Subjects: Medicine, Pharmacy >> Clinical Medicine submitted time 2024-04-09 Cooperative journals: 《中国全科医学》
Abstract： Severe acute respiratory syndrome coronavirus 2（SARS-CoV-2）infection is a major public health emergency in the world in the past century，which poses a major threat to the global health system. After rehabilitation from SARS-CoV-2 infection，some patients may experience multiple respiratory symptoms for a long time，which is called the acute sequelae of SARS-CoV-2 infection. Post-COVID-19 pulmonary fibrosis（PCPF）as one of them，can affect the respiratory function and quality of life of patients to varying degrees. Regarding the treatment of PCPF is a hot topic in current research，and this article provides a review of treatment methods for PCPF，aiming to improve the prognosis of PCPF patients.
Subjects: Medicine, Pharmacy >> Preventive Medicine and Hygienics submitted time 2024-01-24 Cooperative journals: 《中国全科医学》
Abstract： Background Patients with ST-segment elevation myocardial infarction（STEMI）undergoing percutaneous coronary intervention（PCI）face a significant risk of long-term major adverse cardiovascular events（MACEs）. Accurate early risk stratification is crucial for managing post-PCI MACEs in STEMI patients，as highlighted in clinical guidelines. Existing risk scoring systems，including the Age，Creatinine，and Ejection Fraction（ACEF）score，Thrombolysis in Myocardial Infarction（TIMI）score，Zwolle score，Primary Angioplasty in Myocardial Infarction（PAMI）score，and Controlled Abciximab and Device Investigation to Lower Late Angioplasty Complications（CADILLAC）score，vary in their predictive utility for the long-term prognosis post-PCI in STEMI patients. Objective This study aims to analyze the risk factors for long-term MACEs post-PCI in STEMI patients in China and compare the predictive value of the commonly used ACEF，TIMI，Zwolle，PAMI，and CADILLAC risk scoring systems. Methods A retrospective cohort of 687 STEMI patients who underwent their first PCI between June 2016 and June 2020 at Gansu Provincial People's Hospital was selected. Patient demographics，laboratory，and imaging results were collected，and risk scores were assigned using the ACEF，TIMI，Zwolle，PAMI，and CADILLAC systems. Patients were followed up annually via phone or clinic visits until August 2023，with a focus on the occurrence of MACEs. Multivariable logistic regression analysis was used to explore the factors influencing the occurrence of MACEs post-PCI. Receiver Operating Characteristic（ROC）curves for the different risk scoring systems were plotted，and their areas under the curve（AUC）were compared using the DeLong test. Results Out of the 687 patients who underwent PCI，44 were excluded due to incomplete data，leaving 643 for analysis. The median follow-up period was 37（range 25-49）months. By the end of the follow-up，134 patients had experienced MACEs，representing a 20.8% incidence rate. The MACEs group differed significantly from the non-MACEs group in terms of age，hospital stay duration，Killip class，N-terminal pro b-type natriuretic peptide，fibrinogen，anemia，left ventricular ejection fraction，estimated glomerular filtration rate，and creatinine levels（P<0.05）. Multivariable logistic regression revealed prolonged hospital stay（OR=1.071，95%CI=1.012-1.134，P=0.018），elevated creatinine（OR=1.018，95%CI=1.006-1.030，P=0.003），and increased fibrinogen（OR=1.226，95%CI=1.066-1.409，P=0.004）as risk factors for MACEs，while higher left ventricular ejection fraction（OR=0.980，95%CI=0.960-1.000，P=0.045），mild（OR=0.377，95%CI=0.051-0.938，P=0.036），and moderate regurgitation（OR=0.164，95%CI=0.051-0.522，P=0.002）were protective. The ACEF，TIMI，Zwolle，PAMI，and CADILLAC scores were significantly higher in the MACEs group（P<0.05）. The ROC curves for predicting MACEs post-PCI in STEMI patients showed no significant differences among the five risk scoring systems（P>0.05）. Conclusion Hospital stay duration，creatinine levels，fibrinogen，left ventricular ejection fraction，and valvular regurgitation status are significant factors affecting the occurrence of long-term MACEs post-PCI in STEMI patients. While all five risk scoring systems—ACEF，TIMI，Zwolle，PAMI，and CADILLAC—can predict the occurrence of long-term MACEs in these patients，the CADILLAC score is recommended for its distinctiveness and sensitivity.
Subjects: Physics >> General Physics: Statistical and Quantum Mechanics, Quantum Information, etc. submitted time 2023-07-05 Cooperative journals: 《中国全科医学》
Abstract： As the number of obese and elderly population increases worldwide，sarcopenic obesity is becoming associated with a higher risk of adverse events and outcomes in multiple clinical situations，including cancer. However，there is a lack of unified definition and diagnostic criteria for sarcopenic obesity，and the interaction between sarcopenic obesity and cancer needs to be further clarified. This paper systematically and comprehensively summarizes the relevant definitions and diagnostic methods of sarcopenic obesity，discusses its clinical impact on cancer patients in detail，including the impact on patients undergoing surgery and chemotherapy，and briefly describes the main prevention and treatment strategies. This paper reviews literature and concludes that the incidence of sarcopenic obesity is high in cancer patients，but its definition and diagnostic criteria are still controversial. Sarcopenic obesity is an independent predictor of cancer prognosis with important clinical application value.
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