Subjects: Medicine, Pharmacy >> Preventive Medicine and Hygienics submitted time 2024-07-17 Cooperative journals: 《中国全科医学》
Abstract： Background Systemic lupus erythematosus（SLE）is a chronic multisystem autoimmune disease. At present，three biological agents have been approved for treating SLE，including belimumab，anifrolumab，and telitacicept. However，a direct comparison of their efficacy and safety is lacked. Objective To analyze the clinical efficacy and safety of belimumab，anifrolumab，and telitacicept on the treatment of SLE using network meta-analysis. Methods Randomized controlled trials（RCTs）reporting belimumab，anifrolumab，and telitacicept to treat SLE were searched in the databases of PubMed，Web of Science，Cochrane Library，and Embase from the establishment of the databases until August 2023. After screening the relevant literatures and obtaining data from eligible RCTs based on the inclusion and exclusion criteria，direct or network meta-analysis was performed using the RevMan 5.4.1，R language 4.3.1，and Aggregate Data Drug Information System（ADDIS）1.16.8 software. Results After screening，4 789 SLE patients from 12 RCTs were included，including 2 721 patients in the experimental group and 2 068 patients in the placebo group. The direct meta-analysis results showed that the relief rate of SLE responder index 4（SRI4）in SLE patients treated with belimumab，anifrolumab，and telitacicept was significantly higher in the experimental group compared with that of the placebo group（OR=1.62，95%CI=1.40-1.88，P<0.001；OR=2.39，95%CI=1.70-3.37，P<0.001；OR=6.28，95%CI=3.20-12.33，P<0.001）. Compared with that of the placebo，the proportion of SLE patients with a reduced oral corticosteroid dosage after belimumab and anifrolumab treatment was significantly higher （OR=1.48，95%CI=1.09-2.02，P<0.001；OR=2.45，95% CI=1.69-3.54，P<0.001），and the severe recurrence（SR）rate was significantly lower（OR=0.59，95%CI=0.49-0.71，P<0.001；OR=0.52，95%CI=0.39-0.69，P<0.001）. The incidence of total adverse events（TAEs）of anifrolumab and telitacicept was significantly higher than that of the placebo group（OR=1.80，95%CI=1.25-2.59，P=0.001；OR=2.13，95%CI=1.18-3.83，P=0.01），while the incidence of serious adverse events（SAEs） of anifrolumab was significantly lower（OR=0.67，95%CI=0.46-0.97，P=0.04）.There were no significant differences in the incidence of TAEs（OR=0.89，95%CI=0.72-1.08，P=0.24）and SAEs（OR=0.82，95%CI=0.59-1.12，P=0.25）between the belimumab group and placebo group. The results of network Meta-analysis showed that the highest SRI4 was detected after the treatment of telitacicept，followed by anifrolumab，subcutaneous injection of belimumab and intravenous injection of belimumab. The highest incidence of TAEs was detected after the treatment of telitacicept，followed by anifrolumab，intravenous injection of belimumaband subcutaneous injection of belimumab. Conclusion Aelimumab，anifrolumab，and telitacicept all exhibit good clinical efficacy on the treatment of SLE，especially telitacicept. Although anifrolumab and telitacicept increase the overall incidence of TAEs after treatment，they reduce the incidence of SAEs. Of note，belimumab exhibits the highest safety on treating SLE.
Subjects: Medicine, Pharmacy >> Preventive Medicine and Hygienics submitted time 2024-07-17 Cooperative journals: 《中国全科医学》
Abstract： In children，autism spectrum disorder（ASD）is primarily characterized by social（communication） impairments and repetitive，stereotyped behaviors and restricted interests，affecting children's social interaction，communication abilities，and behavioral patterns. In recent years，with technological advancements，Digital Therapeutics has played a significant role in managing ASD. For instance，multimodal data integration and machine learning algorithms have been used for the early identification of ASD，while virtual reality，augmented reality，and gamified learning platforms have been widely applied to enhance the social skills and cognitive functions of children with ASD. Although digital therapy has shown great potential and benefits in the field of autism，it also faces challenges，including individual differences in treatment response，uncertainty of long-term effectiveness，and data privacy protection. Overall，Digital Therapeutics has opened up a new path for the management of autism，and also points out important directions for future research and applications.
Subjects: Medicine, Pharmacy >> Preventive Medicine and Hygienics submitted time 2024-07-17 Cooperative journals: 《中国全科医学》
WEN Yining1，2，3，4，HUANG Huichang1，3，4，5，ZHAO Mingming1，3，4*
WEN Yining1，2，3，4，HUANG Huichang1，3，4，5，ZHAO Mingming1，3，4*
WEN Yining1，2，3，4，HUANG Huichang1，3，4，5，ZHAO Mingming1，3，4*
Abstract： Subjective cognitive decline（SCD）usually predicts the risk of future cognitive decline，and sleep disturbances are very common in patients with SCD and often precede detectable cognitive changes. Although there is a lack of clarity regarding the relationship between sleep and SCD and the underlying mechanisms of sleep-related cognitive deterioration，studies in recent years have shown a strong link between sleep and cognitive decline. Cognitive decline may be triggered by either sleep deprivation or decreased sleep quality. Therefore，the aim of this review is to provide a comprehensive overview of the research progress on sleep and subjective cognitive decline，and to explore in depth the mechanism of their interaction，with a view to providing new ideas and methods for preventing and delaying cognitive decline，and providing useful references for research and practice in related fields.
