分类： 管理学 >> 管理学其他学科 提交时间： 2022-11-23 合作期刊: 《2022年第三届传播、创新和经济管理国际研讨会》
摘要： In the era of network media, the rapid development of online live broadcasting industry has magnified the advantages brought about by high value. Eyes, as an important part of the overall face score have also received extensive attention from live broadcast groups. Guided by the theoretical framework of visual communication, this paper analyzes the relationship between the eyes of webcast bloggers and user attraction from the perspective of phenomenology, and discusses its significance. It is found that hosts with peach blossom eyes often have stronger attraction. For the difference of webcast bloggers' eyes, users' strong intuitive feelings are often more important independent variables that affect users' choice. Users' love of the anchor will also be affected by multidimensional factors.
分类： 生物学 >> 生物物理学 >> 衰老生物学 提交时间： 2016-05-05
摘要： microRNA-9 (miR-9) is highly expressed in the nervous system across species and plays essential roles in neurogenesis and axon growth; however, little is known about the mechanisms that link miR-9 with dendrite growth. Using an in vivo model of Drosophila class I dendrite arborization (da) neurons, we show that miR-9a, a Drosophila homolog of mammalian miR-9, downregulates the cadherin protein Flamingo (Fmi) thereby attenuating dendrite development in a non-cell autonomous manner. In miR-9a knockout mutants, the dendrite length of a sensory neuron ddaE was significantly increased. Intriguingly, miR-9a is specifically expressed in epithelial cells but not in neurons, thus the expression of epithelial but not neuronal Fmi is greatly elevated in miR-9a mutants. In contrast, overexpression of Fmi in the neuron resulted in a reduction in dendrite growth, suggesting that neuronal Fmi plays a suppressive role in dendrite growth, and that increased epithelial Fmi might promote dendrite growth by competitively binding to neuronal Fmi. Fmi has been proposed as a G protein-coupled receptor (GPCR), we find that neuronal G protein Gq (Gq), but not Go, may function downstream of Fmi to negatively regulate dendrite growth. Taken together, our results reveal a novel function of miR-9a in dendrite morphogenesis. Moreover, we suggest that Gq might mediate the intercellular signal of Fmi in neurons to suppress dendrite growth. Our findings provide novel insights into the complex regulatory mechanisms of microRNAs in dendrite development, and further reveal the interplay between the different components of Fmi, functioning in cadherin adhesion and GPCR signalling. (c) 2015 Wiley Periodicals, Inc. Develop Neurobiol 76: 225-237, 2016
分类： 物理学 >> 交叉学科物理及相关领域的科学与技术 提交时间： 2016-05-04
摘要： Molecular dynamics simulations for aqueous sodium chloride solutions were carried out at various concentrations. Supplementary to the Debye-Huckel theory, reversible transient nucleation of ions was observed even in dilute solutions. The average size of formed ion clusters and the lifetime of ion pairs increases with concentration until the saturation point, when ion clusters become stable and individual ions adjust their positions to form ordered lattice structures, leading to irreversible ion crystallization, which is beyond the description of the classical nucleation theory.
分类： 医学、药学 >> 基础医学 提交时间： 2017-12-27 合作期刊: 《南方医科大学学报》
摘要： Objective Both of gp91 phox (an isoform of nicotinamide adenine dinucleotide phosphate-reduced oxidases) and Src (a non-receptor protein tyrosine kinase) play a prominent role in mediating hypoxia/reoxygenation injury of neurons. The present study was designed to investigate the neuroprotective effect of equol, a predominant active metabolite of daidzein, against hypoxia/reoxygenation injury in rat pheochromocytoma cell line (PC12) and explore the underlying mechanisms. Methods PC12 cells exposed to hypoxia/reoxygenation injury were examined for reactive oxygen species (ROS) using dihydroethidium and 2', 7'-dichlorofluorescein diacetate and analyzed for changes in lactate dehydrogenase (LDH) activity and malondialdehyde (MDA)content. The expression levels of gp91 phox and phosphorylated Src-Tyr416 (p-Src) were measured using Western blotting. Results Equol dose-dependently restored the cell viability and decreased LDH activity and MDA content in culture medium of PC12 cells exposed to hypoxia/reoxygenation. Pretreatment of the cells with 10 -5 and 10 -6 mol/L equol inhibited hypoxia/reoxygenation-induced increase of ROS. PC12 cells treated with equol prior to hypoxia/reoxygenation injury showed significant enhancement of the protein levels of gp91 phox and p-Src. Conclusion Equol confers neuroprotection against hypoxia/reoxygenation injury in PC12 cells by inhibiting the generation of ROS very likely as a result of down-regulation of gp91 phox and inhibition of Src phosphorylation.
