Subjects: Psychology >> Social Psychology submitted time 2019-12-19
Abstract： "
Peer Review Status:
Awaiting Review
Subjects: Medicine, Pharmacy >> Clinical Medicine submitted time 2023-08-11 Cooperative journals: 《中国全科医学》
Abstract： Background The elderly tend to coexist with multiple chronic diseases（such as diabetes and hypertension），while diabetes and hypertension can lead to chronic kidney damage，and fewer studies have been conducted on chronic kidney disease in older adults. Objective To investigate the proteinuria and renal dysfunction in the elderly population and provide guidance for the management of chronic kidney disease in the community-dwelling older adults by collecting the clinical data of physical examination of the elderly residents in zhuanqiao community. Methods A total of 13 080 elderly residents who underwent physical examination in Zhuanqiao Community Health Service Center of Minhang District from 2020 to 2021 were included as the study objects. General information，physical examination results and laboratory examination data of patients were collected. Subjects with eGFR<60 mL·min-1·（1.73 m2 ）-1 were included in the abnormal renal function group （n=713），and subjects with estimated glomerular filtration rate（eGFR）≥ 60 mL·min-1·（1.73 m2 ）-1 were included in the normal renal function group（n=12 367）. The subjects with positive urine protein were included in the proteinuria group（n=1 690），and the subjects with negative urine protein were included in the non-proteinuria group（n=11 390）. At the same time， the subjects were divided into 60 to 69 years old group（n=6 901），70 to 79 years old group（n=4 867），80 to 89 years old group（n=1 128）and ≥ 90 years old group（n=184）according to the age interval of 10 years. Multivariate logistic regression analysis was used to explore the influencing factors of renal dysfunction in the study population. Results There were significant differences in the detection rates of urine protein positive and renal dysfunction in 60 to 69 years old，70 to 79 years old，80 to 89 years old and ≥ 90 years old groups（P<0.05）. The detection rate of urinary protein positive in males aged 60 to 69 years and 70 to 79 years was higher than that in females，the detection rate of renal dysfunction in males aged 60 to 69 years was higher than females，and the detection rate of renal dysfunction in males aged 80 to 89 years was lower than females，the difference was statistically significant（P<0.05）. Age，the proportion of diabetes and hypertension，blood urea nitrogen（BUN），blood creatinine（Scr）and triglyceride（TG）in the abnormal renal function group were higher than those in the normal renal function group，while total cholesterol（TC），high density lipoprotein cholesterol（HDL-C），low density lipoprotein cholesterol（LDL-C）and hemoglobin（Hb）in the abnormal renal function group were lower than those in the normal renal function group. There was significant difference in urinary albumin/creatinine ratio（ACR）between the two groups（P<0.05）. Multivariate logistic regression analysis showed that age，hypertension，diabetes，proteinuria and anemia were the influencing factors of renal dysfunction（P<0.05），while male，diabetes，obesity，hypertriglyceridemia，Scr and BNU were the influencing factors of proteinuria（P<0.05）. Conclusion The detection rates of proteinuria and renal dysfunction in the elderly aged 60 years and above are high，which increase with age. Age，hypertension，diabetes，anemia，hypertriglyceridemia and low HDL-C level are risk factors for renal dysfunction（P<0.05）；male，diabetes，obesity，hypertriglyceridemia，Scr and BUN are risk factors for proteinuria.
Subjects: Physics >> General Physics: Statistical and Quantum Mechanics, Quantum Information, etc. submitted time 2018-01-05 Cooperative journals: 《工程热物理学报》
Abstract：本文采用分子动力学模拟方法研究离子的存在对水蒸气核化过程的影响。模拟系综初始温度为600 K，达到平衡后撤去水蒸气热浴，将载气温度标定至200 K，与水蒸气进行热量交换，带走水蒸气核化释放的核化潜热。研究结果表明，离子的存在能够促使核化的发生，但离子的浓度对系综内最大团簇的生长影响较小。根据团簇分析统计系综内含20 个Na+/Cl-时，核化率约为1.011028/(cm3s)，与经典核化理论计算值4.89×1028/(cm3s)在同一个数量级。
Subjects: Dynamic and Electric Engineering >> Engineering Thermophysics submitted time 2017-11-07 Cooperative journals: 《工程热物理学报》
Abstract： Molecular dynamics simulation was employed to explore the mechanism of heterogeneous nucleation of water vapor under the effect of ions. After the system reached to the equilibrium state at initial temperature 600 K, the temperature of carrier gas was rescale at 200 K, which worked as the heat resource for the water vapor nucleation. The nucleation heat was removed by carrier gases during the nucleation process. The results show that, ions promote the nucleation progress on the initial stage, and the concentration of ions has less effect on the growth of the largest cluster in the system. The nucleation rate obtained from the cluster analysis was 1.01�028/(cm3譻) in the system with 20 Na+ and 20 Cl- ions, which is in the same order of magnitude with the value 4.89�028/(cm3譻) predicted by classic nucleation theory analysis.
Hits
Hits
Downloads
Comment