Subjects: Medicine, Pharmacy >> Preventive Medicine and Hygienics submitted time 2024-07-17 Cooperative journals: 《中国全科医学》
Abstract： The concept landscape of frailty has evolved from a single dimension which emphasising predominantly physical frailty into a multidimensional concept encompassing physical，psychological and social frailty.Conducting researches on multidimensional frailty armong community-dwelling older adults is an important way to address the current fragmentation of community-based elderly care services and enhance the comprehensive health of this population. In this paper，firstly，we review the evolution of the concept of multidimensional frailty;secondly，classify and describe the multidi. mensional frailty assessment tools that can be applied to community-dwelling older adults;thirdly，analysis the influencing factors of multidimensional frailty in community-dwelling older adults as well as the interactions between the dimensions of frailty，finally，assess the predictive value of multidimensional frailty in community-dwelling older adults in relation to health outcomes. Existing evidences suggest that the multidimensional frailty is found to be the result of a combination of physiological，psychological，and social factors，and that assessing multidimensional frailty in community-dwelling older adults can predict a variety of health outcomes such as disability，disease risk，and mortality，and that the different dimensions of frailty are correlated and interact with each others.However，there is no a standardized tool for evaluating multidimensional frailty in the community-dwelling older adults，and the underlying mechanisms of its occurrence and development have not been clarified.So，the follow-up studies could explore the developmental trajectory of multidimensional debility based on large prospective cohort studies，in order to provide a referable basis for the development of intervention strategies to reverse or delay the frail process in community-dwelling older adults.
Subjects: Medicine, Pharmacy >> Clinical Medicine submitted time 2024-07-17 Cooperative journals: 《中国全科医学》
Abstract： Background The dual antiplatelet therapy of aspirin combined with ticagrelor is the preferred antiplatelet therapy for patients with ST segment elevation myocardial infarction （STEMI） who receive primary percutaneous coronary intervention（PPCI）. Compared with clopidogrel，ticagrelor can inhibit platelets faster and more effectively，and improve prognosis. However，there is still a lack of research on the application of reduced dose ticagrelor in STEMI patients receiving PPCI treatment. Objective To compare the different doses of ticagrelor on the efficacy and safety in patients with STEMI basedon propensity score matching（PSM）. Methods The patients with STEMI who underwent PPCI and antiplatelet therapy with ticagrelor at the Fifth Department of Cardiology，Second Hospital of Hebei Medical University from June 2019 to May 2021 were selected consecutively. According to the different maintenance doses of ticagrelor，patients were divided into a reduced dose group（n=60）and a standard group（n=180），using ticagrelor 60 mg/time（2 times/day）and 90 mg/time（2 times/ day），respectively. The PSM method was used to perform a 1:1 match between two groups，with matching variables including gender，age，medical history，Killip grade at admission，and intervention related parameters. Finally，54 patients were included in the each group. Follow-up was conducted on both groups at 1 month，3 months，and 6 months after discharge，and platelet parameters as well as clinical events were recorded and compared between the two groups of patients. Results There was no statistically significant difference in baseline data，intervention treatment parameters，and incidence of major adverse cardiovascular events（MACEs）during hospitalization between the two groups after PSM（P>0.05）. There was no statistically significant difference in the levels of platelet count（PLT），mean platelet volume（MPV），platelet distribution width（PDW）， and platelet aggregation rate（PAR）between baseline and 1 month after discharge（P>0.05）. The level of MPV in the reduced dose group was higher than that of the standard group at discharge，and the level of PDW was lower than that of the standard group（P<0.05）. The levlel of PDW in the reduction group was higher than that of the standard group after 3 months of discharge （P<0.05）. The level of MPV in the reduction group was higher than that of the standard group after 6 months of discharge （P<0.05）. There was no statistically significant difference in the level of PLT between the two groups before and after discharge （P>0.05）. The levels of MPV in the two groups were higher than baseline at discharge，while the levels of PDW and PAR were lower than baseline（P<0.05）. The level of MPV in the reduction group was lower than that at discharge at 1 month，3 months， and 6 months，while the levels of PDW and PAR were higher than those at discharge（P<0.05）. There was no statistically significant difference in the incidence of MACEs and severe bleeding events between the two groups during the follow-up（P>0.05）. Conclusion Reduced dose of ticagrelor treatment is safe and effective for STEMI patients undergoing PPCI.
