Subjects: Medicine, Pharmacy >> Preclinical Medicine submitted time 2018-01-25 Cooperative journals: 《南方医科大学学报》
Abstract： Extracellular vesicles (EVs) are small vesicles released by cells, which contain proteins and miRNA. It is a new research field in recent years. EVs change accordingly in a variety of diseases. These vesicles can sensitively reflect the pathological changes of the body. Compared with tissue biopsy, EVs detection have the advantages of non-invasive, simple sampling and real-time monitoring. EVs are becoming new diagnostic marker. This article reviews the current status and progressofEVsinclinicalapplication.
Subjects: Medicine, Pharmacy >> Preclinical Medicine submitted time 2017-12-07 Cooperative journals: 《分子影像学杂志》
Abstract：医学影像学是一门理论性和实践性都很强的学科，涉及范围广。医学影像专业医学生真正进入临床成为合格的影像医师必需经过科学的、具有实效的临床教学阶段。迷你临床评估演练(Mini-CEX)作为一种重要的、先进的临床教学方法已初步应用于临床内科、外科、口腔及护理等临床科室以评价各类医学生的实训操作能力，并收到了较好的效果。而目前国内大陆地区尚未见Mini-CEX应用于医学影像学科中的研究和报道。Mini-CEX应用于医学影像专业的临床教学评估，有助于培养学生形成正确的影像思维，促进医学与人文的融合,促进医患关系的和谐，提高自主分析问题、解决问题的能力，提高临床教学水平。该方法在影像学科初步取得了良好的临床教学效果。
Subjects: Medicine, Pharmacy >> Preventive Medicine and Hygienics submitted time 2023-11-01 Cooperative journals: 《中国全科医学》
Abstract： With the wide application of artificial intelligence（AI）in the medical field，more and more AI#2;based clinical decision support systems have been applied in the clinical diagnosis，screening，and other fields. Early clinical evaluation is important for evaluating the clinical performance，safety，and human factors of AI-based clinical decision support systems，and laying the foundation for large-scale trials. However，the transparency and integrity of the clinical reports need to be improved. The Developmental and Exploratory Clinical Investigations of Decision support systems driven by Artificial Intelligence（DECIDE-AI）was officially published online in May 2022. Based on this guideline and relative literature，this paper explores the transparent reporting of early-stage clinical evaluation of AI-based decision support systems，in order to help developers and researchers of AI-based clinical decision support system better understand and apply the relevant guidelines，and improve the reporting transparency of early clinical evaluation of AI-based clinical decision support systems.
Subjects: Medicine, Pharmacy >> Clinical Medicine submitted time 2023-01-09 Cooperative journals: 《中国全科医学》
WANG Qiu-qin
Zhang Yu-tong
Xu Yu-chen
Bai Ya-mei
CHEN Hua
JIANG Rong-rong
YAN Shu-xia
WANG Qing
XU Gui-hua
Xie Ying
Qiao Chun
Yang Juan
Abstract：
Background Gua Sha is one of the most widely used traditional Chinese medicine (TCM) non-drug therapies, which is safe, effective and easy to promote and has unique advantages in the treatment of nervous system diseases. Parkinson's disease (PD), one of the most common neurodegenerative diseases, has become a global medical problem due to the obvious side effects of drug treatment and the reduced efficacy of long-term use. Objective To explore the clinical effect of Gua Sha on PD. Methods 32 patients with primary PD in the early and middle stages were selected by purposive sampling from March 2021 to September 2021 in an outpatient clinic of Nanjing Hospital of Chinese medicine and Jiangsu Province Hospital, and were divided into observation group (16 cases) and control group (16 cases). The observation group was treated with Gua Sha combined with oral western medicine, while the control group was treated with oral western medicine alone. After 3 months of treatment and 1 month of follow-up, the scores of the third part of the unified Parkinson's disease rating scale (MDS-UPDRS Ⅲ), the non motor symptom score (NMSS) and the overall efficacy were observed. The contents of serum interleukin IL-1β and NF- κB were observed after 3 months of treatment, and the difference between the two groups was compared. Results After 3 months of treatment, the scores of MDS-UPDRS Ⅲ and NMSS in both groups were lower than those before treatment (all P<0.0001), and the scores in the observation group were lower than those in the control group (all P<0.01); The contents of serum IL-1β and NF- κB of two groups were lower than that before treatment (all P<0.05), and the contents of the observation group were lower than that in the control group (all P<0.05); The total effective rate in the observation group was 87.50% (12 of the 14 effective cases were effective and clinically controlled, accounting for 85.71%), and the total effective rate of the control group was 62.50% (0 of the 10 effective cases were effective and clinically controlled). The difference of the curative effect between the two groups was statistically significant (P<0.001). After 1-month follow-up, the scores of MDS-UPDRS Ⅲ and NMSS in both groups were lower than those before treatment (all P<0.0001), and those in the observation group were lower than the control group (all P<0.05); The total effective rate of the two groups was 87.50%. 