分类: 环境科学技术及资源科学技术 >> 环境科学技术基础学科 提交时间: 2019-10-26 合作期刊: 《干旱区科学》
摘要: Water resources are critical for the existence and development of oases in endorheic basins. Thus, to enable sustainable development, it is fundamentally important to understand how to allocate and use these resources in a reasonable way. We therefore simulated and analyzed changes in water consumption pattern within the Dunhuang Oasis of China under three scenarios using a system dynamic model that corresponds to different water consumption pattern. This was done to assess the impacts of regional water resource planning (comprehensive planning of the rational use of water resource and protection of ecosystem services in the Dunhuang Basin) on water consumption pattern within the Dunhuang Oasis. The first of these, Scenario 1, is a baseline in which the status quo is maintained, while Scenario 2 incorporates the comprehensive effects of agricultural water-saving irrigation measures with an inter-basin water diversion project, and Scenario 3 focuses on ecological rehabilitation. In the baseline Scenario 1, the total water consumption within the Dunhuang Oasis increased progressively while agricultural water consumption remained extremely high and threatened overall ecological security. In contrast, Scenario 2 would decrease agricultural water consumption by almost 5.30×107 m3 following the implementation of water-saving practices. The additional water allocated from an inter-basin water diversion project would play an important role in alleviating ecological strain on the oasis. Finally, in Scenario 3, the total irrigated land must be decreased to 20.6×103 hm2 by 2025 assuming that water supply for ecosystem restoration would be at least 50% of the total consumption. Although water resource planning plays a very important role in alleviating the ecological water crisis within the oasis, it is necessary to consider the suitable scale of oasis with regard to current water consumption pattern.
分类: 医学、药学 >> 临床医学 分类: 生物学 >> 遗传学 提交时间: 2020-03-06
摘要: Germline polymorphisms have been linked with differential survival outcomes in cancers but have not been well studied in nasopharyngeal carcinoma (NPC). Here, two-phase association study is conducted to discover germline polymorphisms that are associated with the prognosis of NPC. The discovery phase includes two consecutive hospital cohorts of patients with NPC from Southern China. Exome-wide genotypes at 246,173 single nucleotide polymorphisms (SNPs) are determined, followed by survival analysis for each SNP under Cox proportional hazards regression model. Candidate SNP is replicated in another two independent cohorts from Southern China and Singapore. Meta-analysis of all samples (n = 5,553) confirm that the presence of rs1131636-T, located in the 3′-UTR of RPA1, confers an inferior overall survival (HR = 1.33, 95% CI = 1.20-1.47, P = 6.31 × 10-8). Bioinformatics and biological assays show that rs1131636 has regulatory effects on upstream RPA1. Functional studies further demonstrate that RPA1 promoted the growth, invasion, migration, and radioresistance of NPC cells. Additionally, miR-1253 has been identified as a suppressor for RPA1 expression, likely through regulation of its binding affinity to rs1131636 locus. Collectively, these findings provide a promising biomarker aiding in stratifying patients with poor survival, as well as a potential drug target for NPC.