分类： 心理学 >> 实验心理学 提交时间： 2017-10-13
Ning Yang
Ye He
Zhe Zhang
Hao-Ming Dong
Lei Zhang
Xing-Ting Zhu
Xiao-Hui Hou
Yin-Shan Wang
Quan Zhou
Zhu-QingGong
Li-Zhi Cao
Ping Wang
Yi-Wen Zhang
Dan-Yang Sui
TingXu1
Gao-Xia Wei
Zhi Yang
Lili Jiang
Hui-Jie Li
Ting-YongFeng
摘要： Abstract: To face the challenges of keeping healthy in increasing population sizes of both ageing and developing people in China, a fundamental request from the public health is the development of lifespan normative trajectories of brain and behavior. This paper introduces the Chinese Color Nest Project (CCNP 2013–2022), a large-scale tenyear program of modeling brain and behavioral trajectories for human lifespan (6–85 years old). We plan to gradually collect the behavioral and brain imaging data at ages across the lifespan on nationwide and depict the normal trajectory of Chinese brain development across the lifespan, based on the accelerated longitudinal design in the coming next 10 years starting at 2013. Various psychiatric disorders have been demonstrated highly relevant to abnormal events during the neurodevelopment regarding their onset ages of first episodes. Therefore, delineation of normative growth curves of brain and cognition in typically developing children is extremely useful for monitoring, early detecting and intervention of various neurodevelopmental disorders. In this paper, we detailed the developing part of CCNP, devCCNP. It tracked 192 healthy children and adolescents (6–18 years old) in Beibei district of Chongqing for the first 5 years of the full CCNP cohort (2013–2017). To demonstrate the feasibility of implementing the longterm follow-up of CCNP, we here comprehensively document devCCNP in terms of its experimental design, sample strategies, data acquisition and storage as well as some preliminary results and data sharing roadmap for future. Specifically, we first describe the accelerated longitudinal sampling design as well as its exact ratio of sample dropping off during the data collection. Second, we present several initial findings such as canonical growth curves of cortical surface areas of a set of well-established large-scale functional networks of the human brain. Finally, together with records generated by many psychological and behavioral tests, we will provide an individual growing-up report for each family participating the program, initiating the potential guidance on the individual academic and social development. The resources introduced in the current work can provide first-hand data for a series of coming Chinese brain development studies, such as Chinese Standard MRI Brain Templates, Normative Growth Curves of Chinese Brain and Cognition as well as Mapping of Language Areas in Chinese Developing Brain. These would not only offer normative references of the atypical brain and cognition development for Chinese population but also serve as a strong force on accelerating the pace of integrating Chinese brain development into the national brain program or Chinese Brain Project.
分类： 数学 >> 建模与仿真 提交时间： 2017-05-25
摘要： Millions of people benefit form Traditional Chinese Medicine TCM every day. Unfortunately till now TCM has not been accepted as science by world especially western people. Bian Zheng Lun Zhi is distillation of TCM. Syndrome is key in system of Bian Zheng Lun Zhi. Study about the syndrome is core of study of basic theory of TCM. We creatively interpret TCM through a view of cognitive science and take syndromes of TCM as concepts of brain. This paper try to introduce syndrome to western people in order to let western people understand our viewpoints more easily the best method is to adopt a manner that is easily understood by them already exists and has been thought to be right. So we employ neural network presented by foreign people as brain model instead of network presented by us Using two classic case of TCM we successfully clarify the three main properties of syndrome in TCM.
分类： 心理学 >> 发展心理学 提交时间： 2020-10-10
摘要： Building robust letter-to-sound correspondences is a prerequisite for reading, and such audiovisual integration becomes progressively automatic with development. However, the neural mechanisms underlying the development of audiovisual integration for reading are largely unknown. This study used functional magnetic resonance imaging (fMRI) in a lexical decision task to investigate the changes of brain functional networks that support audiovisual integration for reading between normally developing children (9-12 years old) and adults (20-28 years old). The identified networks were further examined in children with developmental dyslexia (9-12 years old). Results revealed that adults enhanced connectivity in a prefrontal-superior temporal network relative to children, reflecting the attentional modulation to the development of audiovisual integration. Moreover, this network was disrupted in dyslexics, confirming its essential role in audiovisual integration for reading. This study, for the first time, elucidates the neural basis underlying the development of audiovisual integration for reading.