12 cases of the 14 effective cases in the observation group were significantly effective and clinically controlled, accounting for 85.71%. The number of markedly effective and clinically controlled cases in the control group was 0. The difference between the two groups was statistically significant (P<0.01). Compared with 3 months of treatment, the MDS-UPDRS Ⅲ score of the control group decreased at 1-month follow-up (P<0.05), while the score change in the observation group was not statistically significant (P>0.05); The NMSS score of the patients in the observation group increased (P<0.05), but there was no significant difference in the change of the score in the control group (P>0.05). Conclusions Gua Sha is safe and feasible for the treatment of primary PD in the early and middle stages, which can improve some motor dysfunction of PD patients, reduce non motor symptoms, and significantly improve the clinical efficacy. Its long-term efficacy needs to be further explored by large sample and multi center research.
Subjects: Medicine, Pharmacy >> Preclinical Medicine submitted time 2022-09-30 Cooperative journals: 《中国全科医学》
Abstract： Takayasu arteritis is a chronic granulomatous vasculitis that primarily affects the aorta and its major branches, resulting in vascular stenosis, occlusion, and aneurysm development. It has a particularly negative effect on women of reproductive age. Although most studies suggest that Takayasu arteritis is stable throughout pregnancy, it may still cause maternal difficulties such as hypertension, preeclampsia, premature birth, and fetal growth limitation. Controlling disease activity during peri-pregnancy is critical for reducing the negative consequences of Takayasu arteritis on pregnant women and babies. This article summarizes relevant research on the clinical treatment of Takayasu arteritis during pregnancy to give practical guidelines.
Subjects: Nursing >> Nursing submitted time 2023-09-26
Abstract： In 1987, the United States proposed to use the concept of "geriatric nursing" to replace the concept of "geriatric nursing", because the geriatric nursing involves a wider range of nursing. This includes assessing the health and functional status of older persons, developing care plans, providing effective nursing and other health care services, and evaluating care outcomes. The teaching effect of geriatric nursing is directly related to the degree of nursing interns' knowledge mastery of this course. In RECENT YEARS, WITH THE continuous reform and innovation of GERiatric nursing teaching, new teaching methods are more and more applied. This article reviews the reform and innovation of teaching methods of "geriatric nursing".
Peer Review Status:
Awaiting Review
Subjects: Medicine, Pharmacy >> Preclinical Medicine submitted time 2017-12-07 Cooperative journals: 《分子影像学杂志》
Abstract： Objective To investigate the significance of the minimally invasive treatment of armpit deputy breast after clinical typed. Methods Separate 68 cases (116 sides) of axillaty accessory breast into 3 types by 2 factors: (1) fat/gland ratio (2)the relative position of gland. Different type select different surgical minimally invasive treatment, observed surgery and clinical effects. Results There are significant statistical significance between each clinical group in operative time, and no statistical significance in the amount of bleeding, drainage and so on. All cases were primary healing, hidden and tiny scar. Conclusion The operative time get shorten in different minimally invasive surgical procedure after clinical classification. It achieves a minimally invasive and aesthetic effect which is worthy of clinical application.
