Disease Burden and Variation Tendency of Inflammatory Bowel Disease in China from 1990 to 2019

Subjects: Medicine, Pharmacy >> Clinical Medicine submitted time 2023-07-21 Cooperative journals: 《中国全科医学》

BAO Yunli WANG Zhe TANG Hairu LI Na ZHENG Ying LI Bin MA Jun YU Xiaohui

Abstract： Background　Inflammatory bowel disease（IBD） has become highly prevalent in recent years characterized by a prolonged disease course and high disease burden. However，there is a lack of data to understand the burden of IBD in China，which may hinder health care planning and resource allocation for the disease. Objective　To investigate the burden of IBD and its variation tendency in China from 1990 to 2019，and analyze the influence of age，gender and period on IBD. Methods　The incidence，mortality and disability adjusted life year（DALY） rate of IBD in China from 1990 to 2019 were collected using the Global Burden of Disease Database 2019. Joinpoint software was used to analyze the variation tendency and characteristics of standardized incidence，standardized mortality and standardized DALY rate of IBD，and Excel 2019software was used for data processing. Results　From 1990 to 2019，the standardized incidence increased from 1.47 per 100 000 to 3.001 per 100 000 with AAPC of 2.50%〔95%CI（2.4，2.6）〕，the standardized mortality decreased from 0.86/100 000 to 0.35/100 000 with AAPC of -1.6%〔95%CI（-3.8，-3.4）〕，the standardized DALY rate decreased from 24.47/100 000 to 16.31/100 000，with AAPC of -2.20% （95%CI：-2.3，-2.0），the changes of trends were all statistically significant（P<0.05）. The standardized incidence and mortalityof of males were higher than females in each year，while the standardized DALY rate of females was higher than males before 1995，basically the same in males and females from 1995 to 2001，and higher in males than females after 2001. There was overall stable uptrend in the AAPC of the standardized incidence of IBD in all age groups by year（P<0.05） and overall downtrend in the AAPC of standardized mortality rate in all age groups，while the downtrend became slower with increasing age（P<0.05）. Conclusion　From 1990 to 2019，the standardized mortality rate and DALY rate of IBD showed a downtrend，while the standardized incidence showed an uptrend. The standardized incidence and mortality of males were higher than females by year. The burden of IBD in elderly population deserves priority attention and will be a major public health challenge in China due to large population base and aging population. 

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