分类： 医学、药学 >> 临床医学 提交时间： 2022-12-22
摘要： Objective: Delayed or missed doses are unavoidable in the pharmacotherapy of epilepsy and significantly compromise the efficacy of antiepileptic drug treatment. An inappropriate remedial regimen can cause seizure relapse or serious adverse events. This study investigated the effect of delayed or missed doses on the pharmacokinetics (PK) of valproic acid (VPA) in patients with epilepsy and established remedial dosing recommendations for nonadherent patients. Methods: Monte Carlo simulations are based on all previous population pharmacokinetic models for pediatric, adult and elderly patients with epilepsy. The following four remedial strategies were investigated for each delayed dose: A) A partial dose or a regular dose is taken immediately; a regular dose is taken at the next scheduled time. B) The delayed dose was administered immediately, followed by a partial dose at the next scheduled time. C) The delayed dose and a partial dose are taken; the next scheduled time is skipped, and the regular regimen is resumed. D) Double doses are taken when missed one dose or two doses, and the regular regimen at the subsequent scheduled time is resumed. Results: The recommended remedial dose was related to the delay duration and daily dose. Remedial dosing strategies A and B were almost equivalent, whereas Strategy C was recommended when the delayed dose was close to the next scheduled dose. Strategy D was only suggested for delayed two doses. Conclusion: Simulations provide quantitative insight into the remedial regimens for nonadherent patients, and clinicians should select the optimal regimen for each patient based on the individual's status.
分类： 天文学 >> 天文仪器与技术 提交时间： 2024-01-22 合作期刊: 《天文技术与仪器（英文）》
摘要：An extreme ultraviolet solar corona multispectral imager can allow direct observation of high temperature coronal plasma, which is related to solar flares, coronal mass ejections and other significant coronal activities. This manuscript proposes a novel end-to-end computational design method for an extreme ultraviolet (EUV) solar corona multispectral imager operating at wavelengths near 100 nm, including a stray light suppression design and computational image recovery. To suppress the strong stray light from the solar disk, an outer opto-mechanical structure is designed to protect the imaging component of the system. Considering the low reflectivity (less than 70%) and strong-scattering (roughness) of existing extreme ultraviolet optical elements, the imaging component comprises only a primary mirror and a curved grating. A Lyot aperture is used to further suppress any residual stray light. Finally, a deep learning computational imaging method is used to correct the individual multi-wavelength images from the original recorded multi-slit data. In results and data, this can achieve a far-field angular resolution below 7", and spectral resolution below 0.05 nm. The field of view is ±3 R☉ along the multi-slit moving direction, where R☉ represents the radius of the solar disk. The ratio of the corona's stray light intensity to the solar center's irradiation intensity is less than 10−6 at the circle of 1.3 R☉.
点击量
待评议
点击量
下载量
评论
通过
