Subjects: Medicine, Pharmacy >> Clinical Medicine submitted time 2024-02-22 Cooperative journals: 《中国全科医学》
Abstract： Background Fibrinogen（FIB）is often elevated in children with Henoch Schonlein purpuric nephritis （HSPN），but the correlation between FIB and renal lesions has been less studied. Objective To explore the correlation between FIB in children with HSPN and the International Study Group on Pediatric Kidney Disease（ISKDC）pathology grading and micropathological changes in parts of renal units，and to clarify whether FIB can assess the severity of renal injury in children with HSPN. Methods In total，922 children with HSPN who were hospitalized in the First Affiliated Hospital of Henan University of Traditional Chinese Medicine in the pediatric nephrology ward and underwent kidney biopsy at the same time from December 2017 to December 2022 were collected，and the clinical information，FIB and renal pathological information during renal biopsy were summarized，and based on the FIB level，the children were categorized into group A（low）<2.38 g/L，group B（standard）2.38-4.98 g/L，and group C（high）>4.98 g/L. The correlation between FIB and ISKDC pathological grades， glomerular mesangial hyperplasia ratio，and the crescent ratio was investigated by Spearman rank correlation analysis，and the prediction of FIB on the micropathological changes of renal units was analyzed by the subject's work characteristic（ROC）curve. Results Among 922 children with HSPN who had undergone renal biopsy，the FIB was（3.48±1.01）g/L. 113 cases in group A had a low FIB rate of 12.26%；734 cases in group B had a standardized FIB rate of 79.61%；and 75 cases in group C had a high FIB rate of 8.13%. The ISKDC pathology classification was type Ⅱ a in 173 cases（18.76%），type Ⅱ b in 29 cases（3.15%）， 466 cases（50.54%）of type Ⅲ a，232 cases（25.16%）of type Ⅲ b，and 22 cases（2.39%）of type Ⅳ and above（including 2 cases of type Ⅳ a，18 cases of type Ⅳ b，and 2 cases of type Ⅴ）. The results of the Spearman's rank correlation analysis showed that the FIB and the grouping of the FIB of the children with HSPN were positively related to the renal pathology ISKDC grading（rs=0.146，P<0.001；rs=0.129，P<0.001）. 911（98.9%） of 922 children with HSPN were mesangial proliferative， and 655（71.04%）had crescentic hyperplasia. Spearman rank correlation analysis showed a weak positive correlation between FIB and FIB subgroups and the rate of mesangial hyperplasia（rs=0.092，P=0.005；rs=0.096，P=0.003），and a positive correlation with the rate of crescentic bodies（rs=0.132，P<0.001；rs=0.83，P=0.012）. 922 children with HSPN had glomerular acute lesions in 763 cases（82.75%），acute chronic lesions in 97 cases（10.52%），and chronic lesions in 62 cases （6.73%）. In addition，FIB gradually increased with the nature of the glomerular lesions from acute to chronic（rs=0.145， P<0.001）. At the same time，with renal biopsy，several index lesions（crescent body，mesangial hyperplasia，glomerular sclerosis，balloon adhesion，tubulinflammation or regeneration，tubular cell particle degeneration，tubular interstitial edema， tubular inflammatory cell infiltration，tubular atrophy，tubulointerstitial fibrosis，tubular lumen，and renal interstitial vascular abnormalities）in the comparison of the children's FIB were significantly correlated（P<0.05）.The ROC curves showed that the FIB had the highest sensitivity for glomerulosclerosis（sensitivity=0.900，specificity=0.303），and the optimal cutoff value for FIB was 2.835 mg/L；the area under the ROC curve（AUC）of FIB for the positive prediction of tubulointerstitial fibrosis=0.623，and that of FIB for the reverse prediction of tubulointerstitial cellular granulomatous degeneration=0.641. Conclusion FIB can be used as a laboratory index reflecting the severity of renal pathological changes in patients with HSPN， can indicate the severity of renal pathological grading，is closely related to irreversible lesions according to renal microscopic indicators such as glomerular sclerosis and balloon adhesion，and can be used to assist in clinical diagnosis and treatment.
