Subjects: Medicine, Pharmacy >> Preclinical Medicine submitted time 2017-12-07 Cooperative journals: 《分子影像学杂志》
Abstract： Objective To explore the effect of extensive resection induced by MRI T2Flair sequence on the prognosis ofglioblastoma. Methods Forty-one cases of anesthesia in patients with intracranial glioblastoma between September 2010 andJanuary 2016 in our Hospital were retrospectively analyzed. Seventeen cases were performed with MRI T2Flair sequence underextended resection of brain glioblastoma patients, 24 cases of control group with T1 enhancement were performed with theremaining resection of brain glioblastoma patients. All cases were applied with intraoperative neural navigation application inthe process of surgery combined with electrical stimulation DTI, cortex, intraoperative ultrasound, intraoperative tumorfluorescence imaging. Postoperative pathology were diagnosed with glioblastoma (GBM). The preoperative and postoperativeMRI T1 enhanced lesions and T2Flair scope were outlined by German making radiotherapy plan system. Image fusion wasconducted. The preoperative and postoperative volume were compared. T1 enhance tumor resection range and T2Flairexcision scope were definited. The patients were followed up to January 2017. The patient underwent postoperativeradiotherapy and chemotherapy. Results T1 enhanced lesions of 24 cases in Control group were excised. No patient hadneurological dysfunction after operation. Another 17 cases of T2Flair patients as extended resection, 7 cases T2Flair had aexcision of 0%~10%, 4 cases of T2Flair had a resection of 10%~25%, 6 T2Flair removed more than 25%. All patients werefollowed up to January 2017, 17 patients with GBM T2Flair excision had a median survival time of 30.45 months. In the controlgroup of 24 cases with GBM patients, median survival time was 15.37 months. Difference between two groups wassignificantly (P=0.013). T2Flair resection were divided into group of 0%~10%, 10%~25% and more than 25%. The mediansurvival time of each group was 20.16, 45, 33 months, respectively, with no significant differences . Conclusion Application ofawaken anesthesia combined with intraoperative neural navigation, electrical stimulation DTI, cortex, intraoperativeultrasound, intraoperative tumor fluorescence imaging can effectively guarantee the operation safety of the intracranial GBMpatients. It improves the T1 enhanced the rate of total resection of lesions like, promotes the maximum safe range to completethe T2Flair extended resection. T2Flair total excision of the expansion can obviously prolong the survival time of GBM patients,but not T2Flair like to remove the more the better. The difference between the survival degree of resection is not significant.
Subjects: Medicine, Pharmacy >> Preclinical Medicine submitted time 2017-12-07 Cooperative journals: 《分子影像学杂志》
Abstract： The medical talents with innovative practice ability are needed increasingly in society at present.Most educators haverealized the significance of the ability to cultivate the comprehensive ability of medical students,but due to the long-terminfluence of the traditional examination oriented education concept, and teachers and students do not pay enough attention topractice, the result is not satisfactory. This paper briefly describes the role of innovative practice ability in the comprehensiveability training as well as the current problems in cultivating innovative practice ability, we put forward some methods ofcultivating innovative practice ability, in order to improve the comprehensive ability of medical students, and lay thefoundation for training high-quality medical talents.
Subjects: Medicine, Pharmacy >> Preclinical Medicine submitted time 2017-12-07 Cooperative journals: 《分子影像学杂志》
Abstract： Objective To normalize the pathological sampling and provide precise information for clinical doctors. Methods We normalized Seven-part sampling method as the standard method of pathological sampling.Seven samples from sevendifferent directions of Glioblastoma (GBM) tumor (central, anterior, posterior, medial, lateral, superior, inferior) were obtainedby neurosurgeon during surgery. Forty glioblastoma patients which had pathological samples through Seven-part SamplingMethod were included. Primary tumor cells cultivation were conducted. The expressions of MGMT、IDH1 proteins weredetected through IHC in these seven tumor samples. Results Tumor cells were cultivated in 100% from tumor tissue which incenter of GBM tumor successfully.The primary tumor cells were spindle-shape with a strong ability of migration and high rateof proliferation. Primary tumor cells were cultivated in other sites of GBM tumor with a successful rate of 60%. The cells wereobtuse-shape with a slower ability of migration and rate of proliferation. The two kinds of primary cells were different of cellmorphology and biology. The expressions of IDH1 protein IHC in 10 cases were significantly different (P=0.001). Theexpressions of MGMT protein in 12 cases were significantly different (P=0.004). Conclusion Seven sites in GBM tumor havetumor cells. The expressions of IDH1 and MGMT proteins are different. The tumor tissue obtained from central site of GBMtumor can reflect the pathological grade of tumor more accurately.The other 6 sites in peritumoral area can reflect themolecular pathology information of these residual tumor cells which cannot be removed by surgery. Seven-part samplingmethod is very important for pathological diagnosis of glioblastoma.