Subjects: Digital Publishing >> New Media submitted time 2024-07-17 Cooperative journals: 《中国传媒科技》
Abstract：【目的】为探究其社交化阅读中的互动仪式建构及成效，为提升传统广电媒体的受众阅读体验，提升其全媒体传播实效提供镜鉴。【方法】以互动仪式链理论为理论基础，以微信读书APP为研究对象，以参与观察法和案例分析法为主要研究方法【结果】微信读书通过塑造虚拟共在场域、对局外人提前设限、以具体书目为共同焦点、通过个性化的情感与趣缘属性分享，构筑互动情境。【结论】提出塑造陪伴式阅读体验、构筑奖励性阅读情境、提供个性化阅读推荐等建议，面向未来电视与智能媒体时代，正视从情感联结出发维系受众阅读黏性，或许才是传统广电完善其数字化转型，推动其传播实效精准化、个性化的可行路径。
Subjects: Medicine, Pharmacy >> Clinical Medicine submitted time 2024-07-17 Cooperative journals: 《中国全科医学》
Abstract： Background Sepsis is a systemic inflammatory response caused by an imbalance of the host immune response to infectious factors，potentially leading to life-threatening organ dysfunction. The application of immature platelet fraction（IPF）to assessing the severity and prognosis of sepsis has been previously analyzed. However，the application of IPF combined with other biomarkers to predict sepsis has been rarely reported. Objective To explore the predictive value of IPF combined with other biomarkers in the severity and prognosis of sepsis. Methods A total of 60 sepsis patients admitted to the Department of Critical Care Medicine，Zhongshan Hospital，Fudan University（Xiamen Branch）from November 2020 to November 2022 were retrospectively recruited for analyzing their clinical data. Patients were classified into the severe sepsis group （n=24） and septic shock group （n=36） based on the severity of sepsis. Divided by the Sequential Organ Failure Assessment （SOFA） score，60 sepsis patients were assigned into the low SOFA group（SOFA score<6 points，n=26）and high SOFA group（SOFA score ≥ 6 points，n=34）. According to the outcome，there were 39 cases in the survival group and 21 cases in the death group. IPF and other blood indicators，including neutrophil to albumin ratio（NAR），platelet to lymphocyte ratio （PLR），neutrophil to lymphocyte ratio（NLR），and lactate to albumin ratio（LAR）were compared. The receiver operating characteristic（ROC）curves of IPF combined with other biomarkers for predicting the severity and prognosis of sepsis were plotted，and the area under the curve（AUC）was calculated. Results The proportion of lung diseases（66.7% vs. 35.9%）， baseline Acute Physiology and Chronic Health Evaluation Ⅱ（APACHE II）scores and baseline SOFA scores were significantly higher in the death group compared to those of the survival group（P<0.05）. Similarly，the proportion of lung diseases（61.8% vs. 26.9%），baseline APACHE II scores and mortality（50.0% vs. 15.4%）were significantly higher in the high SOFA group compared to those of the low SOFA group（P<0.05）. IPF at 48 hours of treatment was significantly higher in the septic shock group than that of the severe sepsis group，which was significantly higher in the high SOFA group compared to that of the low SOFA group，and significantly higher in the death group compared to that of the survival group（P<0.05）. Given the significant difference in 48-h IPF between groups，the laboratory indicators at this time point were selected for further research and analysis. The AUC of IPF in predicting septic shock，a high SOFA score and death was 0.70（cut-off value 3.95%，95% CI 0.55 to 0.83） and 0.72（cut-off value 7.70%，95% CI 0.60 to 0.86），0.73（cut-off value 7.70%，95% CI 0.58 to 0.89），respectively. The AUC of IPF + baseline APACHE II score + NLR，and IPF + baseline APACHE II score + LAR in predicting a high SOFA score was 0.91（95% CI 0.84 to 0.98）and 0.93（95% CI 0.84 to 0.99），respectively. The AUC of IPF + NAR + PLR in predicting the death in sepsis patients was 0.90（95% CI 0.81 to 0.98）. Conclusion IPF combined with different blood indicators can improve the ability to assess the severity and prognosis of sepsis in clinical practice. Specifically，48-hour IPF + baseline APACHE II score+48-hour NLR and 48-hour IPF + baseline APACHE II score+48-hour LAR have high efficacy in predicting the severity of sepsis；whereas 48-hour IPF+NAR+PLR shows a superior efficacy in predicting the prognosis of sepsis.
Subjects: Medicine, Pharmacy >> Clinical Medicine submitted time 2024-07-17 Cooperative journals: 《中国全科医学》
FAN Haojie
LIU Lewei
XIA Lei
TIAN Yinghan
YANG Cheng
HAO Mingru
ZHAO Xin
SHEN Qingqing
MO Daming
GENG Feng
LIU Huanzhong
Abstract： Background The incidence of major depressive disorder（MDD）in adolescents is annually elevated. Non-suicidal self-injury（NSSI）is a common clinical manifestation of MDD. Evidence suggested that vitamin D and lipid levels are associated with MDD，but whether they are related to NSSI is unclear. Objective To compare the levels of 25（OH）D3 and blood lipids in MDD adolescents with or without NSSI behavior， and to explore their diagnostic value for NSSI. Methods A total of 129 MDD adolescents who received treatment in the Department of Psychiatry，Chaohu Hospital of Anhui Medical University and the Fourth People's Hospital of Hefei from October 2020 to March 2022 were recruited. They were assigned into NSSI group （n=77）and non-NSSI group（n=52）based on the diagnostic criteria of NSSI in the Diagnostic and Statistical Manual of Mental Disorders， Fifth Edition （DSM-5）. The Positive and Negative Suicide Ideation Inventory（PANSI），Insomnia Severity Index（ISI），and Center for Epidemiological Survey Depression Scale（CES-D）were used to evaluate the clinical symptoms. Fasting venous blood samples were collected to measure the levels of 25（OH）D3 and blood lipids， and compared between groups. In addition，multivariate logistic regression analysis was performed to identify influencing factors for NSSI behavior in MDD adolescents. The diagnostic value of 25（OH）D3 and lipid levels in NSSI behaviors was assessed by plotting the receiver operating characteristic（ROC） curves. Results The age of the NSSI group was significantly lower than that of the non-NSSI group，whereas the total scores of PANSI，ISI，and CES-D were significantly higher than those of the non-NSSI group（P<0.05）. The level of 25（OH）D3 in the NSSI group was significantly lower than that in the non-NSSI group，whereas the levels of total cholesterol（TC），high-density lipoprotein cholesterol（HDL-C），and low-density lipoprotein cholesterol（LDL-C） were significantly higher than those in the non-NSSI group（P<0.05）. Multivariate Logistic regression analysis showed that both LDL-C（OR=5.695，95%CI=2.422-13.388，P<0.001）and 25（OH）D3（OR=0.871，95%CI=0.768-0.987，P<0.05） were the influencing factors of MDD adolescents with NSSI. The area under curve（AUC）of LDL-C and 25（OH）D3 levels in assessing the risk of developing NSSI behavior in MDD adolescents was 0.73（95%CI=0.65-0.82，P<0.001）and 0.62 （95%CI=0.52-0.72，P=0.023），respectively. Their optimal cut-off value was 1.89 mmol/L and 19.15 μg/L，respectively. The AUC of 25（OH）D3 combined with LDL-C levels ［ln（p/1-p）=1.364X1-0.143X2-0.161，where X1 and X2 was LDL-C and 25（OH）D3，respectively］ in diagnosing NSSI behavior in MDD adolescents was 0.77（95%CI=0.69-0.85， P<0.001），with 77.92% of sensitivity and 67.31% of specificity. Conclusion 25（OH）D3 and lipid levels are out of normal ranges in MDD adolescents with NSSI. Measurement of LDL-C combined with 25（OH）D3 levels may provide information to predict the occurrence of NSSI behaviors in MDD adolescents. A regular measurement of LDL-C and 25（OH）D3 and a dynamic monitor is valuable to provide symptomatic supports.