Subjects: Biology >> Botany >> Applied botany submitted time 2024-02-07 Cooperative journals: 《广西植物》
Abstract： In this study, we sought to investigate the correlation between endophytic bacteria colonizing the leaves of Loropetalum chinense var. rubrum and the seasonal abnormal leaf coloration characteristic of this plant. Hence, we performed plate isolation and culturing and subsequent 16S rDNA sequence analysis to isolate and identify endophytic bacteria from leaves with five abnormal colors and normal red-colored leaves of L. chinense var. rubrum; we also analyzed differences in bacterial diversity, community structure, and functional levels among differently colored leaves. The results were as follows: (1) Compared with the normal red-colored leaves, we detected higher biomasses of endophytic bacteria in the five types of abnormally colored leaves. Among the isolated bacteria, 16S rDNA sequence alignment and phylo-genetic tree analysis revealed the presence of 906 bacterial strains classified into 26 genera and 40 species. (2) While the smaller leaves were colonized by the largest number of endophytic bacterial species with a relatively uniform community structure, the opposite was true for bacteria isolated from the redand yellow-pigmented leaves. (3) Comparison of the bacterial community data for abnormally colored leaves and those with the normal red color revealed that not only were there significant differences with respect to the dominant genera and species but also an enrichment of numerous bacterial species in the genera Methylobacterium and Pseudomonas in the five types of abnormally colored leaves. Particularly, we detected significantly larger numbers of Pseudomonas oryzihabitans. (4) We established that abnormally colored leaves (smaller, red spotted, and the red and yellow types) were characterized by an enrichment of bacteria with phosphorus solubilization, nitrogen fixation, IAA production, and salt tolerance functions, among which, four strains were found to have all four of these functions. Accordingly, we speculate that the abnormal leaf coloration of L. chinense var. rubrum is closely associated with the activities of these enriched functional bacteria. Our findings in this study indicate that the abnormal leaf coloration of L. chinense var. rubrum is closely associated with the enrichment of specific endophytic bacterial communities, which can thus provide clues for elucidating the mechanisms underlying the development of abnormal leaf pigmentation in this plant. Moreover, this may have important application value for the efficient cultivation of high-quality L. chinense var. rubrum.
Subjects: Medicine, Pharmacy >> Clinical Medicine submitted time 2024-02-05 Cooperative journals: 《中国全科医学》
Abstract： Background Nowadays，cardiac rehabilitation is mostly transferred from the hospital to a home environment. Mobile health applications assist patients in bridging the support gap from hospital to home environment，which encourages home-based recovery processes. Unfortunately，numerous quality difficulties accompany its promise，and the service quality of cardiac rehabilitation applications must be 〝confirmed〞 as soon as possible. Objective To develop a quality assessment indicator system for home-based rehabilitation APP services for heart failure patients，and to provide a model for standardizing and increasing the quality of mobile health APP. Methods This study was conducted from July 2022 to February 2023，using semi-structured interviews，literature review，the expert consultation method and analytic hierarchy process（AHP） to determine the content of indicator system and the weight for each index. Results 2 rounds of expert consultations resulted in the effective response rates of 100%，with the authority coefficients of 0.867，and the coordination coefficients of 0.128- 0.154 and 0.151-0.197 respectively（P<0.001）. As a result，an assessment indicator system for home-based rehabilitation APP services for heart failure patients was developed from three dimensions：software usability，medical professionalism，and behavioral science，with 7 primary indicators，24 secondary indicators，and 51 tertiary indicators. Conclusion The developedquality assessment indicator system for home-based rehabilitation APP services for heart failure patients is comprehensive and scientific，and can be useful for assessing and measuring the quality of heart rehabilitation APP services，as well as facilitating the benign development of similar APP services.