分类： 心理学 >> 认知心理学 提交时间： 2020-06-30
摘要： Metacognition refers to the ability to introspect our cognitive ability, which plays an essential role in guiding and optimizing our activities. However, little is known about metacognitive capacity for highly practiced motor behaviors and its neural correlates. Using structural and functional magnetic resonance imaging (MRI), the present study examined the brain substrates underlying individual differences in self-awareness of handwriting in adults, a highly practiced visuomotor skill. Results showed that adult writers generally overestimate their handwriting skill, which is more pronounced in males relative to females. The extent of overestimation of handwriting quality was positively correlated with grey matter volume in the left fusiform gyrus, right middle frontal gyrus and right precuneus. Moreover, the activation of these regions in a handwriting task was not correlation with self-awareness of handwriting, confirming that the identified connection between brain structures and handwriting self-awareness is independent of task performances. The left fusiform gyrus and right middle frontal gyrus are thought to represent domain-specific brain mechanisms for handwriting self-awareness, while the right precuneus is likely to be a domain-general brain mechanism, suggesting that the ability of introspect practiced visuomotor skills relies on both domain-general and domain-specific brain systems. Together, this study is the first to reveal the neuroanatomical correlates of a highly practiced motor behavior, extending our understanding about the neural basis of human metacognition.
分类： 生物学 >> 生物物理学 提交时间： 2016-05-12
Yan, Xinqiang
Yan, Xinqiang
Yan, Xinqiang
Xie, Zhentian
Zhang, Xiaoliang
Pedersen, Jan Ole
Zhang, Xiaoliang
摘要： Radiative antenna techniques, e.g., dipole and monopole, have been proposed for radiofrequency (RF) coil array designs in ultrahigh field MRI to obtain stronger B-1 field and higher signal-to-noise ratio (SNR) gain in the areas deep inside human head or body. It is known that element decoupling performance is crucial to SNR and parallel imaging ability of array coil and has been a challenging issue in radiative antenna array designs for MR imaging. Magnetic wall or induced current elimination (ICE) technique has proven to be a simple and effective way of achieving sufficient decoupling for radiative array coils experimentally. In this study, this decoupling technique for radiative coil array was analyzed theoretically and verified by a simulation study. The decoupling conditions were derived and obtained from the theory. By applying the predicated decoupling conditions, the isolation of two radiative elements could be improved from about -8 dB to better than -35 dB. The decoupling performance has also been validated by current distribution along the radiative elements and magnetic field profiles in a water phantom. (c) 2015 Wiley Periodicals, Inc.
分类： 心理学 >> 心理统计 提交时间： 2018-12-07
摘要： Human brain mapping (HBM) is increasingly becoming a multi-disciplinary field where some scientific issues are fundamental for all scientists and applications of using the technology to investigate individual differences. Reliability represents a significant issue for all scientific fields and has particularly been overlooked for decades by the HBM field [1]. Meanwhile, recent advances in open science have offered the field big data for developing novel methodological frameworks as well as performing large-scale investigations of the brain-mind associations based upon the individual differences assessed with HBM [2]. A systematic investigation of reliability seems still far behind these HBM developments. It is critical that reliability is evaluated ahead of these applications, motivating the current commentary on delineation of the anatomy of reliability for future HBM.
分类： 计算机科学 >> 计算机应用技术 提交时间： 2017-05-20
摘要： Decoding human brain activities via functional magnetic resonance imaging (fMRI) has gained increasing attention in recent years. While encouraging results have been reported in brain states classification tasks, reconstructing the details of human visual experience still remains difficult. Two main challenges that hinder the development of effective models are the perplexing fMRI measurement noise and the high dimensionality of limited data instances. Existing methods generally suffer from one or both of these issues and yield dissatisfactory results. In this paper, we tackle this problem by casting the reconstruction of visual stimulus as the Bayesian inference of missing view in a multiview latent variable model. Sharing a common latent representation, our joint generative model of external stimulus and brain response is not only ``deep" in extracting nonlinear features from visual images, but also powerful in capturing correlations among voxel activities of fMRI recordings. The nonlinearity and deep structure endow our model with strong representation ability, while the correlations of voxel activities are critical for suppressing noise and improving prediction. We devise an efficient variational Bayesian method to infer the latent variables and the model parameters. To further improve the reconstruction accuracy, the latent representations of testing instances are enforced to be close to that of their neighbours from the training set via posterior regularization. Experiments on three fMRI recording datasets demonstrate that our approach can more accurately reconstruct visual stimuli.