Subjects: Medicine, Pharmacy >> Clinical Medicine submitted time 2018-12-12 Cooperative journals: 《协和医学杂志》
Abstract：胰腺导管腺癌( pancreatic ductal carcinoma, PDAC)是一种极为凶险、高度恶性的消化道肿瘤，其诊治路径中的常见问题主要包括:(l)筛查和早期检出;}2)准确诊断分期;(3)鉴别诊断;}4)随访及治疗评估，影像学在其中均扮演重要角色。本文总结各种影像学检查在PDAC诊治路径中的作用及价值，深人了解各种影像学检查的优势和局限性，提供基于证据的PDAC影像学检查流程，并重点阐述PDAC影像诊断与鉴别诊断要点，从而更好地指导临床决策，改善PDAC患者预后。
Subjects: Medicine, Pharmacy >> Preclinical Medicine submitted time 2017-12-07 Cooperative journals: 《分子影像学杂志》
Abstract： Objective To research the rational use of medicine to treat hypertension, based on the role of fruits and vegetables in therapy. Methods 220 cases of patients diagnosed with hypertension were randomly divided into two groups. The control group and the treatment group. The control group received conventional western medicine treatment, the treatment group were given both the conventional treatment and a reasonable dietary guidance of how to make rational use of fruits and vegetables. Comparing the clinical effects of patients in two groups. Results The total effective rate was 91.82% in the control group, at the same time, the other group was 82.73%, There is a significant difference(丫=4.09, P<0.05). Comparing the effective rates of two groups by using } test, and making P<0.05 both two groups, the effect of treatment group is better than the other, after give the different guidance. During Two groups showed no significant adverse reactions. Conclusion The therapeutic schedule of making rational use of fruits and vegetables beside using conventional treatment is worth of further study and promoting, on account of it is high efficacy，affordable, no side effects further.
Subjects: Medicine, Pharmacy >> Clinical Medicine Subjects: Statistics >> Biomedical Statistics submitted time 2022-11-21
Abstract： Sample size determination for clinical trials is one of the key components of study design. Based on medical device registration review recently published by National Medical Products Administration, Center for Medical Device Evaluation, and other public information, we conducted an analysis of the sample size for medical device registration clinical trials, including study design, part of which being compared with that in the US. Our results showed that the median sample size for Class III medical device registration trials is 120 (IQR 90~167.5). Sample size was influenced significantly by regulation policies, and some differed significantly from that in the US. Disclose of registration review is a giant leap for medical device regulation in China; however, the disclosed information needs to be further improved.
Peer Review Status:Awaiting Review
Subjects: Nursing >> Nursing submitted time 2023-10-14
Abstract：目的 ：探讨中药膏摩联合中药封包技术对下肢丹毒患者的治疗效果 ，旨在进一步促进患者康复并为临床提供参考。方法 针对下肢丹毒患者的主要临床症状，为患者实施中药膏摩联合中药封包技术，比较患者临床症状的改善情况。结论 中药膏摩联合中药封包技术改善了下肢丹毒患者的红、肿、热、痛症状，促进了患者康复及提高了对护理工作的满意度 ，值得在临床上推广。
Peer Review Status:Awaiting Review
Subjects: Medicine, Pharmacy >> Clinical Medicine submitted time 2022-08-17 Cooperative journals: 《中国全科医学》
Abstract： Patient-reported outcomes (PROs) can provide strong evidence for medical decision making, health policy development, and also serve as a benchmark for monitoring symptoms when provide timely and personalized medical care to participants. With the widespread applications of PROs in clinical research, ethical issues have received deeply attention. This guideline was established to develop an international, consensus-based reference for clinical research that focuses on the ethical considerations of PROs. Addressing ethical issues in PROs can improve the quality of PROs data while minimizing the risk, burden, and harm to patients and protecting the rights of participants and investigators in clinical research.