Subjects: Medicine, Pharmacy >> Preclinical Medicine submitted time 2017-12-07 Cooperative journals: 《分子影像学杂志》
Abstract： Objective To explore the relationship between thyroid stimulating hormone (TSH) level and the prognosis ofpatients with thyrotropin-secreting pituitary adenoma. Methods The clinical data of 53 patients with thyrotropin-secretingpituitary adenoma were retrospectively analyzed. Patients were performed with routine treatment after examination. Oneweek before treatment, serum TSH level was detected.According to TSH level, the patients were divided into group I (n=20,TSH level <2.5 m U/L) and group II (n=33, TSH level ≥ 2.5 m U/L). The two groups were followed up for at least 5 years (or tilldeath). The tumor-free survival and total survival were recorded. Results There were no significant differences of gender, ageand tumor size between the two groups (P>0.05). Rate of lymph node metastasis was significantly higher in group II thangroup I (36.36% vs 10.00%, P<0.05). Among all TNM stages, the proportion of stage III~IVwas significantly higher in group IIthan group I (57.58% vs 25.00%, P<0.05). Before treatment, levels of triiodothyronine (T3) and thyroxine (T4) were significantlyhigher in group II than group I (P<0.05). Till February 2017, the 5-year disease-free survival rate and overall survival rate ofgroup II were significantly lower than those of group I (48.48% and 63.64% vs 80.00% and 90.00%, P<0.05). Cox regression riskmodel showed that lymph node metastasis, TNM stage, levels of T3, T4 and TSH were independent factors influencing the 5-year survival rate of patients with thyrotropin-secreting pituitary adenoma (P<0.05). Conclusion High TSH levels areassociated with poor prognosis of patients with thyrotropin-secreting pituitary adenoma. Clinical measures should be taken tocontrol the TSH level of patients.
Subjects: Medicine, Pharmacy >> Preclinical Medicine submitted time 2017-12-07 Cooperative journals: 《分子影像学杂志》
Abstract： Objective Cabrol procedure was introduced by Professor Cabrol C in 1981, but little information existed regardingthe results of Cabrol technique in aortic dissection(AD). This study explored a 7-year period results of aortic root replacementsin type A aortic dissection employing this procedure. Methods From January 2009 to December 2016, 47 patients with type Aaortic dissection received Cabrol procedure in our hospital. All patients received echocardiography and CT scan of whole aortabefore operation. Cabrol procedure was performed to repair the aortic root. The replacement of right hemi aortic arch or totalaortic arch and a stented frozen elephant trunk implantation might be performed based on the extent of the dissection in theaortic arch. A retrospective analysis was performed to evaluate the effectiveness of this procedure in type A aortic dissection.Results Forty-seven cases were admitted, including 6 cases of simple Cabrol procedure, 13 cases with concomitantreplacement of right hemi aortic arch and 28 cases with concomitant total aortic arch replacement and frozen elephant trunktechnique.The 30-day mortality was 10.6%(5/47). 25.5%(12/47) of patients developed acute renal failure, and 12.8%(6/47)needed continuous renal replacement therapy (CRRT) during hospital time. The median hospital time were 25.5 d, rangingfrom 15 to 128 d.It followed-up from 6 to 36 months. Conclusion The Cabrol procedure is feasible and safe for patients withtype A aortic dissection. The artificial blood vessels are unobstructed.