分类： 生物学 >> 生物物理学 提交时间： 2016-05-12
Zhang, Zihao
Zuo, Zhentao
Wang, Bo
Wei, Ning
Xue, Rong
Zhang, Zihao
Wei, Ning
Deng, Xiaofeng
Zhao, Jizong
Weng, Dehe
An, Jing
Xue, Rong
摘要： Purpose: Time-of-flight (TOF) MR angiography has an advantage of contrast and resolution in ultra-high field (7 T) MRI systems. However, increased specific absorption rate (SAR) prohibits the application of spatial saturation band, leading to venous contamination in maximum intensity projection (MIP) images. Methods: A segmented k-space filling scheme with sparse venous saturation pulses was developed for 7 T TOF-MRA. The effectiveness of the segmented TOF sequence was verified by Bloch equation simulation and experiments on 3 T. The protocol on 7 T was optimized and applied for healthy volunteers and patients with vascular diseases. Results: Segmented TOF achieved equivalent contrast and venous suppression effect as conventional methods, while SAR values had a remarkable reduction and obeyed the limit of a 7 T MRI system. The decreased number of saturation pulses allowed shorter acquisition time than existing solutions. The comparison of segmented TOF and conventional TOF revealed flow direction in vascular diseases. Conclusion: Segmented TOF is proved to be a time-efficient way to achieve high-resolution angiograms without venous contamination at ultra-high field. The sequence holds strong promise for non-contrast clinical diagnosis on cerebrovascular diseases. (C) 2015 Elsevier Inc. All rights reserved.
分类： 生物学 >> 生物物理学 提交时间： 2016-05-12
Yan, Xinqiang
Wei, Long
Yan, Xinqiang
Wei, Long
Yan, Xinqiang
Xue, Rong
Xue, Rong
Zhang, Xiaoliang
Zhang, Xiaoliang
摘要： The monopole coil and loop coil have orthogonal radiofrequency (RF) fields and thus are intrinsically decoupled electromagnetically if they are laid out appropriately. In this study, we proposed a hybrid monopole/loop technique which could combine the advantages of both loop arrays and monopole arrays. To investigate this technique, a hybrid RF coil array containing four monopole channels and four loop channels was developed for human head magnetic resonance (MR) imaging at 7 T. In vivo MR imaging and g-factor results using monopole-only channels, loop-only channels and all channels of the hybrid array were acquired and evaluated. Compared with the monopole-only and loop-only channels, the proposed hybrid array has the higher signal-to-noise ratio (SNR) and better parallel imaging performance. Sufficient electromagnetic decoupling and diverse RF magnetic field (B-1) distributions of monopole channels and loop channels may contribute to this performance improvement. From experimental results, the hybrid monopole/loop array has low g-factor and excellent SNR at both periphery and center of the brain, which is valuable for human head imaging at ultrahigh fields.
分类： 计算机科学 >> 计算机科学的集成理论 提交时间： 2022-11-28 合作期刊: 《数据智能（英文）》
摘要： A recurring pattern of access to existing databases, data analyses, formulation of new hypotheses, use of an experimental design, institutional review board approvals, data collection, curation, and storage within trusted digital repositories is observable during clinical research work. The workflows that support the repeated nature of these activities can be ascribed as a Canonical Workflow Framework for Research (CWFR). Disease area clinical research is protocol specific, and during data collection, the electronic case report forms can use Common Data Elements (CDEs) that have precisely defined questions and are associated with the specified value(s) as responses. The CDE-based CWFR is integrated with a biomedical research informatics computing system, which consists of a complete stack of technical layers including the Protocol and Form Research Management System. The unique data dictionaries associated with the CWFR for Traumatic Brain Injury and Parkinsons Disease resulted in the development of the Federal Interagency Traumatic Brain Injury and Parkinsons Disease Biomarker systems. Due to a canonical workflow, these two systems can use similar tools, applications, and service modules to create findable, accessible, interoperable, and reusable Digital Objects. The Digital Objects for Traumatic Brain Injury and Parkinsons disease contain all relevant information needed from the time data is collected, validated, and maintained within a Storage Repository for future access. All Traumatic Brain Injury and Parkinsons Disease studies can be shared as Research Objects that can be produced by aggregating related resources as information packages and is findable on the Internet by using unique identifiers. Overall, the integration of CWFR with an informatics system has resulted in the reuse of software applications for several National Institutes of Health-supported biomedical research programs.
