Subjects: Medicine, Pharmacy >> Preventive Medicine and Hygienics submitted time 2023-03-28 Cooperative journals: 《中国全科医学》
Abstract： Background Intermittent fasting refers to the eating pattern in which the individual abstains from eating food for a certain period during a day or week. As research deepens，intermittent fasting has been shown to play an important role in the prevention and treatment of chronic diseases. Objective We aimed to provide a visualization analysis of the research hot spots and trends in international intermittent fasting studies over the past decade，in order to provide references and basis for future relevant research. Methods Existing studies on intermittent fasting published from January 2010 to April 2022 were retrieved from the Web of Science Core Collection on April 26，2022. CiteSpace was used to examine the distribution of disciplines，authors and institutions cooperation，high-frequency keywords，and keywords with citation bursts of the included literature，and finally relevant maps were created. Results A total of 2786 articles were ultimately included. The number of these publications showed an increasing trend year by year from 2010 to 2022，although the global research level remained uneven. The country with the highest number of publications was the United States（n=650），the institution with the highest number of publications was the University of Illinois（n=49），and the author with the most publications was Professor Krista A Varady of the University of Illinois（n=26）. The high-frequency keywords included weight loss，intermittent fasting，obesity，insulin resistance，metabolism，caloric restriction，gene expression，circadian rhythms，and diet. The research themes were renamed as food intake restriction，circadian rhythms，weight control，metabolic-related diseases and other diseases，and related mechanisms after the cluster analysis. Burst keywords included time-restricted feeding，suprachiasmatic nucleus，mice，growth，and mortality. Conclusion The research hot spots of intermittent fasting are mainly focused on its relationship with biological rhythms/circadian rhythms，its effect on improving chronic diseases and other diseases，and sensitive genes and related mechanisms. Future research should focus on intermittent fasting in different populations such as children/adolescents，pregnant women，the elderly，and professional athletes/fitness enthusiasts，and clinically evaluate and compare the intervention effects and safety of different intermittent fasting patterns，ultimately forming a personalized intermittent fasting intervention model and exploring its biological mechanism.
Subjects: Medicine, Pharmacy >> Clinical Medicine submitted time 2022-11-23 Cooperative journals: 《中国全科医学》
Abstract：
Objective We aimed to provide global reference and basis for future research in intermittent fasting by visualization analysis, which included the hot spots and trends in a decade. Methods The literatures of IF from January 2010 to January 2022 were retrieved from the Web of Science core database. The included literatures were analyzed by Cite Space, which involved the distribution of disciplines, author cooperation, institutional cooperation, high frequency keywords and emergent citation keywords, and finally we draw the correlations maps. Results and Conclusion (1) 2786 relevant literatures were finally included. Though the number of IF related papers increased year by year during 2010 to 2022, the level of global research remained imbalance. The country with the highest volume is the United States, the institution with the most publications is the University of Illinois, and the highest posting author is Professor Krista A Varady from the University of Illinois. (2) The hot spots mainly focus on the relationships of biological/circadian rhythms; the improvement effects of chronic and other diseases; sensitive genes and related mechanisms. (3) Future research could keep eye on different groups such as children, adolescents, pregnant women, the eldly and professional athletes/ exercise and fitness enthusiasts, and explore the effects and safety comparison of IF intervention with different patterns in clinical application. Finally, a personalized IF intervention patterns will be formed and we can explore its biological mechanisms.
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