分类： 光学 >> 量子光学 提交时间： 2023-02-19
摘要： The multimode waveguide bends (MWBs) with very compact sizes are the key building blocks in the applications of different mode-division multiplexing (MDM) systems. To further increase the transmission capacity, the silicon multimode waveguide bends for dual polarizations are of particular interest considering the very distinct mode behaviors under different polarizations in the silicon waveguides. Seldom silicon MWBs suitable for both polarizations have been studied. In this paper we analyze several dual-polarization-MWBs based on different bending curve functions. These special curve-based silicon MWBs have the advantages of easy fabrication and low loss compared with other structures based on the subwavelength structures such as gratings. A comparison is made between the free-form curve, Bezier curve, and Euler curve, which are used in the bending region instead of a conventional arc. The transmission spectra of the first three TE and TM modes in the silicon multimode waveguide with a core thickness of 340 nm are investigated. The simulation results indicate that in the premise of the same effective radius which is only 10 in this paper, the 6-mode MWB based on the free-form curve has the optimal performances, including an extremely low loss below 0.052dB and low crosstalk below -25.97dB for all six modes in the wide band of 1500-1600 nm. The MWBs based on the Bezier and Euler curve have degraded performances in terms of the loss and crosstalk. The results of this paper provide an efficient design method of the polarization insensitive silicon MWBs, which may leverage the researches for establishing complicated optical transmission systems incorporating both the MDM and polarization-division multiplexing (PDM) technology.
分类： 医学、药学 >> 临床医学 提交时间： 2020-02-28
Zikuan Leng
Rongjia Zhu
Wei Hou
Yingmei Feng
Yanlei Yang
Qin Han
Guangliang Shan
Fanyan Meng
Dongshu Du
Shihua Wang
Junfen Fan
Wenjing Wang
Luchan Deng
Hongbo Shi
Hongjun Li
Zhongjie Hu
Fengchun Zhang
Jinming Gao
Hongjian Liu
Xiaoxia Li
摘要： A coronavirus (HCoV-19) has caused the novel coronavirus disease (COVID-19) outbreak in Wuhan, China, Preventing and reversing the cytokine storm may be the key to save the patients with severe COVID-19 pneumonia. Mesenchymal stem cells (MSCs) have been shown to possess a comprehensive powerful immunomodulatory function. This study aims to investigate whether MSC transplantation improve the outcome of 7 enrolled patients with COVID-19 pneumonia in Beijing YouAn Hospital, China from Jan 23, 2020. to Feb 16, 2020. The clinical outcomes, as well as changes of inflammatory and immune function levels and adverse effects of 7 enrolled patients were assessed for 14 days after MSC injection. MSCs could cure or significantly improve the functional outcomes of seven patients with COVID-19 pneumonia in 14 days without observed adverse effect. The pulmonary function and symptoms of all patients with COVID-19 pneumonia were significantly improved in 2 days after MSC transplantation. Among them, two common and one severe patient were recovered and discharged in 10 days after treatment. After treatment, the peripheral lymphocytes were increased and the overactivated cytokine-secreting immune cells CXCR3 CD4 T cells, CXCR3 CD8 T cells, and CXCR3 NK cells were disappeared in 3-6 days. And a group of CD14 CD11c CD11bmid regulatory DC cell population dramatically increased. Meanwhile, the level TNF-α is significantly decreased while IL-10 increased in MSC treatment group compared to the placebo control group. Furthermore, the gene expression profile showed MSCs were ACE2- and TMPRSS2- which indicated MSCs are free from COVID-19 infection. Thus, the intravenous transplantation of MSCs was safe and effective for treatment in patients with COVID-19 pneumonia, especially for the patients in critically severe condition.
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