On the origin of SARS-CoV-2–The blind watchmaker argument

作者： Chung-I Wu ¹ Haijun Wen ¹ Jian Lu ² Xiao-dong Su ² Alice C. Hughes ³ Weiwei Zhai ⁴ Chen Chen ⁵ Hua Chen ⁶ Mingkun Li ⁶ Shuhui Song ⁶ Zhaohui Qian ⁷ Qihui Wang ⁸ Bingjie Chen ¹ Zixiao Guo ¹ Yongsen Ruan ¹ Xuemei Lu ⁹ Fuwen Wei ¹⁰ Li Jin ¹¹ Le Kang ¹² Yongbiao Xue ⁶ Guoping Zhao ¹³ Ya-Ping Zhang ⁹
作者单位：

1. State Key Laboratory of Biocontrol, School of Life Sciences, Sun Yat-sen University, Guangzhou 510275, China

2. State Key Laboratory of Protein and Plant Gene Research, Center for Bioinformatics, School of Life Sciences, Peking University, Beijing 100871, China

3. Landscape Ecology Group, Center for Integrative Conservation, Xishuangbanna Tropical Botanical Garden, Chinese Academy of Sciences, Menglun, Mengla, Yunnan 666303, China

4. Key Laboratory of Zoological Systematics and Evolution, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China

5. Biomedical inovation center, Beijing Shijitan Hospital, Capital Medical University, Beijing, China

6. Beijing Institute of Genomics, Chinese Academy of Sciences, and China National Centre for Bioinformation, Beijing 100101, China

7. Institute of Pathogen Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100176, China

8. CAS Key Laboratory of Pathogen Microbiology and Immunoly, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, China

9. State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Science, Kunming 650223, China

10. CAS Key Laboratory of Animal Ecology and Conservation Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China

11. MOE Key Laboratory of Contemporary Anthropology, Department of Anthropology and Human Genetics, School of Life Sciences, Fudan University, Shanghai 200433, China

12. State Key Laboratory of Integrated Management of Pest Insects and Rodents, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China

13. Key Laboratory of Synthetic Biology, Institute of Plant Physiology and Ecology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200032, China
通讯作者： Chung-I Wu Email:wzhongyi@mail.sysu.edu.cn
提交时间：2021-07-17 13:58:53

摘要: In the comparison with SARS-CoV of 2003, SARS-CoV-2 is extremely well adapted to the human populations and its adaptive shift from the animal host to humans must have been even more extensive. By the blind watchmaker argument, such an adaptive shift can only happen prior to the onset of the current pandemic and with the aid of step-by-step selection. In this view, SARS-CoV-2 could not have possibly evolved in an animal market in a big city and even less likely in a laboratory. Discussions of the origin of SARS-CoV-2 need to factor in the long process of adaptive shift and some models have indeed advanced in that direction.

SARS-CoV-2

来自： 刘静羽
分类： 生物学 >> 病毒学医学、药学 >> 预防医学与公共卫生学
引用： ChinaXiv:202107.00013 (或此版本 ChinaXiv:202107.00013V1)
DOI:10.12074/202107.00013V1
CSTR:32003.36.ChinaXiv.202107.00013.V1
推荐引用方式： Chung-I Wu,Haijun Wen,Jian Lu,Xiao-dong Su,Alice C. Hughes,Weiwei Zhai,Chen Chen,Hua Chen,Mingkun Li,Shuhui Song,Zhaohui Qian,Qihui Wang,Bingjie Chen,Zixiao Guo,Yongsen Ruan,Xuemei Lu,Fuwen Wei,Li Jin,Le Kang,Yongbiao Xue,Guoping Zhao,Ya-Ping Zhang.(2021).On the origin of SARS-CoV-2–The blind watchmaker argument.中国科学院科技论文预发布平台.[ChinaXiv:202107.00013] (点此复制)

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2021-07-17 13:58:53

ChinaXiv:202107.00013V1

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