taking behavior has been largely confirmed and supported by a growing body of research. It has been revealed that sleep loss affects not only the functional integrity of the frontal cortex, but also the activation of the amygdala and striatum brain regions, ultimately increasing individuals’ risk-taking behavior by decreasing their perception of danger and sensitivity to loss. However, previous studies have mostly focused on adult populations and neglected the interaction effect of personality traits and social environment on the relationship between sleep quality and risk-taking behavior. Moreover, due to the prevalence of sleep deprivation and high-risk-taking behavior in adolescents, the implications of further studies to understand these dynamics—especially the neural processing involved—in this population are addressed.
Subjects: Biology >> Zoology submitted time 2018-12-24 Cooperative journals: 《动物营养学报》
Abstract：本试验旨在研究断奶日龄对湖羊羔羊瘤胃微生物多样性的影响。选择66只湖羊公羔，在羔羊1、14、28日龄各屠宰6只羔羊，剩余48只羔羊随机分为2组，分别于28和56日龄断奶，在42、56、70和84日龄每组屠宰6只羔羊，取瘤胃内容物样品。所有羔羊7 日龄开始饲喂开食料。试验期为羔羊1~84日龄。结果表明：断奶日龄对白色瘤胃球菌（Ruminococcus albus）、黄色瘤胃球菌（Ruminococcus flavefaciens）、牛链球菌（Streptococcus bovis）、产琥珀酸丝状杆菌（Fibrobacter succinogenes）和布氏密螺旋体（Treponema bryantii）的相对丰度无显著影响（P>0.05）。随着日龄增加，羔羊瘤胃微生物多样性不断增加，28日龄断奶的羔羊相对56日龄断奶的羔羊其瘤胃微生物多样性提高。结果提示，瘤胃微生物多样性受日龄和断奶日龄的影响，早期断奶可加速瘤胃微生物区系的建立。
Subjects: Biology >> Bioengineering submitted time 2018-06-27 Cooperative journals: 《中国生物工程杂志》
Abstract： 利用甘油醛三磷酸脱氢酶（glyceraldehydes-3-phosphatedehydrogenase，GAP）启动子在毕赤酵母中表达人鹅型溶菌酶2（human goose-type lysozyme 2，hLysG2），并在小试规模建立一套有效的重组hLysG2（recombinant hLysG2，rhLysG2）生产工艺流程。根据毕赤酵母密码子偏爱性设计并人工合成hLysG2基因，将其连接至pGAPZA 质粒中，构建重组表达质粒pGAPZA-hLysG2。将重组表达载体线性化后电转化毕赤酵母GS115感受态细胞，通过Zeocin抗性筛选获取高拷贝重组菌株，并在5L生物反应器中进行发酵培养。发酵60 h后发酵液上清酶活性达到最高， 发酵液上清经SDS-PAGE及Western blot检测证实rhLysG2得到表达。与诱导型表达相比，组成型表达发酵时间缩短了48 h，上清中rhLysG2总活性提高了23.8%；使用甲壳素亲和层析和分子筛层析对rhLysG2进行纯化后，每升发酵液上清可纯化到187.4 mg重组蛋白，纯化产物纯度达99.0%以上；浊度测定法分析显示，在pH 5.6、30℃和0.1 mol/L Na+的条件下，rhLysG2可达到最大酶活性13500 U/mg。利用GAP启动子在毕赤酵母中成功表达了高纯度和高活性的rhLysG2，避免了甲醇的使用，缩短了发酵时间，提高了蛋白产量，为将rhLysG2开发为新型抗耐药菌药物奠定了基础。
Subjects: Medicine, Pharmacy >> Preclinical Medicine submitted time 2018-06-14 Cooperative journals: 《协和医学杂志》
Abstract： IgG4-related disease (IRD) is a newly defined multi-organ involved autoimmune disease only about 10 years ago. It is characterized by elevated serum IgG4, storiform fibrosis and massive infiltration of IgG4 positive plasma cells in involved organs. Biliary tract is one of the most common involved organs.IgG4-related sclerosing cholangitis (IRSC) is the clinical entity of IRD in biliary tract.It always has the similar clinical symptoms to biliary-pancreatic malignancy, such as localized biliary wall thickness, dilation of bile duct and obstructive jaundice. It is sensitive to steroids with satisfactory prognosis, which does not warrant surgical treatment. However, recent years, the authors met several cases who underwent operation due to bile duct stricture and obstructive jaundice. However, the final pathological examinations reported that they were IRSC. After reviewing these medical cases, the authors found IRSC was seldom considered before surgery. As well, there were some other cases of biliary malignancy with elevated serum IgG4 which were misdiagnosed to be IRS, leading to missing the best operative time. Therefore, to widely broadcast the knowledge of IRSC and especially to deepen the understanding of IRSC for the hepatic-biliary-pancreatic surgeons are of great clinical importance.
