Subjects: Medicine, Pharmacy >> Clinical Medicine submitted time 2024-03-11 Cooperative journals: 《中国全科医学》
Abstract： Background Cardiotoxicity is a leading cause of mortality among breast cancer survivors and patients，making early risk assessment vital for the clinical prevention and treatment of cardiac toxicity. However，there is currently a lack of recognized tools for assessing the risk of cardiotoxicity in breast cancer chemotherapy patients in China. Objective To develop a cardiotoxic risk assessment scale for breast cancer patients undergoing chemotherapy and test its reliability and validity. Methods To develop a risk assessment scale for cardiotoxicity in breast cancer chemotherapy patients and to test its reliability and validity. Results Twenty medical staff experts were included in the semi-structured interviews. After two rounds of expert consultations，a 19-item risk assessment scale for cardiotoxicity in breast cancer chemotherapy patients was developed. In this study，there were 79 patients in the low-score group and 83 in the high-score group. Comparisons of endocrine treatment history and immunotherapy history showed no statistically significant differences between the two groups（P>0.05）. Correlation analysis showed that smoking history and immunotherapy history were not significantly correlated with total scores（P>0.05）. Eventually，three items-"smoking history，"endocrine treatment history" and "immunotherapy history"-were removed，resulting in a 16-item scale. The scale's Cronbach's alpha coefficient was 0.739; test-retest reliability was 0.983; inter-rater reliability was 0.984. The content validity results showed: I-CVI ranged from 0.83 to 1.00; S-CVI was 0.98. Predictive validity results showed: the scale's AUC was 0.887（95%CI=0.827-0.947，P<0.001），with a cut-off value of 32.50 points，Youden's index was 0.649，specificity was 89.1%，and sensitivity was 75.9%. Exploratory factor analysis results showed a KMO value of 0.700，and Bartlett's test of sphericity χ2value was 1037.898（df=120，P<0.001）. The study extracted five common factors with a cumulative variance contribution rate of 61.991%. Risk stratification results indicated scores of 32-38 points as low risk，39-56 points as medium risk，and ≥ 57 points as high risk. Conclusion The cardiotoxicity risk assessment scale for breast cancer patients undergoing chemotherapy has good reliability and validity，which can better predict the high-risk population of cardiotoxicity and provide an effective assessment tool for clinicians and nurses to effectively identify the high-risk population of breast cancer patients undergoing chemotherapy.
Subjects: Digital Publishing >> New Media submitted time 2023-10-08 Cooperative journals: 《中国传媒科技》
Abstract：掌握媒体融合发展主动权，首先要着力提升新闻创新能力、科学管理能力和立体传播能力，壮大主流思想舆论阵地， 实现传统媒体和新兴媒体优势互补、融合发展；其次要突破传统采编业务的瓶颈，克服新媒体发展乏力、技术支撑平台滞后 等难题；最后，要以融合性技术项目着力全媒体建设，以结构性调整实现采编流程再造，以体制机制创新推动媒体深度融合。
Subjects: Library Science，Information Science >> Library Science submitted time 2023-10-08 Cooperative journals: 《知识管理论坛》
Abstract： [Purpose/significance] This paper attempts to construct a model framework based on the theory of open innovation to evaluate the impact of open innovation platforms on corporate innovation performance, and provide development suggestions for builders and users of open platform communities. [Method/process] This article is based on the open innovation theory and knowledge management theory. First, it establishes the model of the impact of open innovation communities on corporate innovation performance and proposes research hypotheses. Then, Python is used to capture the data of an open innovation community for empirical research and validate the research hypothesis. [Result/conclusion] Research results are consistent with the hypothesis in that ① the community organization mechanisms have significant positive effects on the community social network structure; ② the community technical mechanisms have significant positive influences on the community social network structure; ③ the community social network structure positively influences corporate knowledge acquisition; ④ the community social network structure positively influences the enterprise knowledge transformation; ⑤ the community social network structure positively influences the activity of the community innovation source; ⑥ the activity of the community innovation source positively affects the scale of the community innovation source; ⑦ the scale of the community innovation source positively influences the enterprise knowledge transformation; ⑧ the enterprise knowledge transformation positively affects the enterprise innovation performance; ⑨ the activity of the community innovation source positively affects the enterprise innovation performance. Consequently, the strategic guidance for the construction and development of open innovation communities is provided.
