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1. chinaXiv:202003.00026 [pdf]

Effective Treatment of Severe COVID-19 Patients with Tocilizumab

Xu, Xiaoling; Han, Mingfeng; Li, Tiantian; Sun, Wei; Wang, Dongsheng; Fu, Binqing; Zhou, Yonggang; Zheng, Xiaohu; Yang, Yun; Li, Xiuyong; Zhang, Xiaohua; Pan, Aijun; Wei, Haiming
Subjects: Medicine, Pharmacy >> Clinical Medicine

Background: In December 2019, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was identified in Wuhan, China, which spread rapidly and has become a world-wide public health challenge. We aimed to assess the efficacy of tocilizumab in severe patients with Corona Virus Disease-19 (COVID-19) and seek a new therapeutic strategy. Methods: The patients diagnosed as severe or critical COVID-19 in The First Affiliated Hospital of University of Science and Technology of China (Anhui Provincial Hospital) and Anhui Fuyang Second People’s Hospital were given tocilizumab in addition to routine therapy between February 5 and February 14, 2020. The changes of clinical manifestations, CT scan image, and laboratory examinations were retrospectively analyzed. Findings: Within a few days, the fever returned to normal and all other symptoms improved remarkably. Fifteen of the 20 patients (75.0%) had lowered their oxygen intake and one patient need no oxygen therapy. CT scans manifested that the lung lesion opacity absorbed in 19 patients (90.5%). The percentage of lymphocytes in peripheral blood, which decreased in 85.0% patients (17/20) before treatment (mean, 15.52 ± 8.89%), returned to normal in 52.6% patients (10/19) on the fifth day after treatment. Abnormally elevated C-reactive protein decreased significantly in 84.2% patients (16/19). No obvious adverse reactions were observed. Nineteen patients (90.5%) have been discharged on average 13.5 days after the treatment with tocilizumab and the rest are recovering well. Interpretation: Tocilizumab is an effective treatment in severe patients of COVID-19, which provided a new therapeutic strategy for this fatal infectious disease.

submitted time 2020-03-05 Hits131301Downloads43796 Comment 0

2. chinaXiv:201708.00160 [pdf]

ac Josephson effect in the resonant tunneling through mesoscopic superconducting junctions

Yu Zhu, Qing-feng Sun, Wei Li, Zhong-shui Ma, Tsung-han Lin
Subjects: Physics >> The Physics of Elementary Particles and Fields

We investigate ac Josephson effect in the resonant tunneling through mesoscopic superconducting junctions. In the presence of microwave irradiation, we show that the trajectory of multiple Andreev reflections can be closed by emitting or absorbing photons. Consequently, photon-assisted Andreev states are formed and play the role of carrying supercurrent. On the Shapiro steps, dc component appears when the resonant level is near a series of positions with spacing of half of the microwave frequency. Analytical result is derived in the limit of infinite superconducting gap, based on which new features of ac Josephson effect are revealed.

submitted time 2017-08-05 Hits649Downloads302 Comment 0

3. chinaXiv:201609.01042 [pdf]

The cosmic ray test of MRPCs for the BESIII ETOF upgrade

Wang Xiao-Zhuang; Heng Yue-Kun; Wu Zhi; Li Cheng; Sun Yong-Jie; Dai Hong-Liang; Sun Sheng-Sen; Yang Rong-Xing; Cao Ping; Zhang Jie; Wang Yun; Sun Wei-Jia; Wang Si-Yu; Ji Xiao-Lu; Zhao Jin-Zhou; Gong Wen-Xuan; Ye Mei; Ma Xiao-Yan; Chen Ming-Ming; Xu Mei-hang
Subjects: Physics >> Nuclear Physics

In order to improve the particle identification capability of the Beijing Spectrometer III (BESIII),t is proposed to upgrade the current endcap time-of-flight (ETOF) detector with multi-gap resistive plate chamber (MRPC) technology. Aiming at extending ETOF overall time resolution better than 100ps, the whole system including MRPC detectors, new-designed Front End Electronics (FEE), CLOCK module, fast control boards and time to digital modules (TDIG), was built up and operated online 3 months under the cosmic ray. The main purposes of cosmic ray test are checking the detectors' construction quality, testing the joint operation of all instruments and guaranteeing the performance of the system. The results imply MRPC time resolution better than 100ps, efficiency is about 98%燼nd the noise rate of strip is lower than 1Hz/(scm2) at normal threshold range, the details are discussed and analyzed specifically in this paper. The test indicates that the whole ETOF system would work well and satisfy the requirements of upgrade.

submitted time 2016-09-14 Hits1028Downloads718 Comment 0

5. chinaXiv:201609.00002 [pdf]

The test of the electronics system for the BESIII ETOF upgrade

WANG Xiao-Zhuang; DAI Hong-Liang; WU Zhi; HENG Yue-Kun; Zhang Jie; CAO Ping; JI Xiao-Lu; Li Cheng; SUN Wei-Jia; WANG Si-Yu; WANG Yun
Subjects: Physics >> Nuclear Physics

It is proposed to upgrade the endcap time-of-flight (ETOF) of the Beijing Spectrometer III (BESIII) with multi-gap resistive plate chamber (MRPC), aiming at overall time resolution about 80 ps. After the entire electronics system is ready, some experiments, such as heat radiating, irradiation hardness and large-current beam tests,are carried out to certify the electronics' reliability and stability. The on-detector test of the electronics is also performed with the beam at BEPCII E3 line, the test results indicate that the electronics system fulfills its design requirements.

submitted time 2016-09-01 Hits1025Downloads511 Comment 0

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