Subjects: Medicine, Pharmacy >> Preclinical Medicine submitted time 2017-12-07 Cooperative journals: 《分子影像学杂志》
Abstract： Objective To investigate the effect of modified Hyper-CVAD therapy on elderly patients with p H negative acutelymphoblastic leukemia (ALL) secondary hyperglycemia and explore the relation between prognosis and hyperglycemia.Methods Seventy-two elderly patients (≥55) with p H -negative ALL were enrolled in the study. The patients were randomlydivided into 2 groups with 36 patients in each group. Patients in group A were performed with improved Hyper-CVADtherapy. Group B were performed with routine Hyper-CVAD therapy. The clinical features, secondary hyperglycemia and thesurvival status after chemotherapy were compared between the two groups before and after chemotherapy. The patients werefollowed up for 3 years. Results The random blood sugar of control group on the third weekend was higher than that of theobservation group, and higher than that of the first weekend in control group (P<0.05). Fasting blood glucose and bloodglucose were higher on the fourth weekend in the two groups than that in the first weekend (P<0.05). The random blood sugarin control group was significantly higher than that in observation group (P<0.05). There was no significant difference of fastingblood glucose between the two groups (P<0.05). The proportion of secondary hyperglycemia in control group was 22.22%,which is significantly higher than that of observation group(5.56%). There was no significant difference of recurrence rate andsurvival rate between the two groups. Fasting and random blood glucose on the fourth week of the two groups were correlatedwith infection, remission rate, relapse rate and overall survival rate.There were 11 and 14 cases recurred respectively in the twogroups, with no significant difference (30.56% vs 38.89%, P=0.458). Nine cases and 12 patients died respectively in the twogroups, with no significant difference(75.00% vs 67.67%, P=0.437). Conclusion The improved Hyper-CVAD therapy caneffectively reduce the risk of secondary hyperglycemia induced by chemotherapy on elderly patients with Ph-negative acutelymphoblastic leukemia.
Subjects: Medicine, Pharmacy >> Preclinical Medicine submitted time 2017-12-07 Cooperative journals: 《分子影像学杂志》
Abstract： Objective To explore the intelligent management of personnel, articles and equipment in operation room throughradio frequency identification technology. Methods A toltal of 200 patients in our hospital were selected, which 100 patientswere used as observation group with radio frequency identification.The other 100 patients were treated as control group withroutine manual management method, such as manual check of medical staff and patient’s identification, preoperativeequipment and articles preparation. Preparation before surgery, goods in and out of warehouse and infection after surgerywere observed.The equipment delivery rate, operation frequency and cost, the satisfaction of medical staff and patients, theworking quality of operation room were compared. Results The preparation time before surgery, the error rate and the rate ofinfection after surgery in observation group were lower than those in control group (P<0.05). The effective utilization rate ofthe observation group was 99%.The average daily operation quantity was 5.38±1.23, the average cost was 5482.38±1231.23yuan, and the results were better than that of the control group (P<0.05). Patients satisfaction of observation group was 96%,the doctor satisfaction was 94%, nursing satisfaction was 97%.Work quality assessment score of operation room weresignificantly higher than that of the control group(P<0.05). Conclusion Radio frequency identification technology can realizethe comprehensive management of goods, equipment and personnel of the operation room. It improves work efficiency,reduces the incidence of medical accidents and cost.
Subjects: Medicine, Pharmacy >> Preclinical Medicine submitted time 2017-12-07 Cooperative journals: 《分子影像学杂志》
Abstract： Objective To evaluate the diagnostic value of spiral CT multiplanar reconstruction in traumatic carpaldislocation orfracture-dislocation. Methods The clinical and imaging data of 48 cases confirmed of carpal dislocation or fracture-dislocationwere retrospective analyzed.The diagnostic accuracy of plain film radiography, CT (axial, MPR and VRreconstructionincluded) in the diagnosis of wrist dislocation were compared. Results In 48 patients diagnosed by clinical data,accuracy of spiral CT was 100% and accuracy of plain film radiography was 70.83%. There was significant difference ofcarpaldis location detection between CT and X-ray (χ2=4.5, P<0.05). Ten cases were unable to detect the small fractures ofscaphoid and triquetrum in the X-ray missed cases. Four cases were misdiagnosed in plain film which pisiform was the mostcommon. Conclusion Small carpal fractures may be missed even in a high detection rate of carpal dislocation in X-ray. MPRand VR reconstruction of spiral CT can clearly show carpal dislocation and fracture, provide imaging supports for clinicaltreatment. In addition, misdiagnosis of dislocation of some carpal in the plain film are caused by the passive position ofpatients.