Subjects: Library Science，Information Science >> Library Science submitted time 2023-10-08 Cooperative journals: 《知识管理论坛》
Abstract： [Purpose/significance] Online health community has been developing rapidly, but it is difficult to reveal the inherent mechanism between network node attribute and user dynamic interaction mode, with the lack of research on node attribute-based dynamic networks. [Method/process] This paper constructed the research model for users temporal interactive mode of online health community by applying NATERGM （Node Attribute-based Temporal Exponential Random Graph Model）, taking the online health community as research object, and combining with the feature of the user node properties that including users emotional tendency, the post text and the user community level. Then, data from Baidu Diabetes community from October 2016 to February 2018, which involves 2301 users, 6045 posts and 9490 replies, was used for empirical research. [Results/conclusion] Results indicate that the validity of NATERGM in analyzing temporal interactive mode, and node attributes have significant effects on reciprocity temporal mode, k-star temporal mode, transitivity temporal mode and cyclicity temporal mode. Consequently, suggestions for the development of online healthy community construction are put forward.
Subjects: Psychology >> Social Psychology submitted time 2023-03-27 Cooperative journals: 《心理学报》
Abstract： Insufficient behavior control in patients with attention deficit / hyperactivity disorder (ADHD) is closely related to decision impulsivity, which is regulated by medial prefrontal cortex (mPFC) and nucleus accumbens (NAc). In ADHD patients, the mPFC and NAc show abnormality both structurally and functionally, indicating that these two brain regions are involved in regulation of decision-making, especially impulsivity. Although extensive anatomical connections between mPFC and NAc have been found, the role of mPFC-NAc circuit in decision impulsivity remains to be investigated. Wistar (WIS) rats and ADHD rats (SHR, spontaneously hypertensive rat) were used as subjects of this study. We recorded the local field potential (LFP) of mPFC and NAc using multi-channel electrophysiology during a delay discounting task (DDT). We further analyzed the coherence difference of Theta (4~12 Hz) oscillation in expectation period (0~3s) and compared this measure between the two groups. Results: (1) SHR rats had higher decision impulsivity level than WIS group. Power spectral density between 6~12 Hz of LFP in mPFC and NAc increased in both groups. (2) When choosing large/delayed rewards, coherence of mPFC-NAc activity increased compared to small/immediate rewards in WIS group. This indicates that the mPFC-NAc circuit mediates decision impulsivity. (3) When choosing large/delayed rewards, mPFC-NAc activity in SHR group showed lower coherence than WIS group, indicating SHR rats have weaker mPFC-NAc functional connections. (4) Coherence of mPFC-NAc activity is higher during initial choice behavioral than continuous choice behavior. It indicated that stronger mPFC-NAc functional connections are required during controlled information processing (dominant in initial choice behavioral), rather than automatic information processing (dominant in continuous choice behavior). Coherence of mPFC-NAc activity is higher in WIS group than SHR group when choosing large/immediate rewards. It indicated that the decision impulsivity deficits in SHR rats results from mPFC-NAc weak functional connections. (5) Coherence of mPFC-NAc activity is higher in shift trials than continuous trials. Plus, WIS group showed an overall higher coherence than SHR group. This indicated that mPFC-NAc circuit heavily involves in controlled information processing, and SHR group has deficiency of this process. (6) Regression analysis showed that coherence difference of mPFC-NAc activity in prediction period has positive correlation with delayed large reward selection rate in WIS group, that is, the more coherence of mPFC-NAc Theta activity increased during prediction period, the less decision impulsivity WIS rats behaved during choice period. However, the coherence difference cannot predict decision impulsivity in SHR group.Conclusion: mPFC-NAc heavily involves in decision impulsivity. Increase of coherence of mPFC-NAc theta oscillation in prediction period can predict impulsivity level. The study revealed that weak mPFC-NAc functional connections mediate decision impulsivity in ADHD and brought new perspectives in the treatment of ADHD.
