Subjects: Medicine, Pharmacy >> Clinical Medicine submitted time 2022-07-20 Cooperative journals: 《中国全科医学》
Abstract： Background Obesity can lead to insulin resistance (IR) and lead to type 2 diabetes mellitus (T2DM), which seriously affects human health. Irisin is a newly discovered muscle and adipocytokine, which plays an important role in metabolic regulation. It is worth studying how its level changes in T2DM patients with obesity or overweight. Objective To investigate the level of serum Irisin in obesity or overweight patients with type 2 diabetes mellitus (T2DM), and to explore its correlation with body mass index (BMI), blood glucose, blood lipids, homeostasis insulin resistance index (HOMA-IR) and other factors.Methods A total of 119 T2DM patients hospitalized in the Department of Endocrinology, The First Affiliated Hospital of Anhui Medical University from December 2019 to June 2021 were selected. According to BMI, they were divided into diabetic overweight group (n=78) and diabetic normal weight group (n=41).Healthy subjects in our hospital during the same period were selected as the control group (n=52).Blood pressure, BMI, blood lipid, Glycosylated hemoglobin A1c（HbA1c）, fasting blood glucose (FBG), fasting insulin (FINS), HOMA-IR and Irisin levels were recorded.Results There were statistically significant differences in blood pressure, BMI, triglyceride (TG), high density lipoprotein cholesterol (HDL-C), HbA1c, FBG, FINS and HOMA-IR among three groups (P<0.05).The level of Irisin in normal weight diabetic group was lower than that in control group, and the level of Irisin in obesity or overweight diabetic group was lower than that in control group and normal weight diabetic group (P<0.05). Spearman correlation analysis showed that serum Irisin level was positively correlated with HDL-C, and negatively correlated with systolic blood pressure, diastolic blood pressure, BMI, TG, HbA1c, FBG, FINS, HOMA-IR.Multiple linear regression analysis showed that DBP, HbA1c, FBG and FINS were the influential factors of serum Irisin level (P<0.05).Conclusion The level of serum Irisin in T2DM patients with obesity or overweight is decreased, which is related to BMI, blood pressure, blood lipid and IR.
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