Subjects: Biology >> Bioengineering submitted time 2018-11-05 Cooperative journals: 《中国生物工程杂志》
Abstract：单克隆抗体药物以其独特的作用机制及高效性，在恶性肿瘤和自身免疫疾病的治疗中发挥了不可估量的重要作用，成为全球的研发热点。基于科睿唯安旗下的Cortellis数据库，采用定量分析和专家智慧相结合的方法，从总体研发和商业化现状、主要国家/地区、技术和种类、靶点及作用机制、市场份额、产品交易多个维度展现出全球单克隆抗体药物的研发和商业化全景。分析结果显示：全球已上市的单克隆抗体药物有133个，其中已上市的人源化单克隆抗体药物占已上市的单克隆抗体药物总数的37.6%。作用靶点主要集中在HER、TNF、CD20、PD-1/L1、VEGF以及CD3，其中作为HER2酪氨酸激酶受体抑制剂的药物数量最多。美国在单克隆抗体药物研发和商业化方面遥遥领先，中国在研和上市的单抗隆抗体药物总数排名第二，但中国上市的单抗隆抗体药物数量仅8个。2017年销售额高于10亿美元的单克隆抗体药物有22个。全球单克隆抗体药物的交易数量共有1408次，药物开发与商业化许可是最主要的交易方式。未来，单克隆抗体药物的发展趋势将朝着新靶点、新适应症和新用药方案的方向发展，将会产生更多“重磅炸弹药物”。
Subjects: Biology >> Bioengineering submitted time 2018-08-13 Cooperative journals: 《中国生物工程杂志》
Abstract：目的：从产品开发角度分析PD-1/PD-L1单抗的发展现状和未来趋势。方法：检索科睿唯安（Clarivate Analytics）的Cortellis数据库的数据，利用定量分析法和对比分析法对检索结果进行分析。结果：目前已有5种PD-1/PD-L1单抗上市，4种PD-1/PD-L1单抗处于预注册及6种处于临床Ⅲ期，未来市场上的PD-1/PD-L1单抗将呈现快速增长趋势。此外，PD-1/PD-L1单抗的商业交易也越来越多，目前共发生包括药物开发及商业化许可、专利资产出售以及早期药物研发合作等10余起交易，其中药物开发及商业化许可是最主要的交易模式。结论：虽然PD-1/PD-L1单抗市场尚处于起步阶段，但随着未来技术的不断发展改进，相信未来有更多的PD-1/PD-L1单抗上市，为癌症及其他疾病的治疗提供新的契机。
Subjects: Medicine, Pharmacy >> Preclinical Medicine submitted time 2017-12-07 Cooperative journals: 《分子影像学杂志》
Abstract： Chinese special national conditions and the health needs of the people at present stage made sickbeds increaserapidly. Pathologists had a huge gap. Many medical colleges or universities set clinical pathology for the undergraduate ormaster’ students in line with medical market and heath needs. But these college were lack of appropriate facilities and trainingbase . The students after graduation could not be well adapted to clinical work. Pathology training base was the mostimportant place to performed pathology practice teaching and training for students’ practical skills. According to the needs ofclinical pathology specialty and other specialties course, Southern Medical University unified the university, enterprise andhospital to build a pathology training that covering teaching, research and practice or service which called integrated school-hospital-enterprise pathology training base.
