Subjects: Nursing >> Nursing submitted time 2023-10-17
Abstract： This article summarizes the nursing experience of a patient with chronic pelvic inflammatory disease of dampness heat stasis type treated with traditional Chinese medicine packaging combined with traditional Chinese medicine enema. Through nursing evaluation, nursing measures such as traditional Chinese medicine characteristic nursing, pain nursing, emotional nursing, and dialectical nursing were implemented to improve the patient's clinical symptoms and quality of life, Summary and analysis: In the treatment of chronic pelvic inflammatory disease patients with dampness heat stasis type, the combination of traditional Chinese medicine packaging and traditional Chinese medicine enema has a significant effect, can improve the treatment efficiency, alleviate the relevant symptoms of patients, and has high treatment safety, which is worth promoting.
Peer Review Status:
Awaiting Review
Subjects: Nursing >> Nursing submitted time 2023-10-17
Abstract： This article aims to analyze the nursing experience of acupoint application therapy and ear acupoint seed embedding technology intervention in the treatment of one primiparous woman with postoperative uterine contractions and pain. Through nursing evaluation, traditional Chinese medicine characteristic nursing, pain nursing, emotional nursing, dialectical nursing and other nursing measures were implemented for the patient. The conclusion is that for primiparous women after delivery, on the basis of comprehensive rehabilitation nursing, traditional Chinese medicine acupoint application combined with ear acupoint seed embedding intervention can not only promote postoperative uterine involution, It can effectively alleviate postpartum uterine contractions without increasing the risk of complications, has high safety, and has certain clinical value.
Peer Review Status:Awaiting Review
Subjects: Nursing >> Nursing submitted time 2023-10-14
Abstract： This article aims to analyze the nursing experience of acupoint application therapy and ear acupoint seed embedding technology intervention in the treatment of one primiparous woman with postoperative uterine contractions and pain. Through nursing evaluation, traditional Chinese medicine characteristic nursing, pain nursing, emotional nursing, dialectical nursing and other nursing measures were implemented for the patient. The conclusion is that for primiparous women after delivery, on the basis of comprehensive rehabilitation nursing, traditional Chinese medicine acupoint application combined with ear acupoint seed embedding intervention can not only promote postoperative uterine involution, It can effectively alleviate postpartum uterine contractions without increasing the risk of complications, has high safety, and has certain clinical value.
Peer Review Status:Awaiting Review
Subjects: Nursing >> Nursing submitted time 2023-10-14
Abstract： This article summarizes the nursing experience of a patient with chronic pelvic inflammatory disease of dampness heat stasis type treated with traditional Chinese medicine packaging combined with traditional Chinese medicine enema. Through nursing evaluation, nursing measures such as traditional Chinese medicine characteristic nursing, pain nursing, emotional nursing, and dialectical nursing were implemented to improve the patient's clinical symptoms and quality of life, Summary and analysis: In the treatment of chronic pelvic inflammatory disease patients with dampness heat stasis type, the combination of traditional Chinese medicine packaging and traditional Chinese medicine enema has a significant effect, can improve the treatment efficiency, alleviate the relevant symptoms of patients, and has high treatment safety, which is worth promoting.
