Subjects: Medicine, Pharmacy >> Clinical Medicine submitted time 2018-10-26 Cooperative journals: 《协和医学杂志》
Abstract： Venous thromboembolism is a serious complication after orthopedics arthroplasty, which could result in significant loss of patients’satisfaction of artificial joint. In some extreme cases, it also could lead to deaths of patients owing to respiration and circulation failure. The most important and effective method to prevent this complication is anti-coagulation therapy preoperative, that could greatly reduce the incidence of venous thromboembolism after arthroplasty. Anticoagulant drugs, such as low molecular weight heparin, Xa factor inhibitors, are first choices for anti-coagulation therapy after arthroplasty. These drugs have certain effect and low risk of bleeding postoperative, but there are still some deficiencies, including expensiveness, injections and so on. Aspirin is a historical antiplatelet drug, now some guides and researches suggest it also can be a choice for prevention venous thromboembolism after arthroplasty. In these researches, they found aspirin has similar prophylactic effect and safety compared to anticoagulant drugs of prevention of venous thromboembolism after arthroplasty. Aspirin is cheaper, economical, and it could be oral application, that is convenient for patients. Some researchers also believe aspirin has lower bleeding rates compared with anticoagulant drugs. In terms of drugs doses, low dose aspirin could have sufficient preventive effect for venous thromboembolism, and that could reduce the gastrointestinal adverse reactions of aspirin. In conclusion, aspirin is a new choice for prevention of venous thromboembolism after arthroplasty
Subjects: Biology >> Zoology submitted time 2017-10-10 Cooperative journals: 《动物营养学报》
Abstract：肥胖是由多因素引起的一种慢性代谢性疾病，也是一种系统性的低度炎症，同时影响着机体的能量代谢和免疫状态。大量研究报道，肥胖在一定程度上影响了呼吸系统的功能，增加了呼吸道感染的风险，同时调节了机体清除病原体的能力，使机体预后出现两极化。目前这种机制尚不清楚，明确的是脂肪组织的大量堆积，使炎性细胞浸润增加，炎性介质和脂肪因子的表达水平提高，这可能是肥胖改变肺脏对病原微生物敏感性的主要原因。本文就肥胖影响呼吸道抗感染的可能机制作一简要阐述，为深入探究肥胖与呼吸道感染之间的关系奠定一定的基础。
Subjects: Biology >> Botany submitted time 2018-05-07 Cooperative journals: 《广西植物》
Abstract：通过野外调查、标本采集以及查阅相关的文献资料，对西藏佩枯错种子植物区系进行统计分析。结果表明：1）植物种类较贫乏。佩枯错共有种子植物31科、77属、115种，仅占西藏种子植物的18.90%、6.73%、2.17%。其中裸子植物2科、2属、2种，被子植物29科、75属、113种；被子植物中双子叶植物有23科、58属、91种，单子叶植物6科、17属、22种。2）优势科明显，单种科占绝对优势。所有科中有5个科至少含有7种种子植物，占该研究区总种数的39.13%，是该区系的主要组分；同时科数中有11科仅含1种植物，该类科占一定优势。3）种子植物的区系成分较复杂，划分为3个科分布区类型和10个属分布区类型，其中温带成分占绝对优势：温带分布科、属分别占总数的29.03%和77.92%，表明本区系具有明显温带性质。4）科属特有现象不明显，没有中国特有科分布，仅有1个中国特有属分布，说明佩枯错植物区系的特有化程度极低，表现出寒旱化与高山、高原特化综合而成的高寒植物区系的年轻性。5）本研究结果，对丰富西藏高原植物区系地理研究资料，为深入开展该区域植被生态学研究、生物资源开发利用与保护提供参考依据，为西藏生态文明建设推进、构建国家生态安全屏障提供基础资料。
Subjects: Medicine, Pharmacy >> Preclinical Medicine submitted time 2017-12-27 Cooperative journals: 《南方医科大学学报》
Abstract： Objective To investigate the relationship between polymorphisms of surfactant protein D (rs3088308 and rs721917) and the susceptibility to silicosis. Methods This case-control study included 125 silicosis patients and 125 individuals exposed to industrial dust but without silicosis (control group), who were strictly matched with the case group for age, gender, work type and cumulative length of dust exposure. The rs3088308 and rs721917 polymorphisms of surfactant protein-D were detected in all the participants using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). Results The frequencies of T/T, T/A and A/A genotypes of surfactant protein-D rs3088308 locus were 22.2%, 71.2% and 5.6% in the case group, significantly different from the frequencies of 17.6%, 58.4% and 24.0% in the control group, respectively (P< 0.05). The frequencies of C/C, C/T and T/T genotypes of rs721917 locus were 17.6%, 56.8% and 25.6% in the case group, similar to the frequencies of 15.2% , 60.0% and 24.8% in the control group, respectively (P>0.05). Conclusion Surfactant protein-D rs3088308 polymorphism is significantly associated with silicosis, and the T allele may be a risk factor for silicosis in individuals exposed to industrial dust.
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