Subjects: Biology >> Ecology submitted time 2024-08-14 Cooperative journals: 《干旱区科学》
Abstract: Understanding the response of vegetation variation to climate change and human activities is critical for addressing future conflicts between humans and the environment, and maintaining ecosystem stability. Here, we aimed to identify the determining factors of vegetation variation and explore the sensitivity of vegetation to temperature (SVT) and the sensitivity of vegetation to precipitation (SVP) in the Shiyang River Basin (SYRB) of China during 2001–2022. The climate data from climatic research unit (CRU), vegetation index data from Moderate Resolution Imaging Spectroradiometer (MODIS), and land use data from Landsat images were used to analyze the spatial-temporal changes in vegetation indices, climate, and land use in the SYRB and its sub-basins (i.e., upstream, midstream, and downstream basins) during 2001–2022. Linear regression analysis and correlation analysis were used to explore the SVT and SVP, revealing the driving factors of vegetation variation. Significant increasing trends (P<0.05) were detected for the enhanced vegetation index (EVI) and normalized difference vegetation index (NDVI) in the SYRB during 2001–2022, with most regions (84%) experiencing significant variation in vegetation, and land use change was determined as the dominant factor of vegetation variation. Non-significant decreasing trends were detected in the SVT and SVP of the SYRB during 2001–2022. There were spatial differences in vegetation variation, SVT, and SVP. Although NDVI and EVI exhibited increasing trends in the upstream, midstream, and downstream basins, the change slope in the downstream basin was lower than those in the upstream and midstream basins, the SVT in the upstream basin was higher than those in the midstream and downstream basins, and the SVP in the downstream basin was lower than those in the upstream and midstream basins. Temperature and precipitation changes controlled vegetation variation in the upstream and midstream basins while human activities (land use change) dominated vegetation variation in the downstream basin. We concluded that there is a spatial heterogeneity in the response of vegetation variation to climate change and human activities across different sub-basins of the SYRB. These findings can enhance our understanding of the relationship among vegetation variation, climate change, and human activities, and provide a reference for addressing future conflicts between humans and the environment in the arid inland river basins.
Subjects: Agriculture, Forestry,Livestock & Aquatic Products Science >> Soil Science submitted time 2024-07-31 Cooperative journals: 《干旱区科学》
Abstract: Soil salinization may affect biodiversity and species composition, leading to changes in the plant community structure. However, few studies have explored the spatial pattern of soil salinization and its effects on shrub community structure at the ecosystem scale. Therefore, we conducted a transect sampling of desert shrublands in Northwest China during the growing season (June–September) in 2021. Soil salinization (both the degree and type), shrub community structure (e.g., shrub density and height), and biodiversity parameters (e.g., Simpson diversity, Margalf abundance, Shannon-Wiener diversity, and Pielou evenness indices) were used to assess the effects of soil salinization on shrub community structure. The results showed that the primary degree of soil salinization in the study area was light salinization, with the area proportion of 69.8%. Whereas the main type of soil salinization was characterized as sulfate saline soil, also accounting for 69.8% of the total area. Notably, there was a significant reduction in the degree of soil salinization and a shift in the type of soil salinization from chloride saline soil to sulfate saline soil, with an increase in longitude. Regional mean annual precipitation (MAP), mean annual evapotranspiration (MAE), elevation, and slope significantly contributed to soil salinization and its geochemical differentiation. As soil salinization intensified, shrub community structure displayed increased diversity and evenness, as indicated by the increases in the Simpson diversity, Shannon-Wiener diversity, and Pielou evenness indices. Moreover, the succulent stems and leaves of Chenopodiaceae and Tamaricaceae exhibited clear advantages under these conditions. Furthermore, regional climate and topography, such as MAP, MAE, and elevation, had greater effects on the distribution of shrub plants than soil salinization. These results provide a reference for the origin and pattern of soil salinization in drylands and their effects on the community structure of halophyte shrub species.
Subjects: Nuclear Science and Technology >> Particle Accelerator submitted time 2024-07-01
Abstract: A compact 10 MeV S-band irradiation electron linear accelerator (linac) was developed to simulate electronic radiation in outer space and perform electron irradiation effect tests on spacecraft materials and devices. According to the requirements of space environment simulation, the electron beam energy can be adjusted in the range from 3.5 MeV to 10 MeV, and the average current can be adjusted in the range from 0.1 mA to 1 mA. The linac should be capable of providing beam irradiation over a large area of 1 m² with a uniformity greater than 90% and a scanning rate of 100 Hz. A novel method was applied to achieve such a high beam scanning rate by combining a kicker and a scanning magnet. Based on this requirement, a design for the 10 MeV linac is proposed with an RF power pulse repetition rate of 500 Hz ; it includes a thermal cathode electron gun, a bunching-accelerating section, and a scanning transport line. The detailed physical design and dynamic simulation results of the proposed 10 MeV electron linac are presented in this paper.