Subjects: Medicine, Pharmacy >> Clinical Medicine submitted time 2024-07-17 Cooperative journals: 《中国全科医学》
Abstract： Background With the aging population in China，the incidence of vascular cognitive impairment（VCI） will increase year by year. Non-dementia vascular cognitive impairment（VCIND）is the most common form of VCI. At present， the research shows that glycolipid metabolic diseases will accelerate the process of VCI，and the treatment of VCI focuses on controlling risk factors，but there is a lack of relevant research on VCIND caused by glycolipid metabolic diseases. Objective To analyze the factors influencing the occurrence of vascular cognitive impairment no dementia（VCIND）with glycolipid metabolic disease，construct a regression model，and conduct risk prediction. Methods A cross-sectional study was conducted to select410 patients with glycolipid metabolic diseases who were hospitalized in the encephalopathy center of Guangdong Provincial Hospital of Traditional Chinese Medicine from March to December 2023. Patients were divided into a cognitive normal group （MMSE>26 points）and a VCIND group（MMSE ≤ 26 points）according to the Mini-Mental State Examination Scale （MMSE）. Multi-factor Logistic regression was used to evaluate the influencing factors of VCIND in middle-aged and elderly patients with glycolipid metabolic diseases，and the risk prediction model of VCIND in glycolipid metabolic diseases was constructed. The predictive value of the model was evaluated via the receiver's operating characteristic（ROC）curve，and the area under the ROC curve（AUC）was calculated. Results Among the 410 patients，there were 209 cases in the cognitively normal group and 201 cases in VCIND. The results of multivariate Logistic regression analysis showed that low education level ［below primary school（OR=25.989，95%CI=5.656-119.33），primary school（OR=6.839，95%CI=3.919-11.933）， Fazekas grade（OR=1.700，95%CI=1.124-2.570）were independent risk factors for the occurrence of VCIND in patients with glycolipid metabolism（P<0.05）. Based on the results of multivariate Logistic regression analysis，the prediction model is logit （P）=-1.608+ primary school×1.923+ below primary school×3.285+Fazekas grading×0.531. The AUC of this risk prediction regression model is 0.767（95%CI=0.721-0.813，P<0.001）. Hosmer-Lemeshow goodness-of-fit test showed that the model has a good fitting effect（χ2 =13.404，P=0.099）. Conclusion Low literacy and Fazekas classification are independent risk factors for the development of VCIND in a population of patients with glycolipid metabolism. Establishing a risk prediction regression model based on the above risk factors has a good predictive value and helps to identify the high-risk group of developing VCIND in patients with glycolipid metabolism disease at an early stage.
Subjects: Medicine, Pharmacy >> Clinical Medicine submitted time 2024-07-17 Cooperative journals: 《中国全科医学》
Abstract： Background Insomnia not only decreases the quality of life and working efficiency，but also relates to other deceases. Suitable exercises may be useful to improve sleep quality. However，comparative studies on the effects of different types of exercise on sleep outcomes are currently lacked. Objective To compare the effects of different exercise types on sleep in insomnia patients and to provide insights for developing exercise prescriptions to improve sleep in this population. Methods Randomized controlled trials（RCTs） investigating the effects of different types of exercises on the sleep of people with insomnia were retrieved from the PubMed，Web of Science，EBSCO，Scopus，China National Knowledge Infrastructure（CNKI），and Wanfang Data Knowledge Service Platform from database inception to December 2023. The quality of the literatures was assessed using the Jadad scale. A network meta-analysis was performed using the random-effects model of the frequency framework in Stata 17.0 software，and publication bias was observed using a funnel plot. Results A total of 36 articles representing 2706 participants were included in this study. Exercise interventions were categorized into five types，including the aerobic exercise（AE）， resistance training（RT），mind-body exercise（ME），prolonged time of exercise（PTE），and AE combined with RT（AE+RT）. The results of the network meta-analysis showed that there was a significant difference in the total score of the subjective evaluation tools between AE group and blank control group（SMD=2.20，95%CI=0.35-4.05，P<0.05）. The maximum surface under the cumulative ranking curve（SUCRA） of the total score of the subjective evaluation tools was