Subjects: Medicine, Pharmacy >> Preventive Medicine and Hygienics submitted time 2023-12-11 Cooperative journals: 《中国全科医学》
Abstract： Ischemic stroke is the most common cerebrovascular accident and is increasingly becoming a serious global health problem. Mitochondrial quality control disorder is an important mechanism of neuronal death induced by cerebral ischemia，and the maintenance of mitochondrial function is essential for promoting neuronal survival and improving neurological function. Mitochondrial quality control mainly involves mitochondrial oxidative stress，mitochondrial dynamics，mitochondrial autophagy，mitochondrial biogenesis，etc.，which is an important condition for stabilizing the normal structure of mitochondria and exerting the normal function of mitochondria. In recent years，traditional Chinese medicine（TCM） has significantly improved the clinical symptoms of patients with ischemic stroke by affecting the structure and function of mitochondria through multi-perspective，multi-pathway，multi-target regulation of mitochondrial quality control，which has received extensive attention from scholars. This article summarizes the experimental studies and clinical observations on the application of effective compound components of TCM and TCM compound to regulate mitochondrial quality control in the treatment of ischemic stroke in recent years，further explains the pathogenesis of ischemic stroke，clarifies the regulatory mechanism of TCM on mitochondrial quality control，and summarizes the scientific connotation and shortcomings of TCM in the treatment of ischemic stroke，in order to provide ideas and methods for further clinical application of TCM in the treatment of ischemic stroke.
Subjects: Medicine, Pharmacy >> Preventive Medicine and Hygienics submitted time 2023-11-03 Cooperative journals: 《中国全科医学》
Abstract： Background The prevalence of dyslipidemia among adults in China reached 40.4% in 2012，and dyslipidemia is an independent risk factor for atherosclerotic cardiovascular diseases（ASCVD），and the elderly are at high risk for dyslipidemia and chronic diseases. The results of the previous survey showed that the prevalence of dyslipidemia among the elderly in the Malu district of Shanghai was 63%，therefore，it is of great significance to control dyslipidemia effectively. Objective To explore the synergistic effect of using acupoint catgut embedding combined with atorvastatin calcium to intervene in hyperlipidemia among the elderly in Malu district，so as to provide a basis for preventing and treating hyperlipidemia in the elderly and guide clinical practice. Methods As a single-center randomized controlled trial，a total of 120 elderly patients with hyperlipidemia recruited in the outpatient clinic of Malu Community Health Service Center of Jiading District from 2020-05-10 to 2020-08-04 were randomly divided into the treatment（n=59） and control groups（n=60） in a 1 ∶ 1 ratio by using simple random digit grouping methods. The treatment group was treated with acupoint catgut embedding combined with atorvastatin calcium，and the embedding was performed once every 2 weeks，4 times for a course of treatment，while taking 10 mg of oral atorvastatin calcium tablets daily; the control group received only 10 mg of oral atorvastatin calcium tablets daily for 8 weeks of the intervention cycle. The main observational indexes were LDL cholesterol compliance and improvement in lipid levels，and the effect of this treatment regimen in different populations were explored. Results The primary outcome indicators included that the LDL cholesterol compliance rates were 79.5% and 71.4% in the two groups after treatment，respectively; there was no significant difference in the comparison of total cholesterol，triglycerides，low density lipoprotein cholesterol and high density lipoprotein cholesterol before and after treatment and 1 month of follow-up in the two groups（P>0.05）. The secondary outcome indicators included that there was no significant difference in the comparison of apolipoprotein A ，apolipoprotein B ，lipoprotein alpha，fasting blood glucose and glycated albumin before and after treatment between the two groups（P>0.05），the comparison of the difference of BMI in the two groups before and after treatment，after treatment，and 1 month follow-up showed no statistically significant difference（P>0.05）;the TCM evidence scores of the treatment group were higher than those of the control group after treatment（P<0.001）. The adverse reactions included that the rate of abnormal elevation of glutamyl transfer in the treatment group was lower than that in the control group（P<0.05）. Conclusion The combination of acupoint catgut embedding with atorvastatin calcium improves lipid levels in the elderly with advantages in improving the TCM evidence scores and reducing the adverse effects of atorvastatin calcium.