Subjects: Medicine, Pharmacy >> Preventive Medicine and Hygienics submitted time 2023-11-02 Cooperative journals: 《中国全科医学》
Abstract： Background Telerehabilitation based on digital medical care can efficiently improve the health status of patients after radiofrequency ablation of atrial fibrillation. However，the current participation rate in telerehabilitation is low. Objective To analyse the reasons for refusal of exercise rehabilitation in patients after radiofrequency ablation of atrial fibrillation in the context digital medical care based on the theory of leisure constraints. Methods Patients after radiofrequency ablation of atrial fibrillation in the inpatient department or outpatient clinic of cardiology at a tertiary-level hospital in Jiangsu Province from July 2022 to September 2022 were selected as the study subjects by using the purposive sampling method. The phenomenological approach was adopted to collect data from patients who refused exercise telerehabilitation after radiofrequency ablation through semi-structured interviews，and Colaizzi analysis was used to summarize the reasons. Results A total of 14 patients were finally included in this study. Three themes including self-limiting factors，interpersonal limiting factors，and structural limiting factors，and twelve sub-themes were extracted，namely，low level of digital literacy，negative illness perception，psychological distress caused by disease，digital medical trust crisis，deep-rooted personal exercise habits，alienation sense from rehabilitation team，insufficient social network establishment，economic burden related to equipment acquisition，harsh climate，low rehabilitation service capacity in primary care，constraints of available time by role pressure，and poor applicability of wearable devices. Conclusions The reasons for refusal to exercise telerehabilitation include lack of literacy and trust in digital medical care，high level of illness perception and psychological distress，poor exercise habits，rehabilitation team and peer alienation，economic burden，harsh climate，lack of capacity and personal time for rehabilitation service capacity in primary care，and inadequate applicability of existing wearable devices. It is necessary to build an effective support system and social network in exercise telerehabilitation on the basis of strengthening digital literacy and promoting mental recovery of patients in the future，strengthen the construction of the rehabilitation team to meet the requirements of digital medical care context，improve the treatment-rehabilitation-long-term care service chain centered on smart health and the reinforcement of rehabilitation service configuration in primary care，which is helpful to promote the participation of patients after radiofrequency ablation of atrial fibrillation in exercise telerehabilitation.
Subjects: Library Science，Information Science >> Information Science submitted time 2023-04-01 Cooperative journals: 《图书情报工作》
Abstract： [Purpose/significance] A good key technology identification method can provide better support for key technology identification, prediction and research and development at all levels. [Method/process] In this paper, a key technology identification method based on Bert-LDA was proposed, which combined BERT and LDA to make up for the lack of contextual semantic information in a single LDA topic model. An empirical study was carried out with agricultural robots as an example. Specifically, it included the following processes: ① Constructing BERT semantic feature vector and LDA topic feature vector based on Python, combining them in a high-dimensional space, and learning the low-dimensional latent space representation of the concatenated vector by using an autoencoder; ② In the potential space representation, K-means algorithm was used to realize semantic association clustering, and the effect diagram of two-dimensional clustering and key technology subject word cloud maps were drawn; ③ Determining key technologies; ④ In the field of agricultural robots, the effectiveness of this method was demonstrated by comparing with the results of TI patent analysis and the list of key generic technologies for agricultural equipments in the "Made in China 2025" technology roadmap for key areas. [Result/conclusion] The results show that the Bert-LDA model improves the coherence of topic clustering and the accuracy of fine-grained classification. With a good key technology identification accuracy and recall rate, there are good inclusiveness, compatibility and adaptability to the identified literature data sets of different databases and publishing types. It can be widely used to identify all kinds of key technologies.
