Effect of High Intensity Interval Training on Blood Glucose Control in Experimental Animal of Type 2 Diabetes Mellitus

分类： 医学、药学 >> 基础医学 提交时间： 2022-03-02

谭军

摘要：  Objective To explore the effect of high intensity interval training (HIIT) on blood glucose control in experimental animal of type 2 diabetes mellitus (T2DM) and to evaluate the quality of the included studies. Methods literatures were obtained by searching PubMed, EMbase, Web of Science, BIOSIS Preview and Cochrane Library. Chinese literatures were obtained through CNKI, WanFang Data, SinoMed and VIP Database; The collection and screening studies were conducted in strict accordance with inclusion/exclusion criteria. The methodological quality and reporting quality of the included studies were evaluated using SYRCLE's risk of bias tool for animal studies (SYRCLE) and Animal Research: Reporting In Vivo Experiments guidelines 2.0(ARRIVE2.0). Outcomes，such as body weight (BW), fasting blood glucose (FBG), fasting insulin (FINS), homeostasis model assessment of insulin resistance (HOMA) were meta-analyzed and evaluated by Grading of Recommendations Assessment, Development and Evaluation (GRADE). Results Twenty studies were included, including male mice (9) or rats (11). T2DM models have been developed mainly in two ways: high-fat diet and/or combined with streptozotocin (STZ) injection (15 articles), genetic modification (5 articles). Exercise and interval intensity are measured using VO2 max, maximum speed and slope, with 1-4.5 minutes of exercise and 15 second -3 minutes of interval, and the training duration was 8-13 weeks with 3-5 times of training a week. The SYRCLE’s result was mainly uncertain；None of the single items or the single studies assessed by ARRIVE 2.0 appeared complete. Standardized mean difference (SMD) combined the effect size of outcomes showed that compared with the sedentary control group, the heterogeneity was all large, and there are significant differences in FBG, HOMA. Very low quality of all evidence assessed by GRADE. Conclusions The effect of HIIT on blood glucose control is clear, but the influencing factors are complex, the risk of bias is high, the quality of reporting is low, the source of heterogeneity in outcomes is complex, and the quality of evidence is extremely low, which make its reliability and validity are questioned. It is recommended to use ARRIVE2.0 as a guide to increase the integrity and transparency of research information and improve research quality through experimental protocol registration and attachments.

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