Subjects: Medicine, Pharmacy >> Clinical Medicine submitted time 2024-02-20 Cooperative journals: 《中国全科医学》
Abstract： Background Chronic kidney disease has become a major global concern，and the prevalence of kidney disease in China is the highest in the world. About 89.5% of patients require hemodialysis. In recent years，the prevalence of frailty in maintenance hemodialysis（MHD）patients has risen significantly，seriously affecting the quality of life and prognosis of patients. Objective To explore the prevalence of frailty and the influencing factors of maintenance hemodialysis patients in China through Meta-analysis. Methods Cross-sectional and cohort studies on the prevalence and influencing factors of frailty in Chinese MHD patients were systematically searched in CNKI，VIP，CBM，Wanfang Data，Web of Science，PubMed， Cochrane Library，Embase，and CINAHL databases. The search deadline was from the respective databases to July 2023. Literature screening，data extraction and quality assessment were performed independently by two researchers. Stata 15.0 was used for meta-analysis. Results Thirty-two papers were included，and including 6 746 patients，among which 2 566 experienced frailty，involving 37 influencing factors. Meta-analysis showed that the prevalence of frailty in MHD patients in China was 37.4%（95%CI=30.3%-44.5%）. Age（OR=1.09，95%CI=1.06-1.13），age>60 years（OR=3.81，95%CI=2.31- 6.30），female（OR=2.13，95%CI=1.47-3.08），living alone（OR=2.42，95%CI=1.22-4.80），sleep（OR=1.28， 95%CI=1.08-1.50），depression（OR=1.97，95%CI=1.26-3.08），age on dialysis（OR=3.25，95%CI=1.82-5.79），social support（low level）（OR=1.99，95%CI=1.39-2.86），comorbidities（OR=1.79，95%CI=1.40-2.30），malnutrition（OR=1.17， 95%CI=1.07-1.28），Charlson comorbidity index（CCI）（OR=1.32，95%CI=1.01-1.71），C-reactive protein（CRP） （OR=1.15，95%CI=1.09-1.21），hemoglobin（Hb<110 g/L）（OR=2.70，95%CI=1.67-4.36），comorbid diabetes （OR=2.16，95%CI=1.48-3.16），comorbid cerebrovascular disease（OR=2.66，95%CI=1.85-3.82），comorbid coronary heart disease（OR=3.50，95%CI=2.15-5.70） were risk factors for frailty MHD；economic income （OR=0.02，95%CI=0.01- 0.14），social support（high level）（OR=0.86，95%CI=0.76-0.97），well nutrition （OR=0.47，95%CI=0.26-0.85）， ability to perform activities of daily living（ADL）（OR=0.80，95%CI=0.70-0.91），serum albumin（ALB）（OR=0.84， 95%CI=0.77-0.91），Hb ≥ 110 g/L（OR=0.70，95%CI=0.54-0.90），25-hydroxyvitamin D［25-（OH）VD］（OR=0.69， 95%CI=0.49-0.98） were protective factors for MHD frailty. Conclusion The prevalence of frailty in MHD patients in China is at a high level，in which age，female，living alone，economic income，sleep，depression，age on dialysis，social support， comorbidities，nutritional risk scores，ADL，CCI，CRP，ALB，Hb，25-（OH）VD，comorbid diabetes mellitus，comorbid cerebrovascular disease，and comorbid coronary heart disease are mainly factors influencing of MHD frailty patients in China， and in the future，there is a need for early screening and intervention to slow down or avoid the occurrence of hemodialysis frailty in patients.