Subjects: Medicine, Pharmacy >> Preclinical Medicine submitted time 2017-12-07 Cooperative journals: 《分子影像学杂志》
Abstract： Objective To explore the correlation of carotid ultrasound parameters, dynamic arterial stiffness index (AASI) andcoronary heart disease (CHD). Methods AASI, carotid ultrasound and coronary angiography were detected in 110 patientswith CHD. According to the result of coronary angiography, patients were divided into single lesion group (n=40), two lesiongroup (n=37) and 3 or more lesion group (n=33). Based on carotid ultrasound examination, patients were divided into carotidmild stenosis group (n=42), moderate stenosis group (n=46) and severe stenosis group (n=22). Fifty cases with healthy physicalexamination were selected as the normal control group. Blood pressure, AASI, carotid intima-media thickness (IMT), carotidatherosclerosis plaque integral and coronary artery score were compared in 4 groups with correlation analysis. Results Therewere no significant differences in systolic blood pressure and diastolic blood pressure between patients with different coronarylesions and different degrees of carotid stenosis (P>0.05). The differences of AASI between 3 lesions group, two single lesiongroup and the control group were significant (P<0.05). The differences of AASI between severe carotid stenosis group,moderate stenosis group, mild stenosis group and the control group were significant (P<0.05). IMT of patients with CHD weresignificant higher than that of control group (P<0.05). But IMT between coronary heart disease group were not significantdifferent (P>0.05). Coronary plaque integral score between 3 lesion group, two lesions in group 1 lesion group and controlgroup were significant different (P<0.05). Coronary plaque integral score between severe stenosis, moderate stenosis group,mild stenosis group and control group were significant different (P<0.05). AASI and coronary lesions, stenosis were correlatedpositively (r=0.72, 0.65, P<0.05). Plaque scores and scores of coronary artery were positively related to the coronary lesions andcarotid artery stenosis (r=0.88, 0.19, 0.88, 0.19, P<0.05). Conclusion The parameters of carotid artery ultrasound and AASI canobjectively reflect the degree of atherosclerosis and atherosclerotic plaques. It can early predict, evaluate the risk of coronaryheart disease and provide reliable basis for early clinical intervention.
Subjects: Medicine, Pharmacy >> Preclinical Medicine submitted time 2017-12-07 Cooperative journals: 《分子影像学杂志》
Abstract： Objective To analyse the clinical history combined with routine lip jaws on the three aspects, alveolar suddentransverse section, other special plane and three-dimensional ultrasound fetal position,and improve the efficiency of prenatalultrasound diagnosis of fetal cleft lip and palate. Methods The facial ultrasound screening were performed to 7000 fetus in thesecond trimester in our hospital from September 2014 to December 2016. Medical history were asked before ultrasoundexamination. We standardized the conventional three section, alveolar cross section as a screening section. A two-dimensionalimage were collected at the same time of opening and closing of the fetal anomaly. 3D acquisition the image were collected atlast. The induction of labor or delivery in children after facial results were compared.The effects of prenatal ultrasound ofdifferent methods in diagnosis of cleft lip and palate efficiency were compared. Results In 7000 cases of fetal ultrasonography,27 cases were detected of cleft lip and palate, 29 cases were confirmed of cleft lip and palate by labor and childbirth.Twentycases were detected of cleft lip and cleft palate in the conventional three section group. Nine cases were missed diagnosis ofprenatal ultrasound. Coincidence rate of ultrasound diagnosis was 69%. 27 cases were fetal cleft lip and palate malformation byconventional three aspects, alveolar sudden transverse section, other special section on three-dimensional ultrasound group.Two cases were missed diagnosis of prenatal ultrasound. Coincidence rate of prenatal ultrasound diagnosis was 93%. Effects oftwo methods in the merger of cleft lip cleft palate cases were significantly different (P<0.05). Conclusion Ultrasound doctorsshould do conventional acquisition history before examination.The identification of normal structure and sonographic featuresof cleft lip and palate nose, the conventional three section on the alveolar transverse section, a careful observation of the fetallip nasal structure and closed mouth movement, the application of three-dimensional ultrasound surface imaging mode willimprove ultrasound diagnostic rate of cleft lip and palate deformity.It can provide reliable informations for clinicians andpregnant women.