Subjects: Computer Science >> Integration Theory of Computer Science submitted time 2018-04-17 Cooperative journals: 《计算机应用研究》
Abstract： Faced with the problems often encountered in face detection under non-controlled conditions, such as complex facial expression, serious face occlusion, complex external environment, poor lighting conditions, tiny face, etc. A bottom-up face detection method is proposed. Bottom-up face detection is based on deep learning, face detection and key points of the first position-related key detection and then face detection. Convolution neural network structure using dense network for image feature extraction, the extracted features are transmitted to 6 cascaded networks, each of which consists of two branch networks. Branch network 1 is used to predict the coordinates of face-related key points. Branch network 2 is used to predict the position between key points relationship. Face detection is performed by using the obtained key point position and position relationship. The FDDB test set was verified and achieved 0.98 results, and the smallest face resolution #1; can be detected at the resolution of input image#1;, used the GPU Nvidia Geforce GTX 1070 for up to 17fps video detection.
Subjects: Biology >> Bioengineering submitted time 2018-01-12 Cooperative journals: 《中国生物工程杂志》
Abstract：对人源类溶菌酶蛋白6（human lysozyme-like protein 6，LYZL6）在受精过程中的作用进行研究，并对重组LYZL6蛋白（recombinant LYZL6，rLYZL6）的生理特性进行分析，从而揭示其生理功能。细胞免疫荧光法确定LYZL6定位于成熟精子头部的顶体后区域，反转录PCR（RT-PCR）分析表明精子表面的LYZL6蛋白来源于睾丸和附睾的分泌，Western blot法分析表明精子获能前后表面LYZL6的量无明显改变。半透明带结合实验和精子穿透实验分析表明兔抗LYZL6血清未明显抑制人精子结合透明带，但可明显抑制精卵融合。利用毕赤酵母表达系统成功表达了rLYZL6，使用甲壳素亲和层析和凝胶过滤层析可从发酵上清中纯化到具有生物活性的rLYZL6。酶联免疫吸附法（ELISA）分析显示rLYZL6不具有透明质酸结合能力、透明质酸水解能力和自由基清除活性，但具有较强的肽聚糖结合能力和异肽酶活性。LYZL6由睾丸和附睾分泌后定位于成熟精子头部的顶体后区域，可以参与精卵融合，并具有肽聚糖结合能力和异肽酶活性，提示LYZL6可能通过多种机制参与精子功能。
Subjects: Biology >> Bioengineering submitted time 2017-12-22 Cooperative journals: 《中国生物工程杂志》
Abstract：对人源类溶菌酶蛋白6（human lysozyme-like protein 6，LYZL6）在受精过程中的作用进行研究，并对重组LYZL6蛋白（recombinant LYZL6，rLYZL6）的生理特性进行分析，从而揭示其生理功能。细胞免疫荧光法确定LYZL6定位于成熟精子头部的顶体后区域，反转录PCR（RT-PCR）分析表明精子表面的LYZL6蛋白来源于睾丸和附睾的分泌，Western blot法分析表明精子获能前后表面LYZL6的量无明显改变。半透明带结合实验和精子穿透实验分析表明兔抗LYZL6血清未明显抑制人精子结合透明带，但可明显抑制精卵融合。利用毕赤酵母表达系统成功表达了rLYZL6，使用甲壳素亲和层析和凝胶过滤层析可从发酵上清中纯化到具有生物活性的rLYZL6。酶联免疫吸附法（ELISA）分析显示rLYZL6不具有透明质酸结合能力、透明质酸水解能力和自由基清除活性，但具有较强的肽聚糖结合能力和异肽酶活性。LYZL6由睾丸和附睾分泌后定位于成熟精子头部的顶体后区域，可以参与精卵融合，并具有肽聚糖结合能力和异肽酶活性，提示LYZL6可能通过多种机制参与精子
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