Subjects: Medicine, Pharmacy >> Clinical Medicine submitted time 2023-12-19 Cooperative journals: 《中国全科医学》
Abstract： Background Older adults are at high risk for atrial fibrillation（AF）. Improving the efficiency of AF screening among the community-based elderly population can help to reduce the risk of AF-related stroke. Objective To compare the screening efficiency of different AF screening methods in the elderly population. Methods A total of 1 300 cases of older adults were selected from three neighborhood committees of Xiangshan，Huangshan，and Luoshan in Jinyang Community， Pudong New Area，Shanghai from July 2022 to January 2023. AF screening was detected using palpation of radial artery pulse， electronic sphygmomanometer with AF detection function，and single-lead ECG recorder. A positive result of any one of the three methods was considered positive for AF，and finally an electrocardiogram（ECG） was performed and interpreted by a physician in the ECG room. The receiver operating characteristic（ROC） curves of the subjects with different screening methods were plotted，the area under the ROC curve（AUC） was calculated to evaluate the screening value；the association between AF stroke score（CHA2DS2-VASc score） and AF was analyzed using the chi-square test for trend. Results AF was detected in 93 of the 1 300 people，including 57 asymptomatic people；375 people had a positive palpated pulse，331 people had a positive electronic blood pressure monitor with AF detection function，and 128 people had a positive result of single-lead ECG recorder. The AUCs for the diagnostic value of palpation pulse，electronic sphygmomanometer with AF detection function and single#2;lead ECG recorder in the elderly was 0.750（95%CI=0.697-0.803，P<0.01），0.832（95%CI=0.790-0.874，P<0.01），0.939（95%CI=0.916-0.973，P<0.01）；the incidence of AF in the elderly gradually increased as the CHA2DS2-VASc score increased（χ2 trend=197.46，P<0.01）. Conclusion Screening for AF using single-lead ECG recorder is convenient，efficient and accurate，and can be promoted in AF screening among community-based elderly population.
Subjects: Digital Publishing >> New Media submitted time 2023-10-08 Cooperative journals: 《中国传媒科技》
Abstract：移动互联网技术和新媒体技术的诞生给传统的广播电视传播媒介带来了极大冲击,迫使广播电视这一传统媒介纷纷寻求与其他传播媒介融合,共同开创"融媒体"发展的崭新时代。在这样的背景之下,广播电视编辑的主体意识和受众意识受到了挑战,必须做出相应的完善才能适应当下正在进行的融媒体建设。本文从融媒体、主体意识、受众意识三者的相关概念出发,对主体意识和受众意识在广播电视编辑工作中发挥的作用展开解析,对广播电视编辑在主体意识和受众意识方面容易出现的问题进行分析,最后提出"融媒体"下解决问题的具体举措。
Subjects: Nursing >> Nursing submitted time 2023-09-17
Abstract： Objective Through nursing clinical practice and comparative observation, explore the effect of cupping along the meridians on postoperative lower limb pain in patients with lumbar disc herniation.Methods Using the convenient sampling method, a total of 134 patients with lumbar disc herniation who were hospitalized in Shandong Wendeng Osteopathic Hospital from January to August 2018 were selected as the research objects. According to the simple random number table method, they were divided into the control group and the observation group, with 67 cases in each group. The patients in the observation group were treated with cupping along the meridian. The lumbar spine function score, pain score and adverse reactions were compared between the two groups before treatment and after 1 week of treatment.Results A total of 67 patients in the observation group and 67 patients in the control group completed the study. After 1 week of intervention, the scores of the observation group were significantly lower than those of the control group (P<0.05).Conclusion Conclusion: Cupping along the meridians has a good therapeutic effect on postoperative lower limb pain in patients with lumbar disc herniation.
Peer Review Status:
Awaiting Review
Subjects: Psychology >> Developmental Psychology submitted time 2023-03-28 Cooperative journals: 《心理科学进展》
Abstract： Heightening the quality of employee voice has been recognized as an important way to improve organizational effectiveness. However, previous studies have mainly focused on how to promote employees’ voice participation and quantity of voice, while ignoring the most essential issue - voice quality. To solve this problem, the present study aims to systematically research voice quality, including the connotation, measurement and antecedents of employee voice quality. The first study defines the connotation of employee voice quality based on grounded theory, and develops a scale of employee voice quality. The second study, drawing on implicit voice theory, explores the theoretical mechanisms linking leader and employee critical thinking to employee voice quality on both team and individual levels. This paper makes theoretical contributions by developing an employee voice quality framework and expanding the application of critical thinking and implicit voice theory.
Subjects: Psychology >> Management Psychology submitted time 2020-03-30
Abstract： " Heightening the quality of employee voice has been recognized as an important way to improve organizational effectiveness. However, previous studies have mainly focused on how to promote employees’ voice participation and quantity of voice, while ignoring the most essential issue – voice quality. To solve this problem, the present study aims to systematically research voice quality, including the connotation, measurement and antecedents of employee voice quality. The first study defines the connotation of employee voice quality based on grounded theory, and develops a scale of employee voice quality. The second study, drawing on implicit voice theory, explores the theoretical mechanisms linking leader and employee critical thinking to employee voice quality on both team and individual levels. This paper makes theoretical contributions by developing an employee voice quality framework and expanding the application of critical thinking and implicit voice theory.