detected in AE group（82.2%）， followed by ME（71.1%），AE+RT（54.2%），RT（38.9%），controlled trial（CT）（29.2%） and PTE groups（24.4%）. There was a significant difference in sleep latency（SL） between PTE group versus AE+RT group（SMD=-14.66，95%CI=- 28.60--0.72），between AE+RT group versus RT group（SMD=21.32，95% CI 6.24-36.4），and between AE+RT group versus AE group（SMD=11.19，95%CI=1.56-20.81）（all P<0.05）. The maximum SUCRA of SL was detected in AE+RT group（96.7%），followed by CT（77.1%），ME（49.5%），AE（42.6%），PTE（27.9%）and RT groups（6.1%）. There was a significant difference in sleep efficacy（SE）between AE group versus CT group（SMD=4.59，95%CI=1.59-7.58， P<0.05）. The maximum SUCRA of SE was detected in the AE group（83.1%），followed by AE+RT（59.9%），RT（50.7%）， ME（46.9%），PTE（35.5%）and CT groups（23.9%）. There was a significant difference in wake time after sleep onset（WASO） between PTE group versus RT group（SMD=23.39，95%CI=14.67-32.02），between PTE group versus AE group（SMD=14.86， 95%CI=4.64-36.40），between PTE group versus CT group（SMD=12.11，95%CI=7.62-16.59），between RT group versus ME group（SMD=-27.61，95%CI=-40.49--14.73），between RT group versus CT group（SMD=-11.28，95%CI=-20.86- -1.70），between ME group versus AE group（SMD=19.08，95%CI=5.18-32.98），and between ME group versus CT group （SMD=16.33，95%CI=7.26-25.40）（all P<0.05）. The maximum SUCRA of WASO was detected in the RT group（94.7%）， followed by CT（80.2%），AE（41.8%），ME（31.5%） and PTE groups（1.7%）. There was a significant difference in the total sleep time（TST）between RT group versus AE group（SMD=-20.84，95%CI=-38.46--3.23），between AE group versus CT group（SMD=12.02，95%CI=2.96-21.08）（all P<0.05）. The maximum SUCRA of TST was detected in the AE group（87.2%），followed by AE+CT（71.6%），PTE（53.8%），ME（40.6%），CT（35.9%）and RT groups（10.8%）. There was no significant difference in the sleep quality（SQ）among groups（P>0.05）. The maximum SUCRA of SQ was detected in the AE group（84.2%），followed by AE+CT（75.5%），ME（24.9%）and CT groups（15.4%）. Publication bias analysis of the total score of subjective evaluation tools，SL，SE，WASO，TST，and SQ revealed some asymmetry in all six outcome indicators，indicating a certain risk of publication bias. Conclusion Given the favorable effects of AE on multiple sleep parameters，we recommend insomnia patients engage in moderate-intensity AE，such as jogging or brisk walking，three times a week for approximately 30 minutes. Additionally，options include moderate-intensity RT or AE+RT four to five times a week. When engaging in the above exercises，attention should be paid to the choice of time period，and exercise within 3 hours before bedtime should be avoided as much as possible.
Subjects: Medicine, Pharmacy >> Clinical Medicine submitted time 2024-07-17 Cooperative journals: 《中国全科医学》
Abstract： Background Mycoplasma pneumoniae pneumonia（MPP） is a common respiratory disease in children，which can easily develop into refractory Mycoplasma pneumoniae pneumonia（RMPP）. Children with RMPP have complex conditions，are difficult to treat，and are associated with multiple serious complications. A risk prediction model for RMPP in children can help healthcare professionals to identify children at high risk of RMPP and provide timely therapeutic countermeasures. Objective To systematically review the risk prediction models for RMPP in children. Methods CNKI， Wanfang Data，VIP，CBM，PubMed，Embase，Web of Science and Cochrane Library were searched to collect the related studies on risk prediction models for RMPP in Children to February 20th，2024. Two reviewers independently screened the literature，extracted data and evaluated the quality of the included studies. Meta-analysis of the incidence and predictors of RMPP in children was performed using Stata 18.0 software. Results A total of 14 papers were included，containing 17 risk prediction models. Ten studies were internal validated，and only four studies were external validated，all of which had AUC>0.7. PROBAST results showed that 14 included papers were all at high risk of bias. The results of Meta-analysis showed that the incidence of RMPP in children was 28.2%（95%CI=21.2%~35.1%），hyperthermia，lactate dehydrogenase，c-reactive protein，age， neutrophil ratio，procalcitonin and D-Dimer were independent influences on the occurrence of RMPP in children（P<0.05）. Conclusion Risk prediction models for RMPP in children have good predictive performance，but the overall risk of bias was high and external validation was lacking. The future risk prediction model should focus on hyperthermia，lactate dehydrogenase， c-reactive protein，age，neutrophil ratio，procalcitonin and D-Dimer.
