Subjects: Medicine, Pharmacy >> Preventive Medicine and Hygienics submitted time 2023-11-01 Cooperative journals: 《中国全科医学》
Abstract： Background With the accelerated aging of the national population，the rapid increase of the elderly with dementia has become an increasingly prominent problem. Sleep is the basic need of the human body，and sleep problems have become an independent risk factor for the cognitive function of the elderly. Moderate sleep duration is essential for the removal of brain wastes，synaptic plasticity，and the maintenance of normal function of the nervous system. However，the current sleep problems of the elderly have not attracted widespread attention，and the sleep time of the elderly needs to be further studied. Objective To explore the dose-response relationship between sleep duration and risk of senile dementia. Methods CNKI，Wanfang Data，VIP，CBM，PubMed，Cochrane Library，Embase and Web of Science databases were searched for prospective cohort studies on the relationship between sleep duration and risk of senile dementia from inception to June 2023. Literature data were independently extracted by two researchers，and literature quality evaluation was performed. Dose-response meta-analysis was performed by applying restricted cubic spline regression model in Stata 16.0 software. Results A total of 9 papers with 58342 study subjects and 9 887 exposures were included. Meta-analysis showed that sleep duration was associated with the risk of senile dementia［RR=1.32，95%CI（1.17-1.48），P<0.05］. The results of the subgroup analysis showed that the risk of senile dementia was increased by 19.2% in those with ≤ 6 h of sleep［RR=1.19，95% CI （1.07-1.33），P<0.05］；sleeping duration ≥ 8 h increases the risk of senile dementia by 55.02%［RR=1.55，95%CI（1.32-1.82），P<0.05］. Dose-response meta-analysis results showed a U-shaped nonlinear relationship between sleep duration and risk of senile dementia（P<0.001）. Compared with the reference sleep duration of 7 h，the risk of morbidity at each time point was as follows 5 h：RR=1.024，95%CI=0.928-1.130；5.5 h：RR=1.036，95%CI=0.938-1.143；6 h：RR=1.034，95%CI=0.952-1.124；6.5 h：RR=1.015，95%CI=0.973-1.059；7.5 h：RR=1.014，95%CI=0.993-1.035；8 h：RR=1.056，95%CI=1.023-1.091；8.5 h：RR=1.124，95%CI=1.062-1.190；9 h：RR=1.212，95%CI=1.098-1.338；9.5 h：RR=1.316，95%CI=1.133-1.528；10 h：RR=1.431，95%CI=1.169-1.752. Conclusion There is a U-shaped nonlinear dose-response relationship between sleep duration and the risk of senile dementia，and the daily sleep duration ≥ 8 h will increase the risk of senile dementia.
Subjects: Other Disciplines >> Synthetic discipline submitted time 2023-03-28 Cooperative journals: 《中国科学院院刊》
Abstract： Biosafety is an essential part of the national security system, which is related to people’s lives and health, the country’s long#2;term stability, and sustainable development, which is the bottom line that must be guaranteed. The international biosafety situation is grim and complex, while domestic biosafety faces challenges. Therefore, biosafety capacity building has become an international hot spot, among which scientific and technological innovation, talent training, and infrastructure platform construction are the top priorities. Although China has achieved strategic results in the rapid identification of pathogens, research, and development of specific vaccines and medicine in fighting against COVID-19 by relying on scientific research, it has shown the urgency for scientific and technological innovation in biosafety. Therefore, China has developed a strategic plan on“promoting the modernization of the national security system and capabilities, resolutely safeguarding national security and social stability” included in the 20th National Congress of the Communist Party of China. Hence, it is suggested to promote biosafety capacity building further to improve China’s biosecurity system, protect people’s health, ensure national security, and maintain long-term peace and stability by improving the layout of scientific and technological frontiers, promoting the construction of biosafety discipline, training of more special talents, and infrastructure platform construction.
Subjects: Biology >> Zoology submitted time 2017-11-08 Cooperative journals: 《动物营养学报》
Abstract：为探究异地育肥牦牛模式，本试验对比了本地杂交肉牛（秦川×西门塔尔）在同等条件下血液生理生化指标和生长性能的差异
Subjects: Biology >> Zoology submitted time 2017-10-10 Cooperative journals: 《动物营养学报》
Abstract：本试验旨在研究不同增钙模式对蛋鸡生产性能、胫骨质量以及血清相关生化指标的影响，以确定蛋鸡生产过程中饲粮钙的增加模式以及钙的添加量。选取18周龄海兰灰商品蛋鸡480只，随机分为4组，每组4个重复，每个重复30只。增钙时间点分别为18周龄以及产蛋率为5%、50%和90%时，各时间点增钙方式分别为：Ⅰ组2.00%、2.20%、2.40%和3.75%；Ⅱ组2.00%、2.50%、3.00%和3.75%；Ⅲ组2.00%、3.00%、3.75%和3.75%；Ⅳ组2.00%、3.75%、3.75%和3.75%。试验期9周。结果表明：1）Ⅲ组蛋鸡产蛋率显著高于Ⅰ组和Ⅳ组（P0.05）；2）Ⅲ组胫骨强度、胫骨重、胫骨钙含量显著高于Ⅰ组和Ⅱ组（P0.05）；3）蛋鸡产蛋率达50%时，Ⅰ组和Ⅱ组血钙含量显著高于Ⅲ组和Ⅳ组（P0.05）。结果提示：当蛋鸡产蛋率达5%、50%和90%时，饲粮钙水平分别为3.00%、3.75%和3.75%有助于提高蛋鸡产蛋率，改善体况和稳定骨骼质量，同时不造成钙源浪费。
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