分类： 心理学 >> 实验心理学 提交时间： 2017-11-06
摘要： Various resting-state fMRI (R-fMRI) measures have been developed to characterize intrinsic brain activity. While each of these measures has gained a growing presence in the literature, questions remain regarding the common and unique aspects these indices capture. The present work provided a comprehensive examination of inter-individual variation and intra-individual temporal variation for commonly used measures, including fractional amplitude of low frequency fluctuations, regional homogeneity, voxel-mirrored homotopic connectivity, network centrality and global signal correlation. Regardless of whether examining intra-individual or inter-individual variation, we found that these definitionally distinct R-fMRI indices tend to exhibit a relatively high degree of covariation. When taken as a measure of intrinsic brain function, inter-individual differences in concordance for R-fMRI indices appeared to be stable, and negatively related to age (i.e., functional concordance among indices decreases with age). To understand the functional significance of concordance, we noted that higher concordance was generally associated with higher strengths of R-fMRI indices, regardless of whether looking through the lens of inter-individual (i.e., high vs. low concordance participants) or intra-individual (i.e., high vs. low concordance states identified via temporal dynamic analyses) differences. Finally, temporal dynamics analyses also revealed that high concordance states are characterized by increased within- and between-network functional connectivity, suggesting more general variations in network integration and segregation. The current study draws attention to questions regarding how to select an R-fMRI index for usage in a given study, as well as how to compare findings across studies that examine inter-individual or group differences using different indices. Additionally, our work suggests global neural signals exist in the brain, and their spontaneous variations over time result in fluctuations in the connectedness of brain regions.
分类： 物理学 >> 普通物理:统计和量子力学,量子信息等 分类： 计算机科学 >> 计算机科学的集成理论 提交时间： 2017-03-15
摘要： As the next stage of Artificial Intelligence, Brain-like Intelligent Computing will be considered as a fundamental role in the forthcoming China Brain Project. Researchers have tried to use the brain frame structure and the brain functions, aiming at developing a new generation of information theory and computational methods (such as a new generation of artificial intelligence systems). Different from the traditional information processing based on the classical physics and logics, the human brain should rely on a deeper level physics (such as quantum mechanics) to process information, generate awareness and consciousness. The project will try to exploit quantum information theory in the human cognition related information interaction and processing models. The overall research goal is: in typical information interaction scenarios (such as exploratory information access and natural language understanding), modeling the non-classical (quantum or quantum-like) experimental phenomenon, developing quantum models of cognitive behavior, and establishing a new framework of brain-like information interaction model, with the application in typical tasks for information interaction scenarios.
分类： 生物学 >> 生物物理学 提交时间： 2016-05-05
Deng, Xiaofeng
Xu, Long
Zhang, Yan
Wang, Shuo
Zhao, Yuanli
Cao, Yong
Zhang, Dong
Wang, Rong
Ye, Xun
Wu, Jun
Zhao, Jizong
Deng, Xiaofeng
Xu, Long
Zhang, Yan
Wang, Shuo
Zhao, Yuanli
Cao, Yong
Zhang, Dong
Wang, Rong
Ye, Xun
摘要： The authors attempted to demonstrate the difference in language cortex reorganization between cerebral malformations (AVMs), cavernous malformations (CMs), and gliomas by blood oxygen level-dependent (BOLD) functional magnetic resonance imaging. Clinical and imaging data of 27 AVM patients (AVM-L group), 29 CM patients (CM-L group), and 20 glioma patients (Glioma-L group) were retrospectively reviewed, with lesions overlying the left inferior frontal gyrus (Broca area). As a control, patients with lesions involving the right inferior frontal gyrus were also enrolled, including 14 AVM patients (AVM-R group), 20 CM patients (CM-R group), and 14 glioma patients (Glioma-R group). All patients were right-handed. Lateralization indices (LI) of BOLD signal activations were calculated separately for Broca and Wernicke areas. In AVM-L group, right-sided lateralization of BOLD signals was observed in 10 patients (37.0 %), including 6 in the Broca area alone, 1 in the Wernicke area alone, and 3 in both areas. Three patients (10.3 %) of CM-L group showed right-sided lateralization in both Broca and Wernicke areas, and 1 patient (5.0 %) of Glioma-L group had right-sided lateralization in the Wernicke area alone. A significant difference of right-sided lateralization was observed between the AVM-L group and CM-L group (P = 0.018) and also between the AVM-L group and Glioma-L group (P = 0.027). No patient in AVM-R, CM-R, or Glioma-R groups showed right-sided lateralization. Language cortex reorganization may occur in AVM, CM, and glioma patients when the traditional language cortex was involved by lesions, but the potential of reorganization for CM and glioma patients seems to be insufficient compared with AVM patients.