Subjects: Biology >> Botany >> Applied botany submitted time 2024-07-17 Cooperative journals: 《广西植物》
Abstract： In order to explore the anti-colorectal cancer activity of Bothriospermum zeylanicum, the compounds were isolated from the ethyl acetate fraction by ODS gel column chromatography, high-pressure preparative liquid chromatography and other methods. MS, NMR and other spectroscopic were used to identify the structure of the compounds. And then the effects of the compounds on the proliferation of human colorectal cancer cells ( SW620, HT-29 ) and human normal colon epithelial cells ( NCM460 ) were detected by CCK8 method. The results were follows: (1) A total of 12 compounds were identified from the ethyl acetate fraction of B. zeylanicum, including fumaric acid (1), protocatechuic acid (2), monomethyl fumarate (3), 3,4, α-trihydroxymethylphenyl propionate (4), p-hydroxybenzoic acid (5), echiumin A (6), echiumin B (7), (+)-isolariciresinol-2a-O-β-D-glucopyranoside(8), p-coumaroyl-α-L- rhamnopyranoside (9), p-coumaric acid (10), (-)-5-methoxyisolariciresinol-3α-O-β-D-glucopyranoside (11), rupestrin B (12). Compounds 1-12 were isolated from B. zeylanicum for the first time. (2) Compounds 8 and 12 showed a certain inhibitory effect on the proliferation of SW620 cells, with IC50 values of （9.34±1.10）μmol·L-1 and（0.33±0.06）μmol·L-1, respectively. Compound 12 showed a certain inhibitory effect on the proliferation of HT-29 cells, with IC50 value of （15.94±1.56） μmol·L-1. This finding enriched the chemical composition of B. zeylanicum, and it was further clarified its anti-colorectal cancer activity ingredients. which provided a reference for the development and utilization of B. zeylanicum.
Subjects: Biology >> Botany >> Applied botany submitted time 2024-07-17 Cooperative journals: 《广西植物》
Abstract： Qinghai Provinc e, as a core component of the Qinghai Tibet Plateau, shares similar geological and geomorphological formations as well as an evolutionary history of its natural ecosystem with the entire Qinghai Tibet Plateau. Within Qinghai, there exist 97 families, 595 g enera, and 3 558 species of wild seed plants. Based on the author’s extensive field research and data accumulation, this article presents a classification and analysis of the distribution area types of all plant families, genera, and species in Qinghai. Th e key findings are as follows : (1) Qinghai hosts all 15 areal types described in Mr. Wu Zhengyi’s "Distribution Area Types of Chinese Seed Plant Genera," indicating the richness of its floral components and the complexity and diversity of its ecological an d geographical environment. (2) Tropical types, primarily represented by pan tropical distributions, are characterized by marginal distribution within Qinghai, with the absence of woody types. (3) At the genus level, the core components of Qinghai’s flora are predominantly warm cold genera originating from the Northern temperate zone and East Asia. However, at the species level, species distributed in Temperate Asia and East Asia dominate. (4) The unique Chinese type of flora in Qinghai reflects its close a ffinity with the flora of Southwest China (Hengduan Mountains) and the Himalayas, and exhibits distinct alpine flora characteristics of the Qinghai Xizang Plateau. (5) The southwest and northern flora of China has great influence on Qinghai. (6) Qinghai ha s three distinct ecological zones in Qinghai: the warm and humid Qilian Mountains, the alpine southern Qinghai Plateau, and the temperate and arid Qaidam Basin, and each zone exhibits distinct and prominent characteristics. Intersection of the three zones reveals the transitional nature of the flora. (7) The terminal or marginal distribution areas of many plant species in Qinghai are particularly evident, marked by the westernmost extent of their distribution ranges and the highest altitudinal limits. (8) Q inghai’s flora exhibits a youthful and derived taxonomic nature, primarily consisting of perennial herbaceous species and a paucity of woody types. This analysis concludes that Qinghai’s flora is dominated by northern temperate components, particularly tho se endemic to the temperate and cold zones of Eurasia. Qinghai possesses the temperate flora attributes of warmth, cold, and alpine types, reflecting the complexity of its flora. For the first time in China, a "species level" distribution area type system for wild seed plants in Qinghai has been established.
Subjects: Biology >> Botany >> Applied botany submitted time 2024-07-17 Cooperative journals: 《广西植物》
Abstract： To study the chemical constituents from Argyreia pierreana and their cytotoxic activity, the compounds were isolated and purified using methods including silica gel, Sephadex LH-20, C18 medium and low pressure column chromatography and semi-preparative HPLC. The structures of the compounds were identified through a combination method of physicochemical properties, spectral techniques and compared with literature references. The isolated compounds were tested for their proliferation inhibition effects on tumour cells using MTS assay. The results were as follows: (1) Twelve compounds were isolated from the A. pierreana and identified as argypierin A (1), 4’-hydroxy-5,7-dimethoxy-6-(3-methyl- 2-butenyl)-isoflavone (2), 2-hydroxy-3-methyl anthraquinone (3), rubiadin (4), rubiadin-1-methyl ether (5), grossamide (6), methyl 1,4-di-O-caffeoylquinate (7), 3,4-di-O-caffeoyl quinic acid methyl ester (8), 3,5-di- O-caffeoyl quinic acid methyl ester (9), 3,5-di-O-caffeoyl quinic ethyl ester (10), ω- hydroxypropioguaiacone (11), C-veratrylglycol (12). Among them, Compound 1 was a new compound. Compounds 2-7, 10-12 were isolated from A. pierreana for the first time. Compounds 2-7, 11, 12 were isolated from the genus of Argyreia Lour. for the first time. (2) Compound 6 had good cytotoxic activity against human tumor cell line HL-60, breast cancer MDA-MB-231 and colon cancer SW480 cells with IC50 values of (10.89 ± 0.37), (16.37 ± 1.13), (17.35 ± 0.44), respectively.