Subjects: Pharmaceutical Science >> Biochemistry(Drug related) submitted time 2024-06-14
Abstract: Gemcitabine (GEM) is a potent chemotherapeutic agent widely employed in the treatment of various cancers, notably pancreatic cancer. Despite its clinical success, challenges related to GEM resistance and toxicity persist. Therefore, there is a pressing need for a deeper understanding of its intracellular mechanisms and potential targets. In this study, we utilized quantitative proteomics and thermal proteome profiling (TPP) to elucidate the effects of GEM. Our proteomic analysis revealed that GEM primarily affected DNA synthesis, leading to the upregulation of cell cycle and DNA replication proteins. Additionally, enrichment analysis highlighted the activation of the p53 pathway, shedding light on GEM-induced apoptosis mechanisms. Notably, we observed the upregulation S-phase kinase-associated protein 2 (SKP2), a cell cycle and chemoresistance regulator, in response to GEM treatment. Combining SKP2 inhibition with GEM showed synergistic effects in both cellular and animal models, suggesting SKP2 as a potential target for enhancing GEM sensitivity and overcoming chemoresistance. Furthermore, through TPP, we explored potential binding targets of GEM, which implies GEM’s broad anticancer effects. Together, these findings provide valuable insights into GEM’s molecular mechanisms and offer potential targets for improving treatment efficacy. This research holds the promise of advancing personalized treatment strategies and opening avenues for novel combination therapies to enhance outcomes in pancreatic cancer.
Subjects: Astronomy >> Astronomical Instruments and Techniques submitted time 2024-06-06 Cooperative journals: 《天文技术与仪器(英文)》
Abstract: The reconstruction of muon energies is crucial for the data analysis of neutrino experiments using large water Cherenkov detectors, but the resolution for muon energy reconstruction using traditional methods is poor. Here, we propose a revised approach to remove noisy optical modules along the track produced by the propagation of muons through water. The number of photons on the optical modules is first corrected by the attenuation properties of light in water. Then the difference in time between the observed optical modules and the expected ones is determined based on the geometry of the triggered optical modules. Finally, the standard of correction is measured by the ratio of photon number before and after correction. Optical modules selection conditions were optimized according to these parameters, with most noisy optical modules successfully removed, improving the resolution of muon energy reconstruction.
Subjects: Astronomy >> Astronomical Instruments and Techniques submitted time 2024-06-06 Cooperative journals: 《天文技术与仪器(英文)》
Abstract: The primary mirrors of current and future large telescopes always employ a segmented mirror configuration. The small but non-negligible gaps between neighboring segments cause additional diffraction, which restricts the performance of high-contrast coronagraph. To solve this problem, we propose a coronagraph system based on a single liquid crystal spatial light modulator (SLM). This spatial light modulator is used for amplitude apodization, and its feasibility and potential performance are demonstrated using a laboratory setup using the stochastic parallel gradient descent (SPGD) algorithm to control the spatial light modulator, which is based on point spread function (PSF) sensing and evaluation and optimized for maximum contrast in the discovery working area as a merit function. The system delivers a contrast in the order of 10−6, and shows excellent potential to be used in current and future large aperture telescopes, both on the ground and in space.
Subjects: Astronomy >> Astronomical Instruments and Techniques submitted time 2024-06-06 Cooperative journals: 《天文技术与仪器(英文)》
Abstract: Research on adaptive deformable mirror technology for voice coil actuators (VCAs) is an important trend in the development of large ground-based telescopes. A voice coil adaptive deformable mirror contains a large number of actuators, and there are problems with structural coupling and large temperature increases in their internal coils. Additionally, parameters of the traditional proportional integral derivative (PID) control cannot be adjusted in real-time to adapt to system changes. These problems can be addressed by introducing fuzzy control methods. A table lookup method is adopted to replace real-time calculations of the regular fuzzy controller during the control process, and a prototype platform has been established to verify the effectiveness and robustness of this process. Experimental tests compare the control performance of traditional and fuzzy proportional integral derivative (Fuzzy-PID) controllers, showing that, in system step response tests, the fuzzy control system reduces rise time by 20.25%, decreases overshoot by 78.24%, and shortens settling time by 67.59%. In disturbance rejection experiments, fuzzy control achieves a 46.09% reduction in the maximum deviation, indicating stronger robustness. The Fuzzy-PID controller, based on table lookup, outperforms the standard controller significantly, showing excellent potential for enhancing the dynamic performance and disturbance rejection capability of the voice coil motor actuator system.