Subjects: Medicine, Pharmacy >> Preclinical Medicine submitted time 2017-12-07 Cooperative journals: 《分子影像学杂志》
Abstract： Objective To explore the relationship between structure and function of SR and DAO in schizophrenia. Methods SRand DAO gene were cloned from blood of patients with schizophrenia with bioinformatics analysis. Results The SR and DAOgenes encoded 340 and 347 amino acids, respectively. It had more than 96% homology with healthy humans, apes andmonkeys. The relative molecular mass of SR and DAO proteins were predicted to be 36.57 KDa and 39.47 KDa, respectively.The isoelectric point were 6.11 and 6.36. SR distribution was involved in chondriosome. DAO distribution was involved inchondriosome and peroxysome. It indicated that SR and DAO played a mayor role in synthesis and metabolism of cells.Three-dimensional measurement revealed that SR protein was composed of a structural domains and DAO protein was composed oftwo structural domains and one link region. Conclution SR and DAO can promote protein synthesis and metabolism ineukaryotic cells.
Subjects: Medicine, Pharmacy >> Preclinical Medicine submitted time 2017-12-07 Cooperative journals: 《分子影像学杂志》
Abstract： Objective To explore the effect of 6 sigma management model on nursing in patients with gastric cancer aftergastratrophia with physiological index, nursing quality and cost management. Methods A total of 200 patients whounderwent subtotal resection of gastric cancer in our hospital were selected.In which 100 patients were used as control groupwith routine management method and the other were treated as observation group with 6-sigma management model. Pain,anxiety and physiological indexes of the patients in different time periods were compared. Nursing quality, satisfaction,hospitalization time and hospitalization costs were observed. Results After performing 6-sigma, pain and anxiety scores of theobservation group were lower than that of control group at the fifth day after operation and 1 d before discharge. Inobservation group, patients’ satisfaction (93%), nurses’ satisfaction (95%) was significantly higher than that in controlgroup.Hospital stays (13.5±3.1) in observation group was shorter than that in control group. Total hospital expenses(24588.3±4282.2), daily hospital expenses (1832.2±323.6) were significantly lower in observation group than control group.Conclusion Six-sigma management is beneficial for relieving anxiety of patients with gastric cancer resection. It can reducepain, improve nursing quality, cut down hospital stay and hospitalization expenses and enhance patients and nurses’satisfaction.
Subjects: Medicine, Pharmacy >> Preclinical Medicine submitted time 2017-12-07 Cooperative journals: 《分子影像学杂志》
Abstract： Objective To investigate the effect of secreted Hsp90α (e HSP90α) on the development and progression of coronaryheart disease (CHD). Methods A total of 101 patients with CHD and 31 cases as healthy control group were enrolled in thisstudy from June 2013 to June 2016. The e HSP90 αlevels in peripheral blood of all cases were collected. The correlation ofe HSP90α levels in peripheral blood with condition of patients with CHD was analyzed. Results The e HSP90α levels inperipheral blood of patients with CHD was significantly higher than that of healthy control group (P<0.01). In patients withCHD, e HSP90α levels in peripheral blood in unstable CHD group was significantly higher than that in stable CHD group(P<0.01). The e HSP90α levels in peripheral blood in CHD combined with heart failure was significantly higher than that inpatients group without heart failure (P<0.05). The e HSP90α levels in peripheral blood of CHD patients with grade Ⅳ heartfailure had no significant difference with grade III heart failure patients (P=0.158). Conclusion The e HSP90α levels inperipheral blood are closely related to the condition of CHD in Guangdong. It may be a serological marker of coronary heartdisease by further study.
Subjects: Medicine, Pharmacy >> Preclinical Medicine submitted time 2017-12-07 Cooperative journals: 《分子影像学杂志》
Abstract： Objective To investigate the feasibility, safety, practicality and ease operation of micro laparoscopic surgical TAPPumbilical single parts in clinical application. Methods Seventy-one cases were performed with umbilical TAPP microlaparoscopic operation in our hospital since 2015. A total of 100 cases without tension hernia repair were randomly chosed. Theoperation time, intraoperative blood loss, postoperative incision pain, satisfaction of incision, scrotal hematoma, incisioninfection,antibiotic usage and postoperative hospital stay were compared between 2 groups. TAPP micro laparoscopic surgeryby umbilical single parts were repaired by bud in 3 d Max patch.Traditional cases without tension hernia repair patch haddifferent specifications. Results Two groups of patients achieved surgical success. Operation time, intraoperative blood loss,postoperative incision pain, aesthetic satisfaction, antibiotic usage of incision, postoperative hospital stay in the umbilicalsingle parts micro laparoscopic TAPP group is superior than that of the traditional group, with same incision infection rate andscrotal hematoma. During followed-up years(2 �0.5), there were no recurrence of hernia and other complications. Conclusion The umbilical single site TAPP micro laparoscopic surgery have a clear anatomy, simple operation, clinical operationfeasibility. It is worth of clinical promotion with safety, practicality and simplicity.