Subjects: Biology >> Botany >> Applied botany submitted time 2024-07-17 Cooperative journals: 《广西植物》
Abstract： Determining an appropriate scale is crucial in landscape pattern analysis and ecological research. In order to gai n deeper insights into the spatial diversity and dynamic characteristics of landscape patterns, based on the survey data from the 12 hm 2 plot in Guanshan National Nature Reserve, Jiangxi Province, during 2015 to 2020, we analyzed the scale effect of eight different landscape types landscape indices within the range of 5 50 meters. The variation coefficients were used to reveal the changing characteristics of different landscape pattern indices as the scale increases, and the optimal scale was selected based on the inflection points of changes in various landscape indices. The results were as follows: (1) Based on the importance value analysis, eight different landscape types were identified in the arbor layer of the plot, including gap (GAP), bamboo forest ( BBF), Cunninghamia lanceolata forest (CLF) CLF), P massoniana forest (PMF) b road leaved f orest (BLF), b amboo and C. lanceolata mixed forest (BCF), b amboo and P massoniana mixed forest (BPF), C. lanceolata and P. massoniana mixed forest (CPF) CPF). (2) The overall distribution of patches in the landscape is relatively balanced, and the distribution pattern remains relatively stable. At larger spatial granularity, the aggregation of each landscape type increases, leading to a higher probability of landscape merging. In contrast, at smaller granularity, there is a noticeable trend of fragmentation in landscape types, providing a more comprehensive display of the quantity, density, and shape of each landscape type. Number of p atches (NP) effectively characterizes the d egree of landscape fragmentation, m ean s hape i ndex SHAPE_MN ) accurately reflects patch shape, and Shannon’s d iversity i ndex ( SHDI ) better explains the diversity of landscape types. Patch d ensity (PD) PD), NP , e dge d ensity ED )), l andscape s hape i ndex LSI )), f r actal d imension i ndex FRAC_MN )), c ontagion i ndex CONTAG exhibits significant negative correlations with increasing granularity, while m ean p atch a rea AREA_MN )), SHDI, Shannon’s e venness i ndex SHEI exhibits significant positive correlations with increas ing granularity. (3) T he coefficients of variation for landscape indices PD, NP, ED, LSI, and AREA_MN are the highest, combining landscape structural stability and diversity, the changes in different landscape indices are primarily concentrated around the inflection point at 5 meters. These results illustrate the diversity of landscape types, with the coefficient of variation reflecting the most sensitive characteristics of landscape pattern changes. This study suggests that a granularity of 5 meters is opt imal for studying the landscape pattern of subtropical evergreen broad leaved forests in Guanshan, Jiangxi.
Subjects: Biology >> Botany >> Applied botany submitted time 2024-07-17 Cooperative journals: 《广西植物》
Abstract： Elymus nutans, a high-quality forage distributed on the Qinghai-Tibetan Plateau, holds significant ecological and economic value. The TCP transcription factors, a plant-specific family, play a crucial regulatory role in plant growth and development processes, including leaf development, branch morphogenesis, and phytohormone signaling pathways. In this study, Single molecule real-time (SMRT) sequencing technology was used to obtain full-length transcript data from E. nutans, which to adied in the identification of TCP transcription factors. Meanwhile, we employed the Illumina sequencing platform to investigate the response patterns of E. nutans under four different phytohormones treatments. The results were as follows: (1) A total of 90 956 non-redundant full-length non-chimeric (FLNC) sequences were obtained. (2) A total of 26 EnTCPs were identified based on the full-length transcriptome data. Bioinformatics analysis revealed a diverse range of amino acids in these EnTCPs (186 to 575 aa), with all EnTCPs predicted to be located in the nucleus. (3) Based on the branching of the phylogenetic tree, the 26 EnTCPs were divided into Class I subfamily, Class II-a (CIN) subfamily, and Class II-b (CYC/TB1) subfamily. Conserved motifs analysis revealed that all EnTCPs possess a TCP domain. (4) Expression pattern analysis suggested that the expression of 7 EnTCPs family members (En108950, En35573, En10347, En16325, En128790, En10346, and En14028) was up-regulated/down-regulated under different phytohormones treatment, suggesting their potential involvement in hormone synthesis pathways. QRT-PCR analysis results showed that En35573 and En14028 are involved in auxin response, while En108950, En10347, En128790, En10346, and En14028 are all involved in cytokinin response. En14028 is involved in abscisic acid response, En108950 is involved in jasmonic acid response, and En16325 may be involved in multiple hormone signaling pathways. These findings provide a foundation for further exploration of the function of the EnTCPs gene and can serve as a reference.
Subjects: Biology >> Botany >> Applied botany submitted time 2024-07-17 Cooperative journals: 《广西植物》
Abstract： SPINDLY (SPY) is a novel nucleocytoplasmic protein O-fucosyltransferase that regulates target protein activity or stability via O-fucosylation. Previous studies have indicated that the SPY protein regulates plant growth and development by modulating various intracellular processes in Arabidopsis thaliana. Its mediated O-fucosylation plays an important role in maintaining cell homeostasis and regulating plant growth and development, however protein O-fucosylation regulated by SPY in other plants largely remain unknown. Maize (Zea mays ) is one of the most important cereals crops for supplying foods, fibers, and fuels to humans. In order to explore the function of maize fucosyltransferase gene (ZmSPY), this study first analyzed the conserved domain, amino acid sequence and physicochemical properties of ZmSPY protein by bioinformatics means, and cloned the gene from maize root tissue to construct the GFP fusion protein expression vector. The subcellular localization of ZmSPY was analyzed, and its response to different hormone treatments (GA, IAA, 6BA, ABA) was determined by exogenous hormone application. And the results were as follows: (1) ZmSPY proteins belong to the TPR and SPY superfamilies, and structural analysis demonstrated that ZmSPY had TPR (Tetratricopeptide repeat) and catalytic domains. (2) Phylogenetic analysis shows that SPYs are highly conserved, and ZmSPY exhibits strong homology to SPY in Sorghum bicolor. (3) Sequence analysis shows that the CDS region of ZmSPY is 2736 bp. Physicochemical analysis indicates that ZmSPY, which contains 911 amino acids and 33 glycosylation sites, is hydrophilic and non-secretory. Its secondary and tertiary structure is largely composed of alpha helix and random coil. (4) The subcellular localization of ZmSPY is predominantly observed in the nucleus. (5) The expression of ZmSPY is induced by phytohormones including GA, IAA, 6BA and ABA, and exhibits various expression patterns. This study provides foundational information on SPY in maize, which could contribute to further investigation of SPY and its effect on O-fucosylation in cereal plants.