Subjects: Nuclear Science and Technology >> Radiation Physics and Technology submitted time 2024-05-30
Abstract: Cone-beam computed tomography (CBCT) is mostly used for position verification during the treatment pro#2;
cess. However, severe image artifacts in CBCT hinder its direct use in dose calculation and adaptive radiation
therapy re-planning for proton therapy. In this study, an improved U-Net neural network named CBAM-U-Net
was proposed for CBCT noise reduction in proton therapy, which is a CBCT denoised U-Net network with con#2;
volutional block attention modules. The datasets contained 20 groups of head and neck images. The CT images
were registered to CBCT images as ground truth. The original CBCT denoised U-Net network, sCTU-Net, was
trained for model performance comparison. The synthetic CT(SCT) images generated by CBAM-U-Net and the
original sCTU-Net are called CBAM-SCT and U-Net-SCT images, respectively. The HU accuracies of the CT,
CBCT, and SCT images were compared using four metrics: mean absolute error (MAE), root mean square error
(RMSE), peak signal-to-noise ratio (PSNR), and structure similarity index measure (SSIM). The mean values of
the MAE, RMSE, PSNR, and SSIM of CBAM-SCT images were 23.80 HU, 64.63 HU, 52.27 dB, and 0.9919,
respectively, which were superior to those of the U-Net-SCT images. To evaluate dosimetric accuracy, the range
accuracy was compared for a single-energy proton beam. The γ-index pass rates of a 4 cm × 4 cm scanned
field and simple plan were calculated to compare the effects of the noise reduction capabilities of the original
U-Net and CBAM-U-Net on the dose calculation results. CBAM-U-Net reduced noise more effectively than
sCTU-Net, particularly in high-density tissues. We proposed a CBAM-U-Net model for CBCT noise reduction
in proton therapy. Owing to the excellent noise reduction capabilities of CBAM-U-Net, the proposed model
provided relatively explicit information regarding patient tissues. Moreover, it can be used in dose calculation
and adaptive treatment planning in the future.
Subjects: Geosciences >> Atmospheric Sciences submitted time 2024-05-15 Cooperative journals: 《干旱区科学》
Abstract: The desert-oasis transition zone (DOTZ) serves as a buffer area between the desert and oasis. Understanding its wind field characteristics is of great significance for the prevention and control of aeolian disasters in the oasis. In this study, we used meteorological data during 2013–2019 from the portable meteorological stations at five sites (site A on the edge of the oasis, sites B, C, and D in the DOTZ, and site O in the desert) in Dunhuang, China to analyze the near-surface wind field characteristics and their causes, as well as to reveal the key role of the DOTZ in oasis protection. The results showed that the mean wind speed, frequency of sand-driving wind, and directional variability of wind decreased from west to east within the DOTZ, and wind speed was significantly affected by air temperature. The terrain influenced the prevailing winds in the region, mainly from northeast and southwest. Only some areas adjacent to the oasis were controlled by southeasterly wind. This indicated that the near-surface wind field characteristics of the DOTZ were caused by the combined effects of local terrain and surface hydrothermal difference. At site D, the annual drift potential (DP) was 24.95 vector units (VU), indicating a low wind energy environment, and the resultant drift direction (RDD) showed obvious seasonal differences. Additionally, the DOTZ played an important buffering role between the desert and oasis. Compared with the desert, the mean wind speed in the oasis decreased by 64.98%, and the prevailing wind direction was more concentrated. The results of this study will be useful in interpreting the aeolian activity of the DOTZ in Dunhuang.
