Subjects: Medicine, Pharmacy >> Clinical Medicine submitted time 2024-02-20 Cooperative journals: 《中国全科医学》
Abstract： Background Cardiovascular disease（CVD）is the leading cause of death in China and the world as a whole，and lipid metabolism disorder is the key factor for this disease. A comprehensive understanding of the prevalence of dyslipidemia in children and adolescents can contribute to the early prevention of dyslipidemia in adulthood. Objective To systematically evaluate the status quo of the prevalence of dyslipidemia in Chinese children and adolescents. Methods Cross#2;sectional studies on the morbidity rate of dyslipidemia among Chinese children and adolescents and published from 2015 to July 2023 were retrieved from databases of CBM，CNKI，Wanfang，VIP，Embase，Web of Science and The Cochrane Library. Processes of literature screening，data extraction and risk bias analysis were performed by two researchers. A meta-analysis was performed by taking advantage of Stata 17.0. Results 34 cross-sectional studies were collected and a total of 134438 children and adolescents were involved. Results of the meta-analysis indicated that the overall morbidity rate of dyslipidemia in Chinese children and adolescents was 19%（95%CI=16%-21%），and the morbidity rates of high cholesterol（TC），high triacylglycerol（TG），high low-density lipoprotein cholesterol（LDL-C），low high-density lipoprotein cholesterol（HDL-C） were 6%（95%CI=5%-7%），9%（95%CI=6%-12%），4%（95%CI=3%-5%）and 10%（95%CI=7%-13%）respectively. Regarding time distribution，the detection rate of dyslipidemia was fluctuant and showed a decreasing trend； the detection rate of high TC and high LDL-C showed an increasing trend in general，but it fell slightly in 2023； the detection rate of high TG and low HDL-C fluctuated greatly： the detection rate of high TG gradually decreased from 2018 to 2022 and rebounded slightly in 2023. The results of subgroup analysis showed that，concerning age，the overall morbidity rate of dyslipidemia in children and adolescents and that of high TC showed an ascending tendency with the increasing of age（10% and 2% for those aged from 3 to 6，17% and 10% for those aged from 7 to 11，and 27% and 14% for those aged from 12 to18），the morbidity rate of lowered HDL-C was higher among 12-to-18-year olds（21%）than among 7-to-11-year olds（9%），and the morbidity rate of high TC among 3-to-6-year olds（9%）was higher than that among 7-to-11-year olds and 12-to-18-year-olds（4% and 3%）. Concerning region，the morbidity rates of high TG and low HDL-C were higher in the West（15% and 5%）than those in the East（5% and 7%），and the morbidity rates of high TC and high LDL-C were higher in the East（7% and 6%）than in the West（3% and 2%）. Concerning BMI，the morbidity rates of dyslipidemia，high TG and high LDL-C were higher in obese children and adolescents （48%，18%，25%，and 7%）than in overweight（27%，6%，9%，and 4%）and normal children and adolescents（15%， 4%，3%，and 3%）. Conclusion The morbidity rate of dyslipidemia in Chinese children and adolescents is relatively high and varied across the age，region and BMI of children and adolescents. Due to the limitation of the number and quality of included studies，more high-quality studies are needed to be conducted to further validate these findings.
Subjects: Biology >> Zoology submitted time 2017-11-07 Cooperative journals: 《动物营养学报》
Abstract：本试验旨在研究饲粮中添加不同水平胡芦巴粉对肉仔鸡生长性能、肉品质、免疫器官指数及血清抗氧化和生化指标的影响。试验选用1日龄爱拔益加肉仔鸡320只，随机分为4个组，每组8个重复，每个重复10只鸡。各组分别饲喂含0（对照）、3%、6%、9%胡芦巴粉的营养水平相同的全价饲粮，试验期42 d。结果表明：1）1~21日龄，6%和9%胡芦巴粉组平均体重和平均日增重显著低于对照组（P0.05）。2）9%胡芦巴粉组胸肌滴水损失率和压力损失率显著低于对照组（P0.05）。3）6%胡芦巴粉组21日龄脾脏指数显著高于对照组（P0.05）。4）9%胡芦巴粉组的21日龄血清总超氧化物歧化酶活性高于对照组（P>0.05），且显著高于3%和6%胡芦巴粉组（P0.05）。5）9%胡芦巴粉组的21日龄血清谷草转氨酶活性显著高于对照组（P0.05）。由此可见，胡芦巴粉可作为一种蛋白质饲料原料应用于肉仔鸡生产，其具有提高肌肉系水力，促进免疫器官发育，提高抗氧化能力和增强机体蛋白质代谢的作用。胡芦巴粉在肉仔鸡饲粮中的适宜添加水平为：1~21日龄不超过3%，22~42日龄不超过6%。
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