分类: 光学 >> 量子光学 提交时间: 2023-02-19
摘要: Topological photonics and its topological edge state which can suppress scattering and immune defects set off a research boom. Recently, the quantum valley Hall effect (QVHE) with large valley Chern number and its multimode topological transmission have been realized, which greatly improve the mode density of the topological waveguide and its coupling efficiency with other photonic devices. The multifrequency QVHE and its topological transmission have been realized to increase the transmission capacity of topological waveguide, but multifrequency and multimode QVHE have not been realized simultaneously. In this Letter, the valley photonic crystal (VPC) is constructed with the Stampfli-triangle photonic crystal (STPC), and its degeneracies in the low-frequency and high-frequency bands are broken simultaneously to realize the multifrequency and multimode QVHE. The multifrequency and multimode topological transmission is realized through the U-shaped waveguide constructed with two VPCs with opposite valley Chern numbers. According to the bulk-edge correspondence principle, the Chern number is equal to the number of topological edge states or topological waveguide modes. Therefore, we can determine the valley Chern number of the VPC by the number of topological edge states or topological waveguide modes, further determine the realization of large valley Chern number. These results provide new ideas for high-efficiency and high-capacity optical transmission and communication devices and their integration, and broaden the application range of topological edge states.
分类: 医学、药学 >> 临床医学 分类: 生物学 >> 遗传学 提交时间: 2020-03-06
摘要: Germline polymorphisms have been linked with differential survival outcomes in cancers but have not been well studied in nasopharyngeal carcinoma (NPC). Here, two-phase association study is conducted to discover germline polymorphisms that are associated with the prognosis of NPC. The discovery phase includes two consecutive hospital cohorts of patients with NPC from Southern China. Exome-wide genotypes at 246,173 single nucleotide polymorphisms (SNPs) are determined, followed by survival analysis for each SNP under Cox proportional hazards regression model. Candidate SNP is replicated in another two independent cohorts from Southern China and Singapore. Meta-analysis of all samples (n = 5,553) confirm that the presence of rs1131636-T, located in the 3′-UTR of RPA1, confers an inferior overall survival (HR = 1.33, 95% CI = 1.20-1.47, P = 6.31 × 10-8). Bioinformatics and biological assays show that rs1131636 has regulatory effects on upstream RPA1. Functional studies further demonstrate that RPA1 promoted the growth, invasion, migration, and radioresistance of NPC cells. Additionally, miR-1253 has been identified as a suppressor for RPA1 expression, likely through regulation of its binding affinity to rs1131636 locus. Collectively, these findings provide a promising biomarker aiding in stratifying patients with poor survival, as well as a potential drug target for NPC.