Subjects: Medicine, Pharmacy >> Preclinical Medicine submitted time 2017-12-07 Cooperative journals: 《分子影像学杂志》
Abstract： Objective To evaluate the effect of tea polyphenols on sinus healing in post-operative radioactive osteomyelitis ofjaws (ORN) by cone beam CT and contrast fistulography. Methods Thirty ORN cases with post-operative oral mucosa sinuswere divided into 2 groups randomly. In experimental group, sinus was rinsed and gargled with tea polyphenols solution indaily. In control group, sinus was treated with normal saline. Sinus radiography was taken by cone beam CT every 3 weekswith calculation of sinus volume in 2 groups. Effect of tea polyphenols on proliferation of human immortalized oral mucosalepithelial cell line was detected by MTT. Results The sinus volume in experimental group was smaller than that in controlgroup after 12 weeks of treatment (P<0.05). With treatment of 120 mg/L tea polyphenols, growth rate of NOK in experimentalgroup was higher than that of control group (P<0.05). Conclusion Tea polyphenols can accelerate the healing of post-operativesinus in ORN through stimulating the proliferation of epithelium cell.
Subjects: Medicine, Pharmacy >> Preclinical Medicine submitted time 2017-12-07 Cooperative journals: 《分子影像学杂志》
Abstract： Objective To investigate the clinical and laboratory characteristics of severe pneumonia during pregnancy. Methods Eighteen cases of pneumonia with pregnant in our department from March 2013 to October 2016 were retrospectivelyanalyzed. Nine cases recieved tracheal intubation and the other 9 cases were not.Clinical manifestations, biochemical andinfection indicators during admission, hospital days, pregnant women and fetal outcomes were analyzed. Results There wereno significant differences of pregnancy times between two groups.But the delivery times of two group were significantlydifferent(1.7�.1 vs 0.7�.7, P=0.038); Difference of gestational weeks in two groups was not significant(P>0.05).Theconcentration of hemoglobin and serum albumin was low in patient with pneumonia, but there was no significant differencebetween two group(P>0.05); ICU stay in intubated group and non intubated group were significantly different(P<0.05).Nopregnant women died in non intubatd group, 2 casesin intubated group died(2/9). Conclusion The more the failure ofpregnancy, the higher the rate of intubation after pneumonia.Pneumonia may be more severe in the second trimester.Patientswith low hemoglobin and albumin are predisposed to intubation.Patients of pregnancy complicated with pneumonia inintubation have a longer ICU stay and a high mortality.
Subjects: Medicine, Pharmacy >> Preclinical Medicine submitted time 2017-12-07 Cooperative journals: 《分子影像学杂志》
Abstract： Objective To investigate the CT features and evolution of lung abnormalities in patients suffered from acutepulmonary embolism. Methods The CT and clinical data of 34 patients suffered from acute pulmonay embolism wereanalyzed retrospectively. The direct sign, that is, thefilling defect within the pulmonary arteries, and the abnormal CT signs inthe lungs, including pulmonaryinfarction, mosaic sign, ground-glass opacity, Westermark'ssign, and pulmonary atelectasiswere assessed, and their location and radiologic features of lesions were described too. On the follow-up CT examinations, theevolution of lesions were carried out by comparing to their appearance shown on previous CT images. Results On initial CTexminations, pulmonaryinfarction involved 18 patients, resulting to 28 lesions, while mosaic sign involving 6 patients,resulting to 10 lesions, ground glass opacity involving 12 patients, resulting to 28 lesions, Westermark'ssign involving 5patients, resulting to 6 lesions, and pulmonary atelectasis involving 13 patients, resulting to 19 lesions. Thirteen patientspeformed at least one time follow-up CT exminations in various period. As the filling defectdecreased while followed up,almost of the lung abnormalities shrinked or disappeared on CT, but the pulmonaryinfarction turned to be focal fibrosislesions. Conclusion Pulmonaryinfarction, mosaic sign, ground-glass opacity, Westermark'ssign, and pulmonary atelectasiswere common signs on CT in patients suffered from acute pulmonary embolism, and acknowledging the signs and theirevolution would contribute to the diagnosis and therapeutic effects evaluation of pulmonary embolism.