Subjects: Materials Science >> Materials Science (General) submitted time 2023-03-19 Cooperative journals: 《金属学报》
Abstract： Rigid restraint thermal self-compressing bonding is a new solid-state bonding process. During the process, localized non-melted heating method is employed to heat the butted interface of the rigid restrained plates to be bonded. Under the localized heating, materials close to the butted interface are expanded. However, due to the existence of surrounding cool metals and rigid restraints, the expansion of the high temperature materials is restrained and thus, a compressive pressure is developed which compresses the high temperature metals near the bond interface and facilitates the atom diffusion between butt-weld specimens to produce a permanent solid-state joint. Utilizing the localized stress-strain field to accomplish atomic bonding, this process can avoid the use of external forces on which diffusion bonding and other solid-state bonding methods rely. Previous study has proven the feasibility of this process to join titanium alloys. In present work, the effect of beam power on bond interface, microstructure and mechanical properties of the TC4 joints bonded at different beam powers were analyzed through the OM observation, EBSD analysis, mechanical property test and fracture morphology analysis. Meanwhile, in order to reveal the mechanism about the effect of beam power on bond interface, the experiment study on microstructure and mechanical property and finite element analysis on present bonding were conducted to investigate the effect of beam power on the thermal stress-strain process during bonding. The results show that with the increase of beam power, the heating temperature, dwell time over high temperature, volume of materials with high temperature and the compressive plastic strain increase which promote the atom diffusion and thus bond quality of the interface is improved. At low beam power, the microstructure of the joints is homogeneous, while coarse grain with acicular a phase forms in the joint when the beam power is high. Mechanical properties of the joint are dependent on bond rate and microstructure. When the beam power is lower or higher, the compressive mechanical properties of the joints are poor because of the poor bonding quality of the interface or the coarse microstructure developed in the joint. Good comprehensive mechanical properties are obtained at the beam power of 330W.
Subjects: Psychology >> Physiological Psychology submitted time 2022-09-29
Abstract： Insufficient behavior control in patients with attention deficit / hyperactivity disorder (ADHD) is closely related to decision impulsivity, which is regulated by medial prefrontal cortex (mPFC) and nucleus accumbens (NAc). mPFC and NAc is involved in the regulation of decision-making process and impulsivity, and the structure and function of mPFC and NAc are abnormal in ADHD. The relationship between the functional coupling of mPFC-NAc circuit and abnormal decision impulsivity in ADHD is still under debate, abnormality of this circuit may provide explanations to the neural mechanism underlying ADHD. Wistar (WIS) rats and ADHD rats (SHR, spontaneously hypertensive rat) were used as subjects of this study. We recorded the local field potential (LFP) of mPFC and NAc using multi-channel electrophysiology during a delay discounting task (DDT). We further analyzed the coherence difference of Theta (4~12Hz) oscillation in expectation period (0~3s) and compared this measure between the two groups. Results: (1) SHR rats had higher decision impulsivity level than WIS group. Power spectral density between 7~9Hz of LFP in mPFC and NAc increased in both groups. (2) When choosing large/delayed rewards, coherence of mPFC-NAc activity increased compared to small/immediate rewards in WIS group. This indicates the mPFC-NAc circuit involves in decision impulsivity. (3) When choosing large/delayed rewards, mPFC-NAc activity in SHR group showed lower coherence than WIS group, indicating SHR rats have weaker mPFC-NAc functional connections. (4) Coherence of mPFC-NAc activity is higher during initial choice behavioral than continuous choice behavior. It indicated that stronger mPFC-NAc functional connections are required during controlled information processing which is dominant in initial choice behavioral, while automatic processing is dominant in continuous choice behavior. Coherence of mPFC-NAc activity is higher in WIS group than WIS group when choosing large/immediate rewards. It indicated that the decision impulsivity deficits in SHR rats results from mPFC-NAc weak functional connections. (5) Coherence of mPFC-NAc activity is higher in shift trials than continuous trials. Plus, WIS group showed an overall higher coherence than SHR group. This indicated that mPFC-NAc circuit heavily involves in controlled information processing, and SHR group has deficiency of this process. (6) Regression analysis showed that coherence difference of mPFC-NAc activity in prediction period has positive correlation with delayed large reward selection rate in WIS group, that is, the more coherence of mPFC-NAc Theta activity increased during prediction period, the less decision impulsivity WIS rats behaved during choice period. However, the coherence difference cannot predict decision impulsivity in SHR group. Conclusion: mPFC-NAc heavily involves in decision impulsivity. Increase of coherence of mPFC-NAc theta oscillation in prediction period can predict impulsivity level. Decision impulsivity in ADHD as a consequence of the dysfunction, is caused by a weak mPFC-NAc functional connection.
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