Subjects: Psychology >> Social Psychology submitted time 2023-03-27 Cooperative journals: 《心理学报》
Abstract： Previous studies usually used the dynamic visual search paradigm to explore the Pip-and-Pop effect, which suggests that the Pip-and-Pop effect is influenced by multiple factors. But the impact of temporal and spatial consistency of audiovisual stimuli on the Pip-and-Pop effect is still controversial. In the present study, we applied the eye movement technology to the dynamic visual search paradigm to systematically investigate the impact of temporal and spatial consistency of audiovisual stimuli on the Pip-and-Pop effect. Based on the results of previous studies, we expected that the spatial and temporal consistency of audiovisual modulated the Pip-and-Pop effect. The more consistent the spatial location of audiovisual stimuli are, the greater the Pip-and-Pop effect will be. The more consistent the temporal audiovisual stimuli are, the greater the Pip-and-Pop effect will be. Experiment 1 was a 3 (set sizes: 36, 48, 60) � 4 (spatial consistency conditions: ipsilateral, contralateral, bilateral, no sound) within-subjects design, recruited 24 participants (5 males; age range: 19~28 years; mean age: 22.5 � 2.3 years). The visual search displays consisted of 24, 36, or 48 red (13.9 cd/m2) or green (46.4 cd/m2) line segments (0.57白0.17�) on a black (0.4 cd/m2) background. The auditory stimulus was 1000 Hz pure tone (65 dB, 60 ms, including 5 ms fade-in and 5 ms fade-out time), presented through speakers on the left and right sides behind the screen. Each trial started with a drift calibration point. The drift calibration point would not disappear until the participant gazed upon this point. This was followed by a central fixation point of 1000ms, and finally a search screen. The participants were required to find the target line segment and judge whether the target line segment was vertical or horizontal by pressing the key (Z key or M key) as quickly and accurately as possible. Experiment 2 was a 2 (set sizes: 36, 60) � 6 (temporal consistency conditions: -200 ms, -100 ms, 0 ms, 100 ms, 200 ms, no sound) within-subjects design, recruited 27 participants (5 males; age range: 18~25 years; mean age: 20.7 � 2.4 years). These temporal consistency conditions represent the tone sounded before (-200, -100 ms), simultaneous with (0 ms), or after (100, 200 ms) the visual target event. The tone could also be absent (no sound). The experimental materials and procedures of Experiment 2 were identical to those in Experiment1. Regarding the results in Experiment 1, compared with the baseline condition (no sound), the search response time was the shortest under the condition of ipsilateral, the mean fixation number was the least, and the mean saccade amplitude was the smallest, indicating that the search efficiency was the highest in the ipsilateral condition, the Pip-and-Pop effect was the largest in the ipsilateral condition. The bilateral condition was the second. The contralateral condition showed no significant difference in the above indicators compared with the no sound condition, indicating that no Pip-and-Pop effect was found in the contralateral condition. The results showed that the more consistent the spatial location of audiovisual stimuli were, the greater the Pip-and-Pop effect was. In Experiment 2, compared with the no sound condition, we found that the response time of the search was significantly shorter, the mean fixation number in search decreased, the mean saccade amplitude increased, and the mean fixation duration became longer under the conditions of 0 ms, -100 ms and 100 ms. Compared with the no sound condition, conditions -200 ms and 200 ms showed no significant difference in the above indicators. This indicated that the conditions of 0 ms, -100 ms and 100 ms produced the Pip-and-Pop effect, and the Pip-and-Pop effect was the largest under the condition of 0ms, while the Pip-and-Pop effect did not find under the condition of -200 ms and 200 ms. The results showed that the more consistent the temporal audiovisual stimuli were, the greater the Pip-and-Pop effect was. In summary, the results showed that the more consistent the audiovisual stimuli were in space and time, the larger the Pip-and-Pop effect was. Therefore, the findings in the present study suggest that the temporal and spatial consistency of audiovisual stimuli modulates the Pip-and-Pop effect. The results provide evidence that the reason for the Pip-and-Pop effect is multisensory integration.