Subjects: Nuclear Science and Technology >> Other Disciplines of Nuclear Science submitted time 2024-05-08
Abstract: In this study, to efficiently remove Pb(II) from aqueous environments, a novel L-serine-modified polyethylene/polypropylene nonwoven fabric sorbent (NWF-serine) was fabricated through the radiation grafting of glycidyl methacrylate and subsequent L-serine modification. The effect of the absorbed dose was investigated in the range of 5–50 kGy. NWF-serine was characterized by Fourier transform infrared spectroscopy, thermogravimetric analysis, and scanning electron microscopy. Batch adsorption tests were conducted to investigate the influences of pH, adsorption time, temperature, initial concentration, and sorbent dosage on the Pb(II) adsorption performance of NWF-serine. The results indicated that Pb(II) adsorption onto NWF-serine was an endothermic process, following the pseudo-second-order kinetic model and Langmuir isotherm model. The saturated adsorption capacity was 198.1 mg/g. NWF-serine exhibited Pb(II) removal rates of 99.8% for aqueous solutions with initial concentrations of 100 mg/L and 82.1% for landfill leachate containing competitive metal ions such as Cd, Cu, Ni, Mn, and Zn. Furthermore, NWF-serine maintained 86% of its Pb(II) uptake after five use cycles. The coordination of the carboxyl and amino groups with Pb(II) was confirmed using X-ray photoelectron spectroscopy and extended X-ray absorption fine structure analysis.
Subjects: Physics >> Nuclear Physics submitted time 2024-04-28
Abstract: The high-intensity heavy-ion accelerator facility (HIAF) is a scientific research facility complex composed of
multiple cascade accelerators of different types, which pose a scheduling problem for devices distributed over
a certain range of 2 km, involving over a hundred devices. The White Rabbit (WR), a technology-enhancing
Gigabit Ethernet, has shown the capability of scheduling distributed timing devices but still faces the challenge
of obtaining real-time synchronization calibration parameters with high precision. This study presents a calibra#2;
tion system based on a time-to-digital converter implemented on an ARM-based System-on-Chip (SoC). The
system consists of four multi-sample delay lines, a bubble-proof encoder, an edge controller for managing data
from different channels, and a highly effective calibration module that benefits from the SoC architecture. The
performance was evaluated with an average RMS precision of 5.51 ps by measuring the time intervals from 0
to 24000 ps with 120000 data for every test. The design presented in this study refines the calibration precision
of the HIAF timing system. This eliminates the errors caused by manual calibration without efficiency loss and
provides data support for fault diagnosis. It can also be easily tailored or ported to other devices for specific
applications and provides more space for developing timing systems for particle accelerators, such as white
rabbits on HIAF.
Subjects: Pharmaceutical Science >> Structural Biology submitted time 2024-04-27
Abstract: The norepinephrine transporter (NET) plays a pivotal role in regulating neurotransmitter balance and is critical for normal physiology and neurobiology. Dysfunction of NET has been implicated in numerous neuropsychiatric diseases including depression, anxiety, attention deficit hyperactivity disorder, and Parkinson’s disease. Here we report cryo-EM structures of NET in apo and substrate-bound forms, as well as complexes with six antidepressants. The structures reveal an unexpected NET dimer interface predominantly mediated by cholesterol and lipid molecules. The substrate norepinephrine is found to bind deep within the central binding pocket, with its amine group interacting with a conserved aspartate. The structures also provide insight into antidepressant recognition, including how subtle differences in binding poses confer selectivity over other monoamine transporters. Together these breakthrough findings significantly advance our understanding of NET regulation and inhibition, providing templates for designing improved antidepressants to treat neuropsychiatric disorders.
Subjects: Astronomy >> Astronomical Instruments and Techniques submitted time 2024-04-18 Cooperative journals: 《天文技术与仪器(英文)》
Abstract: Adaptive optics (AO) is essential for high-quality ground-based observations with large telescopes because it counters the impact of wavefront aberrations caused by atmospheric turbulence. The new vacuum solar telescope(NVST) is one of the most important high-resolution solar observation instruments in the world. Three sets of solar adaptive optics systems have been developed and installed on this telescope: conventional adaptive optics, ground layer adaptive optics, and multi- conjugate adaptive optics. These have been in operation from 2018 to 2023. This paper details the development and application of solar adaptive optics on the NVST and discusses the newest instrumentation.
