Subjects: Library Science，Information Science >> Information Science submitted time 2024-05-08
Abstract： Purpose/Significance This paper starts from the field of humanities and social sciences, and compares the model performance of humanities and social sciences from the aspects of basic knowledge and academic texts of humanities and social sciences. It aims to provide a systematic large language model evaluation benchmark for the field of humanities and social sciences for the reference of researchers in humanities and social sciences related fields. Methods/Processes Seven evaluation tasks related to the field of humanities and social sciences were designed and corresponding indicators were selected. On this basis, the current open-source and high-performance general-purpose domain Chinese large language models were selected to complete the domain-specific tasks in the form of questions and answers by invoking the local models, and their performance in the field of humanities and social sciences was quantitatively evaluated by selecting relevant indicators. Results/Conclusions The evaluation results show that among the open-source models selected in this paper, Qwen has the best performance, followed by Baichuan2, InternLM, and Atom is the worst performer in both the base model and the dialog model; moreover, in most cases, the dialog model shows more superior performance compared to the base model.
Subjects: Biology >> Bioengineering submitted time 2019-01-17 Cooperative journals: 《中国生物工程杂志》
Abstract：环氧化物水解酶能够对外消旋环氧化物进行动力学拆分保留单构型的环氧化物。测定了菜豆环氧化物水解酶 (PvEH1) 针对苯基缩水甘油醚及其甲基衍生物的催化特性，并基于分子对接及多序列比对分析确定7个突变位点，通过单点和组合突变对PvEH1进行改造，以期改善PvEH1对邻甲基苯基缩水甘油醚 (1a) 的催化特性。底物谱分析表明PvEH1对1a的催化活性 (157.2 U/g湿细胞) 和对映选择性 (E = 5.6) 最高。单点突变结果显示E. coli/pveh1L105I和E. coli/pveh1V106I对1a的催化活性和对映选择性均有明显提高；L105I和V106I位组合突变菌株E. coli/pveh1L105I/V106I的催化活性 (493.8 U/g湿细胞) 是E. coli/pveh1的3.1倍，对映选择性 (E = 8.3) 也提高至E. coli/pveh1的1.5倍。纯化后PvEH1L105I/V106I的催化活性为17.6 U/mg是PvEH1的1.5倍，对1a的催化效率提高至PvEH1的2.1倍。SDS-PAGE分析表明提高了蛋白的可溶性表达量。利用E. coli/pveh1L105I/V106I全细胞催化100 mmol/L 1a水解动力学拆分获得手性纯 (R)-1a (ee > 96%) 的产率和时空产率分别为31.2%和5.12 g/L/h，因此，在手性纯 (R)-1a的制备中，E. coli/pveh1L105I/V106I是一种颇具潜力的生物催化剂。
Subjects: Psychology >> Cognitive Psychology submitted time 2018-09-07 Cooperative journals: 《心理学报》
Abstract： 研究采用注意网络测验任务(attention network test, ANT), 分别检验自我相关信息在注意的警觉、定向和执行控制网络上的加工效率差异, 以揭示自我信息识别优势的注意机制。实验1考察了面孔类型(自我面孔或他人面孔)在3种注意网络下的加工效率差异; 实验2采用自我联结学习范式对实验1进行验证; 实验3将颜色类型(红色或绿色)作为目标刺激, 面孔类型作为背景, 以考察任务无关自我信息是否对注意网络加工效率有影响。研究结果发现, 当自我信息为目标时, 个体在注意定向网络上存在加工效率优势, 而警觉和执行控制网络上没有加工效率差异。当自我相关信息与任务无关时, 在注意的警觉、定向和执行控制网络中均未表现出加工效率优势。说明了自我信息的注意优势发生在注意定向网络上, 且受任务优先性影响。
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