Subjects: Medicine, Pharmacy >> Preclinical Medicine submitted time 2017-12-07 Cooperative journals: 《分子影像学杂志》
Abstract： Objective To investigate the nursing measures of phlebitis caused by MRI contrast agent leakage. Methods Fiftycases of phlebitis caused by MRI contrast agent leakage were selected to receive a retrospective analysis.Twenty-five phlebitispatients with routine nursing were divided into the control group and other 25 phlebitis patients with effective nursing weredivided into experimental group . Nursing satisfaction and efficacy of the two groups were compared. Results Nursingsatisfaction rate of the experimental group was significantly higher than that of the control group (P<0.05).Total effectivenursing rate of the experimental group was significantly higher than that of the control group (P<0.05). Conclusion Theeffective nursing measures can improve patient’s condition, treatment efficacy and nursing satisfaction.
Subjects: Medicine, Pharmacy >> Preclinical Medicine submitted time 2017-12-07 Cooperative journals: 《分子影像学杂志》
Abstract： Objective To access the effect of advanced glycation end products（AGEs） on oocyte quality and granulosa cellfunction for patients with tubal factor infertility. Methods From February 2015 to June 2015, 19 IVF patients with tubal factorwere enrolled. All patients were <35 years old.They were controlled ovarian hyperstimulation (COH) with long-acting longprotocol and retrieved ≥8 oocytes. Their follicular fluid and granulosa cells were collected during ovum pick-up (OPU) andcryopreserved at –80 ℃. The patients were devided into 2 groups: Group A of 10 patients with high quality embryo rate >35%and group B of 9 patients with high quality embryo rate <35%. Follicular fluid AGEs and ROS levels on OPU day were detectedby sandwiched ELISA, and the RAGE m RNA expression of granulosa cells were detected by Real-time PCR. Results Therewere no significant differences of general informations between two groups (P>0.05). There were significant differences inaverage numbers of high quality embryos (5.2±2.34 vs 1.50±1.08, P=0.001) and the high quality embryo rate (60.27±12.48 vs21.48±14.02, P=0.000). Follicular fluid ROS levels in 2 groups were significantly different (0.82±0.28 vs 1.11±0.27 ng/m L,P=0.000). The follicular fluid AGES level in 2 groups were not significantly different (0.33±0.13 vs 0.35±0.13 μg/m L, P=0.462).Conclusion The oxidative status may be the reason of oocytes dysplasia in the young patients with tubal factor infertility. ButAGES-RAGE probably was not the mechanism.
Subjects: Medicine, Pharmacy >> Preclinical Medicine submitted time 2017-12-07 Cooperative journals: 《分子影像学杂志》
Abstract： Objective To explore if amniocentesis in pregnant with HBV infection carriers will increase the risk of mother-to-child transmission(MTCT). Methods All relevant published papers and abstracts of English and Chinese were searched by thekey words such as hepatitis B virus/HBV, amniocentesis, vertical/mother-to-child transmission in Pubmed (MEDLINE),Embase, Google scholar and Wanfang database between January 1 1990 and March 15 2016. Four papers with 3997 pregnantwomen including 167 amniocentesis cases and 3830 control cases were entered to this analysis. The analysis was performed bystatistical software Review Manager Version 5.0. Results The meta-analysis showed that there was no significant difference ofinfant’s HBs Ag-positive rate between two groups of mothers who underwent amniocentesis or no amniocentesis (R2=1.37, 95%CI: 0.70~2.69, P=0.36). It increased the risk of MCTC of HBV if amniocentesis was performed in pregnant women with serumHBV-DNA≥107 copies/m L (R2=9.54, 95% CI: 3.52~25.85, P<0.0004) and/or HBe Ag-positivity (R2=3.41, 95% CI: 1.05~11.13,P=0.04). Conclusion Amniocentesis in pregnant women with serum HBV-DNA ≥107 copies/m L and/or HBe Ag-positivitywould increase the risk of MTCT in HBV infection.
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