Subjects: Medicine, Pharmacy >> Preclinical Medicine submitted time 2017-12-07 Cooperative journals: 《分子影像学杂志》
Abstract：目的 探讨急诊危重患者院内转运采用优质护理的效果。方法 我院从2015年4月起在广泛开展优质护理服务，在活动前后半年间随机抽样调查急诊危重转运的患者各180例，采用问卷调查及现场考核等方法，综合评价活动前后护理质量、护理不良事件、转运时长、护理工作满意度等效果。结果 观察组护理质量以及患者对护理工作满意度明显提高，护理不良事件发生率、转运时长均低于对照组，差异有统计学意义（P<0.05)。结论 将优质护理相关措施应用在急诊危重患者院内转运护理过程中，降低护理不良事件发生率，提高转运速度，同时也提高患者和接收科室满意度。
Subjects: Nursing >> Nursing submitted time 2023-09-11
Abstract： Abstract: With the change of modern medical models, clinical nursing pathways have been widely applied in clinical nursing work. Through the application of clinical nursing pathways, not only can patients receive good treatment results, but also improve patient satisfaction, which is of great significance for patient recovery. Applying clinical nursing pathways in obstetrics and gynecology can not only improve the treatment effectiveness of patients, but also enhance their satisfaction with the hospital. Based on this, this article first analyzes the importance of applying clinical nursing pathways in obstetrics and gynecology, and proposes specific measures for the application of clinical nursing pathways in obstetrics and gynecology.
Peer Review Status:Awaiting Review
Subjects: Medicine, Pharmacy >> Clinical Medicine submitted time 2022-10-17 Cooperative journals: 《中国全科医学》
Abstract： The key to train high qualified general practitioners is to improve their professionalcompetence, and the training of general clinical reasoning is one of the ways to improve it. The Department of general practice of Tongji University has designed and developed the course of general practice clinical reasoning for general practice residents, active general practitioners (GPs) and specialists with intention to be GPs. The combination of theory and practice to join the general practitioner team, coordinated service, continuous service and other elements that reflect the characteristics of GPs` competency can help trainees to cultivate their clinical reasoning on diagnosis and treatment, so as to improve their job competency.
Subjects: Biology >> Bioengineering submitted time 2018-01-15 Cooperative journals: 《中国生物工程杂志》
Abstract：目的：从产品开发角度分析寡核苷酸类药物的发展现状和未来趋势。方法：检索科睿唯安（Clarivate Analytics）的Cortellis数据库的数据，利用定量分析法和对比分析法对检索结果进行分析。结果：目前已有7种寡核苷酸类药物上市，4种寡核苷酸类药物处于预注册及16种处于临床Ⅲ期，未来市场上的寡核苷酸类药物将呈现快速增长趋势。此外，寡核苷酸类药物的商业交易也越来越多，目前共发生包括药物开发及商业化许可、专利资产出售以及早期药物研发合作等10余起交易，其中药物开发及商业化许可是最主要的交易模式。结论：虽然寡核苷酸类药物市场尚处于起步阶段，但随着未来技术的不断发展改进，相信未来有更多的寡核苷酸类药物上市，为癌症及其他疾病的治疗提供新的契机。
Subjects: Medicine, Pharmacy >> Preclinical Medicine submitted time 2017-12-27 Cooperative journals: 《南方医科大学学报》
Abstract： Objective To investigate the function of AT motif binding factor 1 (ATBF1) in colorectal cancer. Methods ATBF1 protein expression was detected in 146 pairs of colorectal cancer tissues and the adjacent tissues using immunohistochemistry. ATBF1 protein expression was also examined in colorectal cell lines with laser confocal microscopy. ATBF1-A protein expression in colorectal cancer tissues of different differentiation grades and in the colorectal cancer cell lines were detected with estern blotting. The expressions of ATBF1 mRNA in 38 moderately differentiated colorectal cancer tissues and the paired adjacent tissues and in the colorectal cancer cell lines were tested using RT-PCR. Results ATBF1 protein expression levels in colorectal cancer tissues and adjacent tissues differed significantly (P<0.001), and its expression increased significantly in positive correlation with the grade of tumor differentiation (P<0.001) but in negative correlation with tumor metastasis. ATBF1 mRNA expression and ATBF1 protein expression were significantly correlated (P=0.100). The ATBF1 protein and mRNA expressions also differed significantly among different colorectal cancer cell lines. Conclusion ATBF1 executes the role of a tumor suppressor gene in colorectal cancer, and its protein expression is associated with tumor differentiation and lymph node metastases.
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