Subjects: Biology >> Botany >> Applied botany submitted time 2024-07-17 Cooperative journals: 《广西植物》
Abstract： To investigate the germination physiological mechanism of Paris polyphylla var. chinensis seeds, different stages of the germination process were divided based on the seed embryo morphology and the changes in endogenous hormone content and related enzyme activities were analyzed at different stages. The results were as follows: (1) Th e germination process of the seeds can be divided into eight stages based on seed embryo morphology: non germinating embryo stage (S1), heart shaped embryo stage (S2), embryo swelling stage (S3), radicler not breaking through seed coat stage (S4), cotyledo n petiole elongation and radicle breaking through seed coat stage (S5), lower hypocotyl breaking through seed coat stage (S6), upper hypocotyl elongation stage (S7), and radicle elongation stage (S8). (2) The α amylase activity in the seeds was significant ly higher than β amylase activity in all germination stages. (3) Superoxide dismutase (SOD) activity was highest in stage S5 and lowest in stage S1; peroxidase (POD) and catalase (CAT) activities generally increased with germination progress; soluble prote in content initially decreased and then increased with germination progress. (4) The content of hormones such as indole 3 acetic acid (IAA), gibberellin (GA 3 ), abscisic acid (ABA), and salicylic acid (SA) decreased overall, while 1 aminocyclopropane 1 carb oxylic acid (ACC), jasmonic acid (JA), brassinosteroids (BRs) increased overall during seed germination. Cytokinins (CTKs) content showed no significant change. The ratios of IAA/ABA and GA 3 /ABA decreased initially and then increased, while CTKs/ABA contin uously increased with seed germination progress. (5) The contents of ABA, IAA, GA 3 were negatively correlated with embryo rate, while ACC, JA, BRs, POD, CAT, and β amylase activity were positively correlated with embryo rate. In conclusion, the germination process of the seeds can be subdivided into eight stages based on seed embryo morphology, with varying endogenous hormone content and related enzyme activities at different stages. The activities of α amylase and POD may be related to radicle elongation, while GA 3 may affect the embryo formation, and ABA may inhibit the growth and development of the embryo.
Subjects: Biology >> Botany >> Applied botany submitted time 2024-07-17 Cooperative journals: 《广西植物》
Abstract： Estimating gross primary productivity (GPP) of vegetation is essential for exploring the flow and storage of carbon in terrestrial ecosystems and helps to explain the factors influencing global climate change. Remote sensing GPP models are important tools for simulating GPP at regional and global scales. In order to clarify the applicability of two remote sensing GPP models, TG and VI, to two typical forests in the meso-subtropical region as well as the simulation effects of different model parameter calibration methods, the present study was conducted to calibrate the sensitive parameters of the TG and VI models based on the ground-based meteorological data and MODIS data using flux-tower measured GPP at both year-round and seasonal scales, and then the GPPs of the meso-subtropical regenerated broad-leaved evergreen forest and the eucalyptus The GPP of meso-subtropical secondary evergreen broadleaf forest and eucalyptus plantation forest were simulated, and the simulation accuracies of the TG and VI models in these two ecosystems were compared and analyzed. The results were as follows: (1) The simulation accuracy of the models was improved after parameter calibration, especially in the case of seasonal calibration, the simulation accuracy was significantly better than that of the year-round calibration. (2) The correlation between the input parameters of the TG and VI models and the measured GPP of the two ecosystems was high (R2 >0.70 ， P<0.001). (3) The correlation between the simulated and measured GPPs of the TG model was higher than that of the VI model, and the simulation error of the TG model was the smallest in the secondary broadleaf evergreen forest ecosystem (RE< 2%). In conclusion, both models have the potential to be applied in two typical forests in the central subtropical region, and the simulation effect of the TG model is better than that of the VI model.
Subjects: Biology >> Botany >> Applied botany submitted time 2024-07-17 Cooperative journals: 《广西植物》
Abstract： Aleuritopteris argentea (S. G. Gmelin) Fée, A. subargentea Ching, and A. michelii (Christ) Ching belong to the genus Aleuritop teris of Pteridaceae subfam. Cheilanthoideae. Their phylogenetic relationship has long been in controversy due to morphological similarities, resulting in different classification treatment. In this paper, the phylogenetic relationships between the three s pecies based on molecular and morphological analyses were investigated. The results we re as follows: (1) B ased on the chloroplast genome and the ribosomal DNA , A. argentea and A. subargentea are two distinct species ; s amples of A. michelii were not cluste red into a monophyletic lineage, and individuals were embedded in a monophyletic lineage formed by samples of A. subargentea . (2) Statistical analysis of the morphological data showed that A. argentea and A. subargentea differed significantly in morphologi cal traits A. michelii and A. subargentea did not differ significantly in morphological traits. In summary b ased on the above results, this study suggested that A. subargentea should be recognized as a distinct species and A. michelii should be treated a s a synonymy of A. subargentea
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