Peer Review Status:Awaiting Review
Subjects: Medicine, Pharmacy >> Preventive Medicine and Hygienics submitted time 2023-07-27 Cooperative journals: 《中国全科医学》
Abstract： Background Peripheral artery disease（PAD）is a common and serious cardiovascular disease，which is prone to complications of limb ischemia and adverse cardiovascular events. There is a gender difference in the prevalence of PAD，which has been relatively poorly studied. A full understanding of gender differences in prevalence of PAD in China is essential for public health policy development. Objective To analyze the gender differences in the prevalence of PAD in China and their causes，providing a theoretical basis for targeted screening and preventive measures. Methods The number of PAD cases，prevalence，age-standardized prevalence，attributable risk factors for disease burden，and corresponding 95% uncertainty intervals（UI）were extracted from the 2019 Global Burden of Disease（GBD）database for males and females in China and females in Japan，Korea，India and globally. R language was used to analyze the data and visualize the analysis of this study. Joinpoint software was used to analyze the trend of PAD prevalence in males and females in China over time from 1990 to 2019，and the annual percentage change（APC）and average annual percentage change（AAPC）of PAD prevalence and their 95% confidence intervals（CI）were calculated. A Bayesian age-period-cohort（BAPC）model was used to predict the number and prevalence of PAD in 2020—2035. Results The estimated prevalence of PAD in China in 2019 was 71.74×100000（25.18%）for males and 213.15×100 000（74.82%）for females. Compared with 1990，the number of PAD cases in 2019 increased by 154.22% in males and 181.27% in females. In 2019，the number of cases and prevalence of PAD among males in Japan，Korea，India and globally were all higher than those in 1990，but the age-standardized prevalence was lower. In 1990，the age-standardized prevalence of PAD among women in China was 57.80% and 76.35% of those in Japan and Korea，1.10 times and 1.33 times of those in Japan and Korea in 2019. The prevalence of PAD in Chinese men was 462.40/100 000 in 1990 and 989.79/100 000 in 2019，with an increase of 114.05%，and showed an upward trend during 1990 to 2019. The prevalence of PAD in Chinese women was 1 321.44 per 100 000 in 1990 and 3 055.85/100 000 in 2019，with an increase of 131.25%，and showed an upward trend from 1990 to 2019. The prevalence of PAD in Chinese women was 3.09 times higher than that of men in 2019. The age-standardized prevalence of PAD in Chinese males was 731.02/100 000 in 1990 and 744.96/100 000 in 2019，with an increase of 1.91%，showed an increasing trend from 1990 to 1993 and from 1993 to 2005，and a decreasing trend from 2005 to 2019. The age-standardized prevalence of PAD in Chinese women was 1 839.43/100 000 in 1990 and 2 022.13/100 000 in 2019，with an increase of 9.93%，showing an increasing trend from 1990 to 2005，and a non-significant trend from 2005 to 2009 and 2009 to 2019（P>0.05）. In 2019，the age-standardized prevalence of PAD in Chinese women was 2.71 times of men. BAPC model predicts that the number of PAD cases will reach 101.30×100，000 in Chinese men and 319.24×100 000 in Chinese women by 2035. In 2035，the number of Chinese women with PAD will increase by 49.77% compared with 2019. In terms of age，the largest number of Chinese women aged 65-69 with PAD in 2019 will be 35.15×100 000，and the largest number of women aged 70-74 with PAD in 2035 will be 55.89×100 000. In 2035，the number of Chinese women aged 40 to 44，45 to 49，50 to 54 and 50 to 59 with PAD will be lower than in 2019，and the number of Chinese women aged 60 to 64，65 to 69，70 to 74，75 to 79，80 to 84，85 to 89，90 to 94 and ≥ 95 with PAD will be higher than in 2019. In 2035，the age-standardized prevalence of PAD in Chinese men and women will be 712.09/100 000 and 1 945.97/100 000，respectively，decreasing by 4.41% and 3.77% compared with 2019. By age，the prevalence of PAD in Chinese women in 2035 will increase with age，and the prevalence of PAD in all age groups will be decreased compared with 2019 except for those aged ≥ 95 years. The disease burden of PAD in China in 2019 can be attributed to six risk factors，including hypertension，smoking，diabetes，renal insufficiency，high-salt diet and lead exposure. The most important risk factor for men was smoking（44.32%），followed by hypertension（18.97%）and diabetes（16.11%）. The most common risk factor for women was hypertension（32.31%），which was followed by diabetes （24.81%）and renal insufficiency（17.27%）. Conclusions The number of cases，prevalence and age-specific prevalence of PAD in Chinese women are significantly higher than those in men，and the age-standardized prevalence has already exceeded that of Japan and Korea. In the foreseeable future，the number of Chinese women suffering from PAD will further increase，and the number of elderly women suffering from PAD will increase more and more obviously. Therefore，more attention should be paid to the changes in gender and age，and gender differences in risk factors of PAD patients，and necessary screening and prevention measures should be taken.