Subjects: Physics >> General Physics: Statistical and Quantum Mechanics, Quantum Information, etc. submitted time 2023-08-29 Cooperative journals: 《中国全科医学》
Abstract： Background Cardiovascular disease is a major chronic disease that seriously endangers human health，and remains a public health problem to be solved in China and even globally. Objective To explore the epidemic characteristics and disease burden of cardiovascular diseases in China from 1990 to 2019，forecast the incidence of cardiovascular diseases in China from 2020 to 2050，and provide a reference for the formulation of relevant prevention and treatment strategies of cardiovascular diseases. Methods The 2019 Global Burden of Disease Study （GBD 2019） database was searched to extract and analyze relevant data on cardiovascular disease burden and risk factors in China and globally from 1990 to 2019. The prevalence of cardiovascular diseases was quantified by using the publicly available incidence，prevalence，mortality， and corresponding age-standardized rate（referred to as standardized rate） based on GBD 2019 database，and the burden of diseases was quantified by years lived with disability（YLD），years of life lost（YLL） and disability adjusted life year（DALY），and the ARIMA model was constructed to predict the incidence of cardiovascular diseases in China from 2020 to 2050. Results Compared with 1990，the incidence，prevalence and mortality of cardiovascular diseases in China showed an increasing trend by year up to 2019，in which the incidence，prevalence and mortality increased by 93.75%，99.75% and 57.39%，respectively. The standardized incidence and prevalence of females were higher than those of males，while the standardized mortality was lower than that of males. According to the data in 2019，the overall incidence of cardiovascular diseases in China showed an increasing trend with age，reaching its highest value in the age group of 95 years and above. Incidence trends for both men and women were similar to the overall trend，with slight differences. The overall prevalence also increases with age and is higher in women than men. There is an increasing trend in cardiovascular disease mortality after the age of 45，with males having a higher mortality rate than females at all ages. Compared with 1990，the rates of YLL，YLD and DALY in Chinese men increased by 36.99%，102.42% and 40.78%，respectively，and increased by 2.79%，107.13% and 11.50% in women. According to the data in 2019，the YLL rate，YLD rate and DALY rate of cardiovascular diseases in Chinese population showed an upward trend with the increase of age，with no inflection point. YLL rate and DALY rate of males gradually increased with the progress of population aging and were much higher than females，YLD rate gradually increased in the the age group of 55-59 years and was much higher than males. From 1990 to 2019，the global standardized incidence，standardized prevalence and standardized mortality of cardiovascular diseases showed a downward trend by year，while the standardized morbidity and standardized morbidity still increased in China，the standardized incidence and prevalence decreased，but that was still higher than the global scale. From the global level，the standardized YLL rate and DALY rate of cardiovascular diseases in China showed a downward trend along with the global level，but the disease burden of cardiovascular diseases in China was higher than the global level after 2000，and the standardized YLD rate increased by year. Risk factors associated with death from cardiovascular diseases mainly included smoking，second-hand smoke，alcohol consumption，low physical activity，high fasting blood glucose，high systolic blood pressure，high BMI，high low density lipoprotein cholesterol and renal insufficiency. From the relevant data in China and globally，high systolic blood pressure （hypertension） was still the primary risk factor for death from cardiovascular diseases，and the number of deaths was increasing by year. High density lipoprotein cholesterol （hyperlipidemia） was the second cause of death from cardiovascular diseases globally and in China in recent years. From 2020 to 2050，the standardized incidence of cardiovascular diseases in China is still on the rise，and it is expected that the standardized incidence of cardiovascular diseases will reach 663.618 per 100 000 by 2050. Conclusion The incidence，prevalence and mortality of cardiovascular diseases in China from 1990 to 2019 have shown an increasing trend by year. The disease burden caused by cardiovascular diseases is more severely，and there is no inflection point in the next 50 years. The prevalence and burden of diseases are higher than those of the world. It is expected that the standardized incidence of cardiovascular diseases will reach 663.618 per 100 000 by 2050.
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