Peer Review Status:Awaiting Review
Subjects: Biology >> Bioengineering submitted time 2018-01-12 Cooperative journals: 《中国生物工程杂志》
Abstract：由于基础研究环境和临床环境之间存在的转化差异，使得药物在临床阶段取得成功仍然具有挑战性。诱导多能干(iPS)细胞的诞生为药物研发领域带来了新的希望，使研究者能在体外人性化各种药理学和毒理学模型。人iPS衍生细胞的可获得性，特别是可以定向分化成特定的功能性细胞，组织和器官，为疾病机制研究与细胞治疗提供了全新的途径。另一方面，转化研究中的生物标记物提供了评估临床前基础研究环境和临床环境下毒理学和药理学影响的可衡量的指标，而iPS细胞给生物标记物的研究带来了全新的思路。本综述从转化研究的角度概述了基于iPS细胞药物发现的现行策略，阐明iPS细胞的潜力以及生物标志物在药物发现和发展整个过程中的作用，突出在该领域有待改进的地方，以期为进一步相关性研究提供一定参考，为新药研发提供新的思路与方法。
Subjects: Biology >> Bioengineering submitted time 2017-11-21 Cooperative journals: 《中国生物工程杂志》
Abstract：目的 利用微流控芯片技术构建易调控、接近在体微环境的体外血脑屏障模型。 方法 微流控芯片体外模型采用上下双培养池结构，由多聚碳酸酯膜分隔，两套流路系统控制流体。细胞采用原代分离纯化的大鼠脑血管内皮细胞和星形胶质细胞，免疫荧光技术进行鉴定，分别按次序注入微流控芯片上下培养池，按1μL/min的流速进行灌注培养，构建体外血脑屏障模型，并对此模型进行鉴定和评价。结果 原代分离纯化得到两种细胞，免疫荧光法鉴定细胞纯度达95%以上。共培养3天紧密连接开始形成，5天达到峰值，超微结构观察显示内皮细胞之间形成紧密连接，且荧光素钠渗透实验和TEER值测量表明屏障形成良好。 结论 成功构建微流控芯片体外血脑屏障模型，可成为一个新的平台应用于药物筛选、神经系统基础等多项研究中。
Subjects: Biology >> Bioengineering submitted time 2017-11-21 Cooperative journals: 《中国生物工程杂志》
Abstract：摘要：由于基础研究环境和临床环境之间存在的转化差异，使得药物在临床阶段取得成功仍然具有挑战性。诱导多能干(iPS)细胞的诞生为药物研发领域带来了新的希望，使研究者能在体外人性化各种药理学和毒理学模型。人iPS衍生细胞的可获得性，特别是可以定向分化成特定的功能性细胞，组织和器官，为疾病机制研究与细胞治疗提供了全新的途径。另一方面，转化研究中的生物标记物提供了评估临床前基础研究环境和临床环境下毒理学和药理学影响的可衡量的指标，而iPS细胞给生物标记物的研究带来了全新的思路。本综述从转化研究的角度概述了基于iPS细胞药物发现的现行策略，阐明iPS细胞的潜力以及生物标志物在药物发现和发展整个过程中的作用，突出在该领域有待改进的地方，以期为进一步相关性研究提供一定参考，为新药研发提供新的思路与方法。
Subjects: Biology >> Bioengineering submitted time 2017-11-21 Cooperative journals: 《中国生物工程杂志》
Abstract：目的 利用微流控芯片技术构建易调控、接近在体微环境的体外血脑屏障模型。 方法 微流控芯片体外模型采用上下双培养池结构，由多聚碳酸酯膜分隔，两套流路系统控制流体。细胞采用原代分离纯化的大鼠脑血管内皮细胞和星形胶质细胞，免疫荧光技术进行鉴定，分别按次序注入微流控芯片上下培养池，按1μL/min的流速进行灌注培养，构建体外血脑屏障模型，并对此模型进行鉴定和评价。结果 原代分离纯化得到两种细胞，免疫荧光法鉴定细胞纯度达95%以上。共培养3天紧密连接开始形成，5天达到峰值，超微结构观察显示内皮细胞之间形成紧密连接，且荧光素钠渗透实验和TEER值测量表明屏障形成良好。 结论 成功构建微流控芯片体外血脑屏障模型，可成为一个新的平台应用于药物筛选、神经系统基础等多项研究中。
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