分类： 心理学 >> 认知心理学 提交时间： 2024-05-02
摘要： Face-name memory is a special kind of memory that includes visual and semantic memory. Existing research suggests that name retrieval is located at the final stage of face recognition, but the exact timing has not been fully investigated. This study used ERPs and a method of spatially localizing brain activity to investigate neural mechanisms underlying face-name memory. Participants were given four tasks: perceiving unfamiliar faces, learning face-name pairs, recalling a name by a face, and recognizing familiar faces but without names. We found that recently learned face-name pairs had the same highly activated brain regions as long-term familiar faces, but the long-term familiar faces exhibit larger amplitudes on the P100 component in the ventral occipital cortex and the N400 component in the thalamus and Gpi. Faces that can be recognized by name elicit a stronger response in the N400 component, particularly in the left hemisphere-dominant thalamus, Gpi, hippocampus, and putamen, compared to faces that are only familiar but not known by name. Results suggest that N400 may represent the retrieval of semantic information related to the name and the depth of retrieval of face-name pairs.
分类： 心理学 >> 心理学其他学科 提交时间： 2021-02-25
摘要： 目前关于运动员经验优势的脑机制还存在争议，尤其对于涉及较多认知过程参与的高策略性技能项目运动员，其大脑白质结构可塑性变化还需进一步探究。研究横向对比了乒乓球运动员和非运动员大脑白质纤维束的弥散张量成像数据。结果发现，相比于非运动员，乒乓球运动员在连接背侧和腹侧通路脑区的双侧皮质脊髓束、左侧上纵束、左侧下纵束和双侧额枕下束的各向异性值（FA）更大，进一步分析发现，部分腹侧通路白质纤维束FA增加的原因是径向扩散系数（RD）下降。研究结果支持了动作双通路模型。提示经过长期高策略性技能训练，乒乓球运动员在背侧和腹侧通路上的白质纤维束结构完整性增强。
分类： 生物学 >> 生物物理学 >> 神经科学 提交时间： 2016-05-12
Guo, Chao
Du, Yifei
Yuan, Deliang
Li, Meixia
Gong, Haiyun
Gong, Zhefeng
Liu, Li
Guo, Chao
Du, Yifei
Yuan, Deliang
Liu, Li
摘要： Orientation, the spatial organization of animal behavior, is an essential faculty of animals. Bacteria and lower animals such as insects exhibit taxis, innate orientation behavior, directly toward or away from a directional cue. Organisms can also orient themselves at a specific angle relative to the cues. In this study, using Drosophila as a model system, we established a visual orientation conditioning paradigm based on a flight simulator in which a stationary flying fly could control the rotation of a visual object. By coupling aversive heat shocks to a fly's orientation toward one side of the visual object, we found that the fly could be conditioned to orientate toward the left or right side of the frontal visual object and retain this conditioned visual orientation. The lower and upper visual fields have different roles in conditioned visual orientation. Transfer experiments showed that conditioned visual orientation could generalize between visual targets of different sizes, compactness, or vertical positions, but not of contour orientation. Rut-Type I adenylyl cyclase and Dnc-phosphodiesterase were dispensable for visual orientation conditioning. Normal activity and scb signaling in R3/R4d neurons of the ellipsoid body were required for visual orientation conditioning. Our studies established a visual orientation conditioning paradigm and examined the behavioral properties and neural circuitry of visual orientation, an important component of the insect's spatial navigation.
