Subjects: Medicine, Pharmacy >> Preventive Medicine and Hygienics submitted time 2023-12-28 Cooperative journals: 《中国全科医学》
Abstract： Background Idiopathic inflammatory myopathy（IIM） is a group of connective tissue diseases characterized by muscle inflammation and muscle weakness，lung involvement is an important factor affecting the prognosis of patients. IIM can be classified into different clinical subtypes based on myositis-specific antibodies（MSAs），there are significant differences in clinical manifestations，organ involvement，prognosis and the risk of interstitial lung disease among different clinical subtypes. Objective To explore the characteristics of IIM and its different clinical subtypes，the risk factors for the development of interstitial lung disease. Methods The clinical data of patients hospitalizedin department of rheumatology and immunology of the First Affiliated Hospital of Kunming Medical University and diagnosed with IIM from April 2018 to February 2021 were collected. The included patients were divided into four clinical subtypes based on MSAs，including anti-MDA5-positive dermatomyositis （DM），anti-MDA5-negative DM，immune-mediated necrotizing myositis （IMNM） and anti synthetase syndrome （ASS） subtypes. The general data，clinical manifestations，laboratory examination results were compared among different clinical subtypes. Multivariate Logistic regression model was established to explore the risk factors for ILD in patients with IIM. Results The 150 patients with IIM were divided into 4 clinical subtypes，including 30 patients with anti MDA5-positive DM subtype（20%），58 patients with anti-MDA5-negative DM subtype（38.7%），14 patients with IMNM subtype（9.3%），and 48 patients with ASS subtype（32.0%）. There were significant differences in the incidence of muscle weakness，myalgia，ILD，heliotrope rash，shawl sign，Gottron papules or Gottron sign，arthralgia，periungual red spot and dysphagia among the four clinical subtypes（P<0.05）. The incidence of ILD in patients with anti-MDA5-positive DM and ASS subtypes was higher than patients with anti-MDA5-negative DM and IMNM subtypes，respectively（P<0.05）；The incidences of heliotrope rash and shawl sign in patients with anti-MDA5-positive DM and anti-MDA5-negative DM subtypes were higher than patients with IMNM and ASS subtypes（P<0.05）；The incidences of arthralgia in patients with anti-MDA5-positive DM subtype was higher than patients with anti-MDA5-negative DM subtype（P<0.05）. There were significant differences in the levels of WBC，ALT，AST，serum creatinine，LDH，CK，C4，ferritin，T cell，CD8+ T cell，nature kill （NK） cell and incidence of ILD among patients with different subtypes（P<0.05）. Multivariate Logistic regression analysis showed that anti MDA5 antibody positive，anti-synthetase antibody positive，lung infection，ferritin>403.2 μg/L，IgG>14.15 g/L，LDH>359.5 IU/L were all risk factors for ILD in IIM. Conclusion The clinical manifestations of patients with different clinical subtypes differ significantly. DM patients with anti-MDA5 antibody positive are more likely to develop rash，arthralgia，ILD and leukopenia. MDA5 antibody positive，anti-synthetase antibody positive，lung infection and elevated ferritin，LDH and IgG levels are the risk factors for IIM with ILD.
Subjects: Library Science，Information Science >> Library Science submitted time 2023-08-27 Cooperative journals: 《图书情报工作》
Abstract： [Purpose/significance] Exploring the topic and evolution trend of hypertension literature is of great significance for users to understand the profile, research hot-spots and frontiers of chronic disease, and can promote the knowledge communication among experts.[Method/process] This paper takes the Hypertension and 26717 articles from PubMed database as the research object, extracts high-frequency Mesh Terms to construct a co-occurrence matrix. Social network analysis is applied to detect the community and topic distribution of the hypertension study literature, and the expanded topic modeling Dirichlet-multinomial regression is also used to explore the topic distribution and evolution trends. Then similarities and differences of the SNA and DMR method in topic detection are analyzed.[Result/conclusion] It is found that the hypertension literature is mainly concentrated on three communities, which can be divided into five research topics, such as risk factors, research methods, basic situation of patients, diagnosis and treatment, and animal experiments. The relative distribution of the topic varies with time change. It is also found that the topic obtained from SNA and DMR are basically similar. But the Mesh Terms obtained from SNA method are more specific and clearer, while the DMR is more broadly and have an advantage in exploring the evolution of various themes.
Subjects: Library Science，Information Science >> Library Science submitted time 2023-08-26 Cooperative journals: 《图书情报工作》
Abstract： [Purpose/significance] This paper explores the community structure and community membership of the research interest similarity network of core authors in information science.[Method/process] We firstly download all papers of information science retrieved in CSSCI database using the China Library Category number. By recognizing the core-authors in this discipline with Price law, we compute the similarity between each two authors with bag-of-words model and construct the research interest similarity network of core authors. Then we divide it into four research community. Finally, we compute the every author's membership degree to different communities and his/her fuzzy entropy.[Result/conclusion] We discover that the domestic information science discipline has four research field:information organization and retrieval, bibliometrics and scientific evaluation, competitive intelligence and knowledge management, and the information science. Most authors' research isn't limited to one field. Finally, the authors in C2 and C3 merely take each other as secondary membership community, and it implies that the boundary between competitive intelligence and bibliometrics is very obvious.