Subjects: Physics >> Condensed Matter: Electronic Structure, Electrical, Magnetic, and Optical Properties submitted time 2024-04-17
Abstract: The identification of new materials with superconducting properties is the pursuit in the realm of superconductivity research. Here, excitedly, we show that the simplest salt daily used can be made a superconductor at normal pressure only by adjusting its stoichiometry of Na and Cl as Na3Cl at normal pressure based on first-principles calculations. This bulk stable abnormal Na-Cl stoichiometric crystal of 3:1, the first ‘magic’ ratio, includes metallic (Na) atoms in the core as well as hybridization of ionic and metallic bonding, facilitating the electron-phonon-coupling for superconductivity with a critical temperature Tc of 0.13 K. The flat bands and van Hove singularities near the Fermi level produce large densities of states, similar to H3S and LaH10, which is beneficial for the emergence of superconductivity. The crystal composed of with abnormal Na-Cl magic stoichiometry is a precisely tunable, purely sodium and chloride-based, three-dimensional bulk superconductor, which is therefore an ideal material for designing and understanding abnormal stoichiometric crystals. The methodology of constructing this bulk abnormal crystal may be general to almost all elements, which could lead to insights into the physics of other conventional superconductors and even high-critical-temperature superconductors.
Peer Review Status:Awaiting Review
Subjects: Biology >> Botany submitted time 2024-04-15 Cooperative journals: 《干旱区科学》
Abstract: The maintenance of sand-fixing vegetation is important for the stability of artificial sand-fixing systems in which seed dispersal plays a key role. Based on field wind tunnel experiments using 11 common plant species on the southeastern edge of the Tengger Desert, China, we studied the secondary seed dispersal in the fixed and semi-fixed sand dunes as well as in the mobile dunes in order to understand the limitations of vegetation regeneration and the maintenance of its stability. Our results indicated that there were significant variations among the selected 11 plant species in the threshold of wind speed (TWS). The TWS of Caragana korshinskii was the highest among the 11 plant species, whereas that of Echinops gmelinii was the lowest. Seed morphological traits and underlying surface could generally explain the TWS. During the secondary seed dispersal processes, the proportions of seeds that did not disperse (no dispersal) and only dispersed over short distance (short-distance dispersal within the wind tunnel test section) were significantly higher than those of seeds that were buried (including lost seeds) and dispersed over long distance (long-distance dispersal beyond the wind tunnel test section). Compared with other habitats, the mobile dunes were the most difficult places for secondary seed dispersal. Buried seeds were the easiest to be found in the semi-fixed sand dunes, whereas fixed sand dunes were the best sites for seeds that dispersed over long distance. The results of linear mixed models showed that after controlling the dispersal distance, smaller and rounder seeds dispersed farther. Shape index and wind speed were the two significant influencing factors on the burial of seeds. The explanatory power of wind speed, underlying surface, and seed morphological traits on the seeds that did not disperse and dispersed over short distance was far greater than that on the seeds that were buried and dispersed over long distance, implying that the processes and mechanisms of burial and long-distance dispersal are more complex. In summary, most seeds in the study area either did not move, were buried, or dispersed over short distance, promoting local vegetation regeneration.
Subjects: Geosciences >> Atmospheric Sciences submitted time 2024-04-15 Cooperative journals: 《干旱区科学》
Abstract: Rain-on-snow (ROS) events involve rainfall on snow surfaces, and the occurrence of ROS events can exacerbate water scarcity and ecosystem vulnerability in the arid region of Northwest China (ARNC). In this study, using daily snow depth data and daily meteorological data from 68 meteorological stations provided by the China Meteorological Administration National Meteorological Information Centre, we investigated the spatiotemporal variability of ROS events in the ARNC from 1978 to 2015 and examined the factors affecting these events and possible changes of future ROS events in the ARNC. The results showed that ROS events in the ARNC mainly occurred from October to May of the following year and were largely distributed in the Qilian Mountains, Tianshan Mountains, Ili River Valley, Tacheng Prefecture, and Altay Prefecture, with the Ili River Valley, Tacheng City, and Altay Mountains exhibiting the most occurrences. Based on the intensity of ROS events, the areas with the highest risk of flooding resulting from ROS events in the ARNC were the Tianshan Mountains, Ili River Valley, Tacheng City, and Altay Mountains. The number and intensity of ROS events in the ARNC largely increased from 1978 to 2015, mainly influenced by air temperature and the number of rainfall days. However, due to the snowpack abundance in areas experiencing frequent ROS events in the ARNC, snowpack changes exerted slight impact on ROS events, which is a temporary phenomenon. Furthermore, elevation imposed lesser impact on ROS events in the ARNC than other factors. In the ARNC, the start time of rainfall and the end time of snowpack gradually advanced from the spring of the current year to the winter of the previous year, while the end time of rainfall and the start time of snowpack gradually delayed from autumn to winter. This may lead to more ROS events in winter in the future. These results could provide a sound basis for managing water resources and mitigating related disasters caused by ROS events in the ARNC.