分类： 医学、药学 >> 临床医学 提交时间： 2023-10-09 合作期刊: 《中国全科医学》
摘要： The relationship between fatigue and diseases continues to receive widespread attention and fatigue is becoming an important public health issue. The World Health Organization added overexertion to the International Classification of Diseases in May, 2019, which had took effect globally in 2022. The concept of chronic fatigue syndrome （CFS） was proposed earlier, while its etiology and pathogenesis still remain unclear till now, resulting in lacking of specific therapies, which may be due to the involvement of multiple systems and the difficulties in distinguishing CFS symptoms from anxiety/depression, the complexity of the diagnosis and treatment of thedisease and researches on it are also increased. This review initially investigates the characteristics of CFS associated with anxiety/depression, further explores the similarities and differences in indicator change characteristics between CFS and anxiety/depression in terms of the current research status on biological indicators, imaging abnormalities and treatment, in order to provide new ideas for the diagnosis and typing of CFS, and provide suggestions for conducting clinical and basic researches on the disease.
分类： 生物学 >> 生物物理学 提交时间： 2016-05-12
摘要： What is a number? The number sense hypothesis suggests that numerosity is "a primary visual property" like color, contrast, or orientation. However, exactly what attribute of a stimulus is the primary visual property and determines numbers in the number sense? To verify the invariant nature of numerosity perception, we manipulated the numbers of items connected/enclosed in arbitrary and irregular forms while controlling for low-level features (e.g., orientation, color, and size). Subjects performed discrimination, estimation, and equality judgment tasks in a wide range of presentation durations and across small and large numbers. Results consistently show that connecting/enclosing items led to robust numerosity underestimation, with the extent of underestimation increasing monotonically with the number of connected/enclosed items. In contrast, grouping based on color similarity had no effect on numerosity judgment. We propose that numbers or the primitive units counted in numerosity perception are influenced by topological invariants, such as connectivity and the inside/outside relationship. Beyond the behavioral measures, neural tuning curves to numerosity in the intraparietal sulcus were obtained using functional MRI adaptation, and the tuning curves showed that numbers represented in the intraparietal sulcus were strongly influenced by topology.
分类： 生物学 >> 生物物理学 提交时间： 2016-05-12
Zhao, Linnan
Li, Jun
Ma, Yuanlin
Gao, Kai
Zhang, Zhengrong
Lu, Tianlan
Ruan, Yanyan
Yue, Weihua
Wang, Lifang
Zhang, Dai
Zhao, Linnan
Li, Jun
Ma, Yuanlin
Gao, Kai
Zhang, Zhengrong
Lu, Tianlan
Ruan, Yanyan
Yue, Weihua
Wang, Lifang
Zhang, Dai
摘要： Radial migration of pyramidal neurons is an important event during the development of cerebral cortex. Neurons experience series of morphological and directional transitions to get to their final laminar positions. Here we report that the histone methyltransferase enhancer of zest homolog 2 (Ezh2) is involved in the regulation of cortical radial migration. We show that Ezh2 knockdown leads to disturbed neuronal orientation, which results in the impairment of radial migration. Further results reveal that this migration deficiency may be due to the derepression of Reelin transcription in the migrating neurons. Our study provides evidence that epigenetic regulation of Reelin by Ezh2 maintains appropriate Reelin expression pattern to fulfill proper orientation of migrating neurons.
分类： 生物学 >> 生物物理学 提交时间： 2016-05-11
Wang, Shuihua
Li, Yang
Du, Sidan
Wang, Shuihua
Zhang, Yudong
Chen, Mengmeng
Wu, Jane
Chen, Mengmeng
Wu, Jane
Chen, Mengmeng
Zhang, Yudong
Han, Liangxiu
摘要： Identification and detection of dendritic spines in neuron images are of high interest in diagnosis and treatment of neurological and psychiatric disorders (e.g., Alzheimer's disease, Parkinson's diseases, and autism). In this paper, we have proposed a novel automatic approach using wavelet-based conditional symmetric analysis and regularized morphological shared-weight neural networks (RMSNN) for dendritic spine identification involving the following steps: backbone extraction, localization of dendritic spines, and classification. First, a new algorithm based on wavelet transform and conditional symmetric analysis has been developed to extract backbone and locate the dendrite boundary. Then, the RMSNN has been proposed to classify the spines into three predefined categories (mushroom, thin, and stubby). We have compared our proposed approach against the existing methods. The experimental result demonstrates that the proposed approach can accurately locate the dendrite and accurately classify the spines into three categories with the accuracy of 99.1% for "mushroom" spines, 97.6% for "stubby" spines, and 98.6% for "thin" spines.
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