Subjects: Library Science，Information Science >> Library Science submitted time 2023-08-26 Cooperative journals: 《图书情报工作》
Abstract： [Purpose/significance] As the "gatekeeper" of scholarly journals, the peer review has been criticized for lacking the transparency quality assurance. The open peer review, to some extent, could overcome the limitation and live up to the demands of open science and giving reviewers credit. Thus, it is critical for journals to investigate the attitudes of researchers towards the open peer review before it is implemented.[Method/process]Based on the literature review, we firstly defined the concept, the pros and cons of the open peer review; then, we conducted an online survey focusing on the information disclosure willingness during the open review process of respondents, and analyzed the collected data.[Result/conclusion]304 valid questionnaires from China have been received. All respondents have authored papers and 70% of them have peer review experience, including 40% have review experience for international journals. The result indicates that about half (50.33%) of the Chinese researchers maintain a positive attitude towards the open peer review, and the degree of acceptance varies at different stages of the open peer review process. While the discipline of researchers affects their attitudes towards the open peer review, the peer review experience for international journals makes little difference on the results. The results and analysis in this study could serve as a reference for Chinese journals to put the open peer review into practice.
Subjects: Library Science，Information Science >> Library Science submitted time 2023-07-26 Cooperative journals: 《图书情报工作》
Abstract： [Purpose/significance] Interdisciplinary research has become an important paradigm and inevitable trend of modern scientific innovation research. Exploring the development pattern and path of interdisciplinary fields is of great significance for understanding the dynamic process of interdisciplinarity formation and development.[Method/process] Taking the field of Eye Tracking (ET) as an example, the citation relationship of the literature was extracted and the subject was marked, and the citation networks of the literature and the subject level were constructed. To perform an analysis on the interdisciplinary development pattern of major disciplines in the ET field from a macro level, the cross-same field reference ratio, cross-same field citation ratio and Price's Index were calculated. Then this study examined the relationship between disciplines within and between different stages, and explored the relationship structure and role evolution of interdisciplinary development in different stages. Finally, to reveal the specific development path of ET development from the micro level, betweenness centrality analysis was performed to identify important documents that connect different disciplines. Moreover, this study examined the citation relations between important documents, highly cited documents, and references.[Result/conclusion] The development of ET field has three stages:incubation period, development period and maturity stage, and presents three types of subject development pattern:independent, interdisciplinary and learning discipline. The citation relationships between different disciplines are more dense and evenly distributed over time. Neuroscience, psychology and clinical medicine are important knowledge exporter during the interdisciplinary evolution. The vertical development of ET field is the basic theoretical innovation of independent disciplines, and the horizontal development is characterized by the deep integration of four types of disciplines, and the development path is presented as "independent-linear-mesh" pattern.
Subjects: Library Science，Information Science >> Information Science submitted time 2023-04-01 Cooperative journals: 《图书情报工作》
Abstract： [Purpose/significance] The rapid development of AI, big data etc. makes an increasingly fierce confrontation between business development and privacy protection. This paper finds the differences in privacy concern and sentimental characteristics of users in different situations through the comparative analysis of sentiment and topic of Weibo comments on different types of online privacy controversial events.[Method/process] Firstly, Weibo comments related to privacy controversial events from 2012 to 2019 were collected and preprocessed as experimental data. Secondly, the sentiment value of each comment was calculated based on the sentiment dictionary. Then, the privacy controversial events were classified into privacy collection categories, privacy exposure categories and privacy agreement categories. The sentimental analysis was conducted under different situations. Finally, a bipartite network of "discussed object-emotional expression" was constructed, and a single vertex network was constructed by the bipartite network projection, and the analysis of both were carried out by combining the indexes such as node centrality.[Result/conclusion] The result shows that users' overall privacy concern shows an upward trend; users of different types of privacy controversial events have different levels of negative sentimental intensity; the hotspots of users' concern vary widely across privacy controversial events, and emotional expression have different characteristics. These findings indicate that there are significant differences in user privacy concern and sentimental performance in different situations.
Subjects: Mechanics >> Applied Mechanics submitted time 2023-03-20 Cooperative journals: 《应用力学学报》
Abstract： In order to the study the characteristics of open-rotor noise in low speed , CFD ( computationalfluid dynamics)/CAA ( computing aerodynamic acoustics ) hybrid method of the open-rotor tone noise wasset up.N-S equation is expanded by NLH method in the frequency domain, and the unsteady componentsare obtained.'These unsteady components and steady load are used to construct Lighthill sound source.Fi-nally ,FW-H integration method is used to calculate far-field noise radiation. The noise experimental plat-form is built and test scheme is designed.The noise directivity in the range of 0� -90� is measured by usingthe far-field directivity array surround scale prototype. The characteristic of the noise of open-rotor is ana-lyzed by comparing the numerical simulation results and experimental results. The results show that inter-action noise is the major component of open-noise.'The simulation results are basically consistent with thedistribution trend of the experimental results at key frequency ,the error is within 3 dB.'The numerical sim-ulation method of aerodynamic noise based on nonlinear harmonic method is developed to solve unsteadydisturbance in frequency domain , which can provide some help for rapid and accurate prediction of open rotor noise.
Subjects: Other Disciplines >> Synthetic discipline submitted time 2023-03-19 Cooperative journals: 《中国科学院院刊》
Abstract： This perspective first introduces the current status of photosynthesis research in China and in the world, followed by a brief discussion of the major progress of photosynthesis synthetic biology. Then we demonstrate the major weakness of current photosynthesis synthetic biology research in China, which includes fragmented research topics, lack of strong link to its end application and shortage of research funding, etc. Photosynthesis research will play a crucial role for the future global food security, energy security, and maintenance of a sustainable ecosystem and environment. The future photosynthesis synthetic biology research can focus on optimization of existing photosynthetic systems, coordination of photosystem with the metabolisms consuming photosynthate, reconstruction of existing efficient photosynthetic systems, construction of novel photosynthetic systems, and creation of hybrid systems by combining photosynthetic systems and novel bio-material. To effectively promote photosynthesis systems biology research, we propose to establish a series of technical platforms and theories and corresponding policies.
Subjects: Other Disciplines >> Synthetic discipline submitted time 2023-03-19 Cooperative journals: 《中国科学院院刊》
Abstract： In synthetic biology, the dazzling methodological innovations in sequencing, editing and synthesis of genomes have resulted in an unprecedented capability in “design and manufacturing of genotype”. On the other hand, “testing of cellular phenotype and function” has increasingly become one major bottleneck. Single-cell technologies have tremendous implications and potentials in rapid testing of cellular function. However, ideally, such single-cell methods should allow non-invasive live-cell probing, be label-free, provide landscapelike phenotyping capability, distinguish complex functions, operate with high speed, sufficient throughput and low-cost, and finally, be able to couple with downstream omics analysis via cell sorting. In this perspective article, we focus on recent progress in label-free molecular spectroscopy-activated phenotyping, sorting and sequencing of single-cells, and discuss the key challenges and emerging trends of the area. We propose that alliance among the array of non-invasive spectroscopy methods or modes, when coupled with downstream high-throughput cell sorting and omics profiling, will establish and broaden a bridge that connects spectroscopy and genetics, in science, technologies, and communities. This bridge will lead to novel and creative solutions to high-throughput, landscape-like testing and screening of synthetic cells. Moreover, it will fulfill the promise of spectroscopy-enabled single-cell “phenome-genome” as a new type of biological big-data, and accelerate the pace of “data-driven” synthetic biology.
Subjects: Library Science，Information Science >> Information Science submitted time 2017-11-08 Cooperative journals: 《数据分析与知识发现》
Abstract：【目的】通过对网络游记进行情感分析, 发现游客对旅游地情感倾向的时间分布规律。【应用背景】越来越多人通过浏览大量网络游记来收集信息, 制定旅游计划。网络游记成为旅游者搭配旅游地及出游时间的重要参考内容, 也为商家提供了商机。【方法】提出面向网络游记时间特征的情感分析模型, 分析游客情感的时间变化规律。该模型包括5 个模块: 网络游记文本内容及旅游时间数据的采集、游记文本预处理、情感标注、按时间段统计游记情感特征分值、游记情感时间特征分析。并从网络抓取4 种类型旅游地游记对模型进行实验。【结果】在7类情感中, [好]的情感均值在各旅游地的各月份中总是远高于其他情感, 较为稳定; [好]、[乐]和[恶]在不同月份的波动程度较大; 情感随时间的波动与相应游记数量并不相关, 即传统的旅游地旺季和淡季的划分与游客的实际情感体验并不相关。【结论】该模型能够有效地反映旅游地的游客情感随时间变化的波动, 进而为旅游管理者、潜在旅游者信息获取提供新的信息参考渠道。
Subjects: Library Science，Information Science >> Information Science submitted time 2017-11-08 Cooperative journals: 《数据分析与知识发现》
Abstract：【目的】通过对网络游记进行情感分析, 发现游客对旅游地情感倾向的时间分布规律。【应用背景】越来越多人通过浏览大量网络游记来收集信息, 制定旅游计划。网络游记成为旅游者搭配旅游地及出游时间的重要参考内容, 也为商家提供了商机。【方法】提出面向网络游记时间特征的情感分析模型, 分析游客情感的时间变化规律。该模型包括5 个模块: 网络游记文本内容及旅游时间数据的采集、游记文本预处理、情感标注、按时间段统计游记情感特征分值、游记情感时间特征分析。并从网络抓取4 种类型旅游地游记对模型进行实验。【结果】在7类情感中, [好]的情感均值在各旅游地的各月份中总是远高于其他情感, 较为稳定; [好]、[乐]和[恶]在不同月份的波动程度较大; 情感随时间的波动与相应游记数量并不相关, 即传统的旅游地旺季和淡季的划分与游客的实际情感体验并不相关。【结论】该模型能够有效地反映旅游地的游客情感随时间变化的波动, 进而为旅游管理者、潜在旅游者信息获取提供新的信息参考渠道。
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