Subjects: Psychology >> Cognitive Psychology submitted time 2022-06-14
Abstract：
Previous studies usually used the dynamic visual search paradigm to explore the Pip-and-Pop effect, which suggests that the Pip-and-Pop effect is influenced by multiple factors. But the impact of temporal and spatial consistency of audiovisual stimuli on the Pip-and-Pop effect is still controversial. In present study, we applied the eye movement technology to the dynamic visual search paradigm to systematically investigate the impact of temporal and spatial consistency of audiovisual stimuli on the Pip-and-Pop effect. Based on the results of previous studies, we expected that the spatial and temporal consistency of audiovisual modulated the Pip-and-Pop effect. The more consistent the spatial location of audiovisual stimuli are, the greater the Pip-and-Pop effect will be. The more consistent the temporal of audiovisual stimuli are, the greater the Pip-and-Pop effect will be.
Experiment 1 was a 3 (set sizes: 36, 48, 60) × 4 (spatial consistency conditions: ipsilateral, contralateral, bilateral, no sound) within-subjects design, recruited 24 participants(5 males; age range: 19–28 years; mean age: 22.5±2.3 years). The visual search displays consisted of 24, 36, or 48 red (13.9 cd/m2) or green (46.4 cd/m2) line segments (0.57°×0.17°) on a black (0.4cd/m2) background. Auditory stimulus was 1000Hz pure tone (65 dB, 60ms, including 5ms fade-in and 5ms fade-out time), presented through speakers on the left and right sides behind the screen. Each trial started with a drift calibration point. The drift calibration point would not disappear until the participant gazed upon this point. This was followed by a central fixation point of 1000ms, and finally a search screen. The participants were required to find the target line segment and judge whether the target line segment was vertical or horizontal by pressing the key (Z key or M key) as quickly and accurately as possible. Experiment 2 was a 2 (set sizes: 36, 60) × 6 (temporal consistency conditions: -200ms, -100ms, 0ms, 100ms, 200ms, no sound) within-subjects design, recruited 27 participants(5 males; age range: 18–25 years; mean age: 20.7±2.4 years). These temporal consistency conditions represent the tone sounded before ( -200, -100ms), simultaneous with (0ms), or after (100, 200ms) the visual target event. The tone could also be absent (no sound). The experimental materials and procedures of Experiment 2 were identical to those in Experiment1.
Regarding the results in Experiment 1, compared with the baseline condition (no sound), the search response time was the shortest under the condition of ipsilateral, the mean fixation number was the least, and the mean saccade amplitude was the smallest, indicating that the search efficiency was the highest in the ipsilateral condition, the Pip-and-Pop effect was the largest in the ipsilateral condition. Bilateral condition was the second. The contralateral condition showed no significant difference in the above indicators compared with the no sound condition, indicating that no Pip-and-Pop effect was found in the contralateral condition. The results showed that the more consistent the spatial location of audiovisual stimuli were, the greater the Pip-and-Pop effect was. In Experiment 2, compared with the no sound condition, we found that the response time of search was significantly shorter, the mean fixation number in search decreased, the mean saccade amplitude increased, and the mean fixation duration became longer under the conditions of 0ms, -100ms and 100ms. Compared with the no sound condition, conditions -200ms and 200ms showed no significant difference in the above indicators. This indicated that the conditions of 0ms, -100ms and 100ms produced Pip-and-Pop effect, and the Pip-and-Pop effect was the largest under the condition of 0ms, while Pip-and-Pop effect did not find under the condition of -200ms and 200ms. The results showed that the more consistent the temporal of audiovisual stimuli were, the greater the Pip-and-Pop effect was.
In summary, the results showed that the more consistent the audiovisual stimuli were in space and time, the larger the Pip-and-Pop effect was. Therefore, the findings in the present study suggest that the temporal and spatial consistency of audiovisual stimuli modulates the Pip-and-Pop effect. The results provide evidence that the reason for Pip-and-Pop effect is multisensory integration.
Peer Review Status:
Awaiting Review
Subjects: Medicine, Pharmacy >> Other Disciplines of Medicine and Pharmacology submitted time 2020-02-17
Abstract： "
Peer Review Status:Awaiting Review
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