Subjects: Medicine, Pharmacy >> Preclinical Medicine submitted time 2018-01-25 Cooperative journals: 《南方医科大学学报》
Abstract： Objective To investigate the relationship between atrial fibrillation (AF) and serum soluble CD163. Methods Atotal of 336 patients with heart valve disease were included in this study, including 167 with AF and 169 with sinus rhythm. The clinical data were compared between the two grops, and Logistic regression analysis was used to identify the risk factors associated with AF. Results The levels of total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), tumor necrosis factor (TNF), interleukin-6 (IL- 6), high-sensitivity C-reactive protein (hs-CRP) and left atrial diameter (LAD) all differed significantly between the two groups (P<0.05). Serum soluble CD163 levels in AF patients were significantly higher than those in patients with sinus rhythm (P<0.05). Serum soluble CD163 was positively correlated with TNF (r=0.244, P=0.244), IL-6 (r=0.186, P=0.186), hs-CRP(r=0.183, P=0.183) and LAD (r=0.194, P=0.194) in patients withAF. Logistic regression analysis showed that LAD, IL-6, TNF, hs-CRPand CD163 were all associated withAF. ROC curve analysis showed that the area under curve of serum soluble CD163 was 0.861 in patients withAF (CI 95%: 0.820-0.901, P<0.01) with a sensitivity and a specificity of 80.8 and 76.9%, respectively. Conclusion Serum soluble CD163 level may be a risk factor forAF,andanincreasedsolubleCD163levelmayindicateactiveinflammationinAFpatients.
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