Subjects: Physics >> Nuclear Physics submitted time 2024-03-19
Abstract: The exploration of exotic shapes and properties of atomic nuclei, e.g., α cluster and toroidal shape, is a
fascinating field in nuclear physics. To study the decay of these nuclei, a novel detector aimed at detecting
multiple alpha-particle events was designed and constructed. The detector comprises two layers of double-sided
silicon strip detectors (DSSD) and a cesium iodide scintillator array coupled with silicon photomultipliers array
as light sensors, which has the advantages of their small size, fast response, and large dynamic range. DSSDs
couple with cesium iodide crystal arrays are used to distinguish multiple alpha hits. The detector array has a
compact and integrated design that can be adapted to different experimental conditions. The detector array was
simulated using Geant4, and the excitation energy spectra of some alpha-clustering nuclei were reconstructed
to demonstrate the performance. The simulation results show that the detector array has excellent angular
and energy resolutions, enabling effective reconstruction of the nuclear excited state by multiple alpha particle
events. This detector offers a new and powerful tool for nuclear physics experiments and has the potential to
discover interesting physical phenomena related to exotic nuclear structures and their decay mechanisms
Subjects: Physics >> Nuclear Physics submitted time 2024-03-19
Abstract: In recent years, the gap between the supply and demand of medical radioisotopes has increased, necessitating new methods for producing medical radioisotopes. Photonuclear reactions based on gamma sources have unique advantages in terms of producing high specific activity and innovative medical radioisotopes. However, the lack of experimental data on reaction cross sections for photonuclear reactions of medical radioisotopes of interest has severely limited the development and production of photonuclear transmutation medical radioisotopes. In this study, the entire process of the generation, decay, and measurement of medical radioisotopes was simulated using online gamma activation and offline gamma measurements combined with a shielding gammaray spectrometer. Based on a quasi-monochromatic gamma beam from the Shanghai Laser Electron Gamma Source (SLEGS), the feasibility of the measurement of production cross section for surveyed medical isotopes was simulated, and specific solutions for measuring medical radioisotopes with low production cross sections were provided. The feasibility of this method for high precision measurements of the reaction cross section of medical radioisotopes was demonstrated.
Subjects: Nuclear Science and Technology >> Nuclear Science and Technology submitted time 2024-03-12
Abstract: This paper presents a new technique for measuring the bunch length of a high-energy electron beam at a bunch-by-bunch rate in storage rings. This technique uses the time–frequency-domain joint analysis of the bunch signal to obtain bunch-by-bunch and turn-by-turn longitudinal parameters, such as bunch length and synchronous phase. The bunch signal is obtained using a button electrode with a bandwidth of several gigahertz. The data acquisition device was a high-speed digital oscilloscope with a sampling rate of more than 10 GS/s, and the single-shot sampling data buffer covered thousands of turns. The bunch length and synchronous phase information were extracted via offline calculations using Python scripts. The calibration coefficient of the system was determined using a commercial streak camera. Moreover, this technique was tested on two different storage rings and successfully captured various longitudinal transient processes during the harmonic cavity debugging process at the Shanghai Synchrotron Radiation Facility (SSRF), and longitudinal instabilities were observed during the single bunch accumulation process at Hefei Light Source (HLS). For Gaussian-distribution bunches, the uncertainty of the bunch phase obtained using this technique was better than 0.2 ps, and the bunch length uncertainty was better than 1 ps. The dynamic range exceeded 10 ms. This technology is a powerful and versatile beam diagnostic tool that can be conveniently deployed in high-energy electron storage rings.
Subjects: Physics >> Nuclear Physics submitted time 2024-03-10
Abstract: The utilization of a proton beam from the China Spallation Neutron Source (CSNS) for producing medical radioisotopes is appealing owing to its high current intensity and high energy. The medical isotope production based on the proton beam at the CSNS is significant for the development of future radiopharmaceuticals, particularly for the α-emitting radiopharmaceuticals. The production yield and activity of typical medical isotopes were estimated using the FLUKA simulation. The results indicate that the 300-MeV proton beam with a power of 100 kW at CSNS-II is highly suitable for proof-of-principle studies of most medical radioisotopes. In particular, this proton beam offers tremendous advantages for the large-scale production of alpha radioisotopes, such as 225Ac, whose theoretical production yield can reach approximately 57 Ci/week. Based on these results, we provide perspectives on the use of CSNS proton beams to produce radioisotopes for medical applications.