Subjects: Medicine, Pharmacy >> Preclinical Medicine submitted time 2017-12-21 Cooperative journals: 《南方医科大学学报》
Abstract： Objective To investigate the effects of health Qigong Wuqinxi exercise on mild depression in college students and analyze the changes in hydrogen proton magnetic resonance spectra (1H-MRS) in the prefrontal cortex and hippocampus after the exercise. Methods Fifty-eight volunteer college students, including 30 with mild depression and 28 healthy students, were randomized into the intervention group and non-intervention group. The students in the intervention group were asked to practice health Qigong Wuqinxi training for 12 weeks and those in the non-intervention group did not engage in such training.For each subject, BECK Depression Self-reported questionnaire (BDI), Hamilton Depression rating scale (HAMD) score, and the metabolic parameters of 1H-MRS in the prefrontal cortex and hippocampus were evaluated before and after the intervention. Results Before the intervention, the scores of BDI and HAMD in the depression group were significantly higher than that in the control group (P<0.01), and were lowered obviously after the 12-week intervention (P<0.01). Compared with the control group, 1H-MRS in the depression group before intervention showed significantly increased NAA/Cr value in the left prefrontal cortex, Cho/Cr value in the bilateral hippocampus and the left frontal lobe, and Cho/Cr value of the left hippocampus and right frontal lobe (P<0.05) with significantly lowered NAA/Cho value in the bilateral prefrontal and Cho/ NAA value in the right hippocampus (P<0.05). After 12 weeks of intervention, NAA/Cr value in the bilateral hippocampus and the NAA/Cho value in the right hippocampus were significantly lowered (P<0.05), and NAA/Cho value in the right prefrontal and Cho/NAA value in the right hippocampus were significantly increased (P<0.05) in the depression group. Before the intervention, Pearson correlation analysis showed that the scores of HAMD and BDI were positively correlated with Cho/Cr value in the hippocampus and NAA/Cr value in prefrontal lobe (P<0.01) and inversely with NAA/Cho in prefrontal lobe and Cho/NAA value in the hippocampus (P<0.05); after the intervention, the scores of HAMD and BDI were positively correlated with NAA/Cr value in the hippocampus and Cho/Cr value in the left hippocampus (P<0.05). Conclusion Exercise of health Qigong Wuqinxi can reduce depression scale scores in patients with mild depression and improve the metabolic indexes (NAA/Cr and Cho/Cr values) in the prefrontal cortex and the hippocampus.
Subjects: Biology >> Bioengineering submitted time 2017-09-20
Abstract： In this paper, the strain ZZ-46 which could assilimated glucose and xylose simultaneously producing lipid were screened from 10 wild yeast strains from the soil of Nanyang region of henan province. The cell biomass, lipid concentration, lipid content, lipid coefficient and lipid productivty of the strain reached 20.23g/L、9.89 g/L、48.91%、14.64g/100g and 0.083 g•L-1•h-1 respectively by fermenting 120h with 2: 1of glucose and xylose as carbon source. Simultaneous, Lipid-acid component was analyzed, there is almost no difference in lipid-acids component by using different mixed sugar ratios as carbon source and C16 and C18 series are main fatty acids. Oleic acid content is the highest in lipid-acid component, next are linoleic acid, palmitic acid and stearic acid in all samples and the sum account for over 90%. The lipid component of this strain is similar to plant oil and could be used as biodiesel source. The strain was primarily identified as Cutaneotrichosporon dermatis by the morphology feature and 26S rDNA D1/D2 domain sequence analysis, and Trichosporon dermatis homonym.
Subjects: Biology >> Bioengineering submitted time 2017-06-01 Cooperative journals: 《中国生物工程杂志》
Abstract： Objective To investigate the mechanism underlying miR146a participating in the cardiotoxicity of doxorubicin. Methods Rat cardiomyocytes H9c2 were treated with doxorubicin (DOX). After that, the cell viability was detected by CCK-8, the miR146a variation was quantified by qPCR and the change of cleaved Caspase 3 was measured by Western blot (WB). Using CRISPR, two sgRNAs were designed to knockout (KO) the expression of miR146a. The cell viability and cleaved Caspase 3 of miR146a KO cells were respectively detected by CCK-8 and WB. The potential target of miR146a was predicted and validated by luciferase system. The change of target gene after DOX treatment, and the influence of miR146a KO on target gene were detected using WB. Results After DOX treatment, cell viability decreased, the level of cleaved Caspase 3 elevated and miR146a expression increased 3.6 folds. Using CRISPR, miR146a expression was successfully suppressed, with a much higher inhibitory rate than microRNA decoy (88.6% vs 57.6%). miR146a KO significant impeded DOX induced miR146a elevation, cell viability decrement and cleaved Caspase 3 increment. Smad family member 4（Smad4） was proved to be a target of miR146a by informatics prediction and luciferase experiment. The treatment of cardiomyocytes by DOX led to a decrease of Smad4 expression. In miR146a KO cells, the expression of Smad4 increased, which was not changed by DOX treatment. Conclusions In rat cardiomyocytes, miR146a participated in doxorubicin cardiotoxicity through Smad4.
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