分类： 地球科学 >> 地质学 提交时间： 2017-08-24 合作期刊: 《古脊椎动物学报》
摘要： The present paper revalidated Asiatosuchus nanlingensis Young, 1964 and Eoalligator chunyii Young, 1964 in taxonomy based on a detailed comparative study on those relevant specimens. New information derived from this study revealed that A. nanlingensis and E. chunyii were truly distinguishable from each other and therefore, diagnosis was further revised for each of them. A. nanlingensis is large, with a moderately long or a very elongate snout, and characterised mainly by the combination of the following characters such as: the quadrate with a lateral condyle much larger than the medial one, the surangular pinched off before reaching the end of the retroarticular process, the dental margins (at least the posterior portion) of the jaws nearly straight, and the presence of a fossa/sulcus on the lateral surface of the surangular lateral to the mandibular fossa. E. chunyii is a median-sized, short-snouted animal and characterised mainly by the combination of the following characters such as: the condyles of the quadrate similar in size, the dental margins of the jaws strongly concavo-convex, the dentary symphyses very short, the splenial not entering the mandibular symphysis, and the presence of a fossa/sulcus on the lateral surface of the surangular lateral to the mandibular fossa. With new information derived from this study, the phylogenetic relationships of A. nanlingensis and E. chunyii were tested, which did not support the view that the two species formed a monophyletic clade and opposed that E. chunyii could be considered as the synonym of A. nanlingensis. 根据对有关标本的详细对比研究，重新评估了南岭亚洲鳄(Asiatosuchus nanlingensis Young, 1964)和存义始猛鳄(Eoalligator chunyii Young, 1964)的分类。获得的新信息表明这两种是可以彼此区分的，因此对它们各自的鉴定特征进行了进一步修订。南岭亚洲鳄是个大型种类，它很可能具有中等或很长的吻部(眶前段), 主要由以下一些特征组合界定：方骨外髁比内髁大很多，上隅骨在反关节突近端尖灭，上、下颌齿缘(至少后段)几近平直，以及在下颌关节窝外侧上隅骨表面具一凹或纵沟。存义始猛鳄是个中型种类，主要可以由下列特征组合界定：方骨内、外关节髁大小几近相当，上、下颌齿缘强烈凹凸不平，齿骨联合很短，夹板骨不进入下颌联合，以及在下颌关节窝外侧上隅骨表面具一凹或纵沟。根据新的信息对南岭亚洲鳄和存义始猛鳄原来的系统关系进行了检验，所得结果不支持南岭亚洲鳄和存义始猛鳄可以形成一单系分支及反对后者是前者的同物异名。虽然本文研究表明南岭亚洲鳄可以和其他种类区分，但是在系统关系上却不能和亚洲鳄典型种(葛氏亚洲鳄Asiatosuchus grangeri)归于同一支系，如此应该为其建立一属。然而，鉴于南岭亚洲鳄标本太不完整，在没有新的、更完整的标本发现之前，本文仍沿用其原名，如德国亚洲鳄(Asiatosuchus germanicus)一样，后者也不和亚洲鳄典型种归于同一支系。
分类： 环境科学技术及资源科学技术 >> 环境科学技术基础学科 提交时间： 2022-03-15 合作期刊: 《干旱区科学》
摘要： The status of regional biodiversity is determined by habitat quality. The effective assessment of habitat quality can help balance the relationship between economic development and biodiversity conservation. Therefore, this study used the InVEST model to conduct a dynamic evaluation of the spatial and temporal changes in habitat quality of the Tarim River Basin in southern Xinjiang Uygur Autonomous Region of China by calculating the degradation degree levels for habitat types that were caused by threat factors from 1990 to 2018 (represented by four periods of 1990, 2000, 2010 and 2018). Specifically, we used spatial autocorrelation analysis and Getis-Ord G* i analysis to divide the study area into three heterogeneous units in terms of habitat quality: cold spot areas, hot spot areas and random areas. Hemeroby index, population density, gross domestic product (GDP), altitude and distance from water source (DWS) were then chosen as the main disturbance factors. Linear correlation and spatial regression models were subsequently used to analyze the influences of disturbance factors on habitat quality. The results demonstrated that the overall level of habitat quality in the TRB was poor, showing a continuous degradation state. The intensity of the negative correlation between habitat quality and Hemeroby index was proven to be strongest in cold spot areas, hot spot areas and random areas. The spatial lag model (SLM) was better suited to spatial regression analysis due to the spatial dependence of habitat quality and disturbance factors in heterogeneous units. By analyzing the model, Hemeroby index was found to have the greatest impact on habitat quality in the studied four periods (1990, 2000, 2010 and 2018). The research results have potential guiding significance for the formulation of reasonable management policies in the TRB as well as other river basins in arid areas.
分类： 核科学技术 >> 裂变堆工程技术 提交时间： 2023-06-18 合作期刊: 《Nuclear Science and Techniques》
摘要： Oxygen control technology is a critical issue for compatibility of candidate structural materials with liquid lead-bismuth eutectic (LBE) in accelerator driven systems. Performances of a self-developed Pt/air sensor and another one from Karlsruher Institute of Technology (KIT) were tested in stagnant oxygen-saturated liquid LBE. Calibrations showed that the trend and values of corrected electromotive force (EMF) of the self-developed sensor, with a bias voltage of 20 mV, were consistent with theoretical results above 425 ℃, and similar results were obtained in cross-calibration test with EMF value of KIT sensor as reference. In stability test at 450 ℃ for 100 hours, the KIT sensor performed better than the self-developed one, which showed signal fluctuations. Both sensors exhibited quick response to temperature variations in the responsiveness test.
分类： 核科学技术 >> 核探测技术与核电子学 提交时间： 2023-06-18 合作期刊: 《Nuclear Science and Techniques》
摘要： Field Programmable Gate Array (FPGA), combined with ARM (Advanced RISC Machines) is increasingly employed in the portable data acquisition (DAQ) system for nuclear experiments to reduce the system volume and achieve powerful and multifunctional capacity. High-speed data transmission between FPGA and ARM is one of the most challenging issues for system implementation. In this paper, we propose a method to realize the high-speed data transmission by using the FPGA to acquire massive data from FEE (Front-end electronics) and send it to the ARM whilst the ARM to transmit the data to the remote computer through the TCP/IP protocol for later process. This paper mainly introduces the interface design of the high-speed transmission method between the FPGA and the ARM, the transmission logic of the FPGA, and the program design of the ARM. The theoretical research shows that the maximal transmission speed between the FPGA and the ARM through this way can reach 50 MB/s. In a realistic nuclear physics experiment, this portable DAQ system achieved 2.2 MB/s data acquisition speed.
分类： 核科学技术 >> 裂变堆工程技术 提交时间： 2023-06-18 合作期刊: 《Nuclear Science and Techniques》
摘要： After the Fukushima Dai-ichi nuclear power plant accident on March 11, 2011, the radioactivity released from the accident was transported around the globe by atmospheric processes. The radioactivity monitoring program on atmospheric particulate in Lanzhou, China was activated by GSCDC to detect the input radionuclides through atmospheric transport. Several artificial radionuclides were detected and measured in aerosol samples from March 26 to May 2, 2011. The peaked activity concentrations (in mBq/m3) were: 1.194 (131I), 0.231 (137Cs), 0.173 (134Cs) and 0.008 (136Cs), detected on April 6, 2011. The average activity ratio of 131I/137Cs and 134Cs/137Cs in air were 13.5 and 0.78. The significant increase of 137Cs activity concentration, one order of magnitude higher than pre-Fukushima accident levels, in ground level aerosol was observed in 2013, as its resuspension from soil. The back-trajectory analysis simulated by NOAA-ARL HYSPLIT shows a direct transfer of the air masses released from Fukushima to Lanzhou across the Pacific Ocean, North America and Europe at the height close to 9000 m AGL. The value of effective dose for inhalation is close to one millionth of the annual limit for the general public.
分类： 地球科学 >> 地质学 提交时间： 2017-08-24 合作期刊: 《古脊椎动物学报》
摘要： Tetrapod assemblages provide a useful means for global correlation of the terrestrial Triassic sedimentary deposits, but currently no reliable temporal framework has been achieved for the Middle Triassic tetrapod assemblages. Here we report U-Pb zircon chemical abrasion–thermal ionization mass spectrometry dates for five volcanic ashes interbedded with vertebrate fossils from the Ermaying and Tongchuan formations of China. Our results support a late Anisian age for the Sinokannemeyeria Fauna and an early Ladinian age for Yonghesuchus Fauna. It is now possible, through biostratigraphic correlation, to provide accurate ages to other Middle Triassic successions such as the Upper Cynognathus Assemblage Zone of the Karoo of South Africa, the Eryosuchus fauna of the Donguz Suite of Russia and the Karamayi Formation of Xinjiang, China. The base of Anisian (Lower/Middle Triassic boundary) should lie below the base of the Ermaying Formation in the Ordos Basin. 四足动物组合带是全球陆相三叠系对比的有力手段，但是迄今为止中三叠世的四足动物组合尚没有可靠的时间框架。本文报道了五个采自二马营组和铜川组，与四足动物化石共同产出的火山凝灰岩样品的锆石化学剥蚀-热电离质谱法年龄。结果表明中国肯氏兽动物群时代为安尼期晚期，而永和鳄的时代为拉丁期早期。通过生物地层对比，这一结果还为其他中三叠世的四足动物组合，如南非的犬颌兽带上部、俄罗斯的引鳄动物群以及新疆的克拉玛依组提供了准确的年龄。鄂尔多斯盆地下中三叠统界线应低于二马营组底界。
分类： 核科学技术 >> 核探测技术与核电子学 提交时间： 2023-06-18 合作期刊: 《Nuclear Science and Techniques》
ZONG Yang
ZHANG Zi-Min
YUAN Ping
SHEN Xiao-Kang
ZHAO Quan-Tang
WANG Yan-Ru
LI Zhong-Ping
CAO Shu-Chun
LIU Ming
JING Yi
摘要： Dielectric wall accelerator (DWA), towards high gradient acceleration field (30 MeV/m100 MeV/m), is under development at Institute of Modern Physics. A prototype was designed and constructed to prove the principle. This needs a short pulse high current electron source to match the acceleration field generated by the Blumlein-type pulse forming lines (PFLs). In this paper, we report the design and test of a new type short pulse high current electron gun based on principle of vacuum arc discharge. Electron beams of 100 mA with pulse width of 10 ns were obtained.
分类： 核科学技术 >> 粒子加速器 提交时间： 2023-06-18 合作期刊: 《Nuclear Science and Techniques》
TANG Zheng-Bo
MA Zhen-Yu
HOU Hong-Tao
MAO Dong-Qing
FENG Zi-Qiang
WANG Yan
XU Kai
LUO Chen
LI Zheng
SHI Jing
LIU Jian-Fei
摘要： The 500 MHz 5-cell superconducting RF (SRF) cavity was designed aiming to be a candidate cavity for high current accelerators. A copper prototype cavity and a niobium cavity were fabricated at SINAP in 2012. In order to ensure these cavities get the desired frequency and a good field flatness higher than 98%, frequency control was implemented in the manufacturing process and pre-tuning has been done using a simple pre-tuning frame based on the bead-pull pre-tuning method. Then, TM010- mode frequency within 5 kHz from the target frequency was achieved and the field flatness reached 98.9% on the copper prototype cavity. Finally, the same procedure was applied to the niobium cavity to obtain a field flatness better than 98% which benefited the cavity performance in the vertical testing.
分类： 地球科学 >> 地质学 提交时间： 2017-10-09 合作期刊: 《古脊椎动物学报》
WANG Yan-Fang
WEI Cun-Feng
QUE Jie-Min
ZHANG Wen-Ding
SUN Cui-Li
SHU Yan-Feng
HOU Ye-Mao
ZHANG Jiu-Chang
SHI Rong-Jian
WEI Long
摘要： The traditional serial grinding method used to investigate the internal structure of fossils cannot be readily applied to valuable fossil specimens due to its destructive and time-consuming nature. Computed tomography (CT) is an ideal non-destructive technique for investigating the internal structure of fossils, in which thousands of serial images are obtained and used to produce an accurate reconstruction of the internal morphology. This paper reviews the design, development and applications of the first CT system in China dedicated exclusively to scanning fossils. The 225 kV three-dimensional (3D) fossil micro-CT (225-3D-μCT) is capable of high-resolution volumetric imaging, with a resolution up to 5 μm, and can accommodate specimens measuring up to 100 mm in diameter and 100 mm in length. The 450 kV ordinary fