Subjects: Library Science，Information Science >> Information Processing submitted time 2023-01-12
Abstract：
Purpose/Significance The current slow progress of medical and health data assetization at home and abroad has seriously affected the implementation of the national medical and health big data strategy and industrial development. It is important to find out the key influencing factors affecting medical and health big data assetization and propose targeted countermeasures to tap the potential value of medical and health big data. Method/Process Firstly, based on the combination of literature analysis and expert interview, this paper identifies the influencing factors of medical and health big data assetization. Then, based on Fuzzy-DEMATEL-ISM method, the factor ranking and the association relationships among factors are identified. Finally, based on the analysis results of influencing factors, the promotion strategies of medical and health big data assetization are proposed. Result/Conclusion The study finds that medical and health data assetization is affected by 23 factors from 6 dimensions, including data acquisition, data storage, data processing, data management, data application and related environment. Among them, four factors, such as data sharing and data trading, are the most direct influencing factors of medical and health big data assetization; 11 factors, such as standard management and privacy protection, are the key factors connecting the bottom and top layers; 8 factors, such as technical support and data integration, are the root influencing factors of medical and health big data assetization. Based on the research conclusion, suggestions are put forward to promote medical and health big data assetization from 5 dimensions of the life cycle of medical and health big data around the related environment.
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Subjects: Medicine, Pharmacy >> Clinical Medicine submitted time 2022-12-20 Cooperative journals: 《中国全科医学》
Abstract：
Objective The purpose of this study was to investigate the clinical and pathological features and Short-term prognosis of patients with idiopathic membranous nephropathy with IgG4 combined with other IgG subtypes deposition.Methods Data were collected from 1099 patients with idiopathic membranous nephropathy (IMN) diagnosed in the Department of Nephrology, the First Affiliated Hospital of Zhengzhou University from January 2015 to June 2018 .The patients were divided into the simple IgG4 deposition group (259 cases ), the IgG4 combined with IgG1 deposition group (259 cases), the IgG4 combined with IgG2 deposition group (29 cases), the IgG4 combined with IgG3 deposition group (57 cases). The clinical manifestations, renal pathology and short-term prognosis of Idiopathic Membranous Nephropathy patients with different IgG subtypes of deposition were compared.Results 1.Compared with simple IgG4 patients , IgG4 combined with IgG1 deposition group patients had higer 24h urine protein levels（P＜0.05）; the positive proportion of C3、C4、λ in IgG4 combined with IgG1 deposition group patients was significantly higher than that in simple IgG4 group（P＜0.05）. 2.Compared with simple IgG4 patients , the positive proportion of C3 in IgG4 combined with IgG2 deposition group patients was significantly higher（P＜0.05）. 3. Compared with simple IgG4 patients , IgG4 combined with IgG3 deposition group patients had higer WBC, NE, MO, and 24h urine protein levels（P＜0.05）; the positive proportion of C3、C4、C1q, degree of tubular atrophy and interstitial fibrosis in IgG4 combined with IgG3 deposition group patients was significantly more serious than that in simple IgG4 group（P＜0.05）. 4. Compared with simple IgG4 deposition group, there was no significant difference in remission rate of proteinuria in each group after six months of treatment.Conclusion Compared with simple IgG4 deposition group, patients with IgG4 combined with other different IgG subtypes deposition present more severe clinical and pathological manifestation, and there was no significant difference in half-year remission rate. It may be related to the different ability of fixation of complement by different IgG subtypes, thus leading to the different inflammatory response.
Subjects: Medicine, Pharmacy >> Preclinical Medicine submitted time 2022-09-13 Cooperative journals: 《中国全科医学》
Abstract：
Background At present, there are some studies at home and abroad on the changes of intestinal flora in children with Henoch-Schönlein purpura compared with healthy children, but the number of studies is not large, and there is no relevant report on the intestinal flora in children with Henoch-Schönlein purpura nephritis in the early stage of the disease. Objective To study changes in the intestinal flora of children with Henoch-Schönlein purpura, to investigate the changes of intestinal flora of Henoch-Schönlein purpura and its role in the occurrence and development of disease. Methods 37 cases of newly diagnosed Henoch-Schönlein purpura treated in the Department of Pediatrics of the First Affiliated Hospital of Zhengzhou University from July 2019 to September 2019 were selected as the study group (group A), another 12 healthy children were selected as the control group (group B); follow-up for children with Henoch-Schönlein purpura for 6 months, grouping based on the presence or absence of kidney injury, children without kidney injury were group A1, and children with kidney injury were group A2, that was Henoch-Schönlein purpura nephritis group. High-throughput sequencing technology was used to sequence and analyze the intestinal flora of all subjects, LEfSe analysis to find species with significant differences between groups. Results ①PCoA analysis showed that the intestinal flora community structure in group A was different from that in group B, Adonis analysis showed the difference in the bacterial community structure between group A and group B was statistically significant (R2=0.044, P=0.005). PCoA analysis showed, differences in intestinal flora community structure between each of the group A1, group A2 and group B, Adonis analysis showed the difference in the bacterial community structure between group A1 and group B was statistically significant (R2=0.086，P=0.006), the difference in the bacterial community structure between group A2 and group B was statistically significant (R2=0.061，P=0.006), the difference in the bacterial community structure between group A1 and group A2 was statistically significant (R2=0.043，P=0.045). ②LEfSe analysis showed, compared group A and group B, in group A, the microorganisms of Blautia, Chryseobacterium, Agathobacter and Roseburia were significantly reduced, and the microorganisms of Megamonas and Enterococcus were significantly increased (LDA＞4.0); compared group A1 and group A2, the microorganisms of Christensenella and Bacteroides increased significantly in group A1, the microorganisms of Lactobacillus and Rothia increased significantly in group A2 (LDA＞4.0). Conclusions ①Intestinal flora disorders in children with Henoch-Schönlein purpura, manifested as reduction of beneficial bacteria producing butyrate in the intestinal flora, and more opportunistic pathogens, intestinal flora disorders might be related to the occurrence of Henoch-Schönlein purpura. ②In the early stage of the disease, the intestinal flora of children with Henoch-Schönlein purpura nephritis had been different from children with Henoch-Schönlein purpura without kidney injury, disorders of the intestinal flora in the early stages of the disease might be related to the occurrence of Henoch-Schönlein purpura nephritis.
Subjects: Medicine, Pharmacy >> Clinical Medicine submitted time 2022-08-01 Cooperative journals: 《中国全科医学》
Abstract： Background Stroke patients often suffer from malnutrition. Most of the previous studies focused on their nutritional status at the time of admission, but there is a lack of studies on the nutritional status during different periods of hospitalization. Objective To investigate the influencing factors of nutritional status in stroke patients at different time points(admission,7d,discharge) .Methods According to the inclusion and exclusion criteria, a total of 177 patients were included in this study. General information, nutritional status, swallowing status and degree of neurological deficit were collected, and the relationship between each factor and the nutritional status of stroke patients was analyzed.Results The results of univariate analysis showed that the nutritional status of the two groups of patients at admission was significantly different in terms of age, smoking and drinking history, and nutritional support methods (P<0.05);There were statistically significant differences in age, post-stroke pneumonia, nutritional support,Water Swallow Test score, and NIHSS score at 7 days (P<0.05-0.001); logistic regression analysis of nutritional support at discharge showed that WST score (OR=2.041, 95) %CI: 1.354-3.076) was a statistically significant difference in the way of predicting malnutrition, WST score and NIHSS score at admission (P<0.05~0.001);Multivariate Logistic regression analysis showed that WST score (OR=2.041,95%CI：1.354-3.076） was a predictor of malnutrition at admission;Age (OR=1.029,95%CI:0.994-1.065), nutritional support method, and NIHSS score (OR=1.108,95%CI:1.029-1.194) were predictors of malnutrition at 7d; nutritional support was independent predictors of malnutrition at discharge. Conclusion WST score is the influencing factor of malnutrition at admission, age, nutritional support mode and NIHSS score are malnutrition at 7d; nutritional support is malnutrition at discharge;
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