A systematic review of medication preferences for depressed patients-- Based on discrete choice experiment and best-worst scaling

Subjects: Medicine, Pharmacy >> Clinical Medicine submitted time 2022-12-01 Cooperative journals: 《中国全科医学》

Ren Yanfeng Liu Shimeng Tao Ying Chen Yingyao

Abstract：

Background Antidepressants are one of the main treatment approaches for depression, and consideration of patient preferences can effectively improve patient medication adherence. Several studies have been conducted to explore the medication choice preferences of depressed patients, but no studies have systematically collated and summarized studies on medication preference choice in depressed patients. Object To systematically review discrete choice experiment（DCE）and best-worst scaling（BWS）about patients’ preferences for depression medication in order to provide reference for clinical rational drug use and future preference studies. Method Using“DCE”“BWS”“depression”“discrete choice experiment”“best-worst scaling”as keywords. Chinese and English literatures were retrieved from domestic and foreign databases as CNKI，Wanfang database PubMed，Web of Science during the inception to Dec. 2021. Data were extracted using an extraction sheet, and a reporting quality assessment was applied to all studies using the PREFS checklist. Attributes included in the study were classified into three categories of outcome, process and cost, and their relative importance was assessed. Results A total of 7 DCEs were identified. Most attributes were related to outcome，followed by process and cost. Summarizing the attributes and the relative importance weights in seven studies, the outcome attribute was the most important，followed by cost and process. Based on the PREFS checklist, one study received a score of four and six studies received a score of three. There is room for improvement in respondents and findings in most studies. Conclusion Outcome are most important for depressed patients on medications, and clinicians and policy makers should focus on this and take patient preferences fully into account. There is room for improvement in current study design of variance reporting and internal quality, like reporting of differences between responders and non-responders, elaborating whether there are significant differences between patients excluded from the analysis and those included, and selecting appropriate survey methods. It is recommended that investigators in the future improve research design with respect to respondents, findings, and internal quality of reporting in order to provide more high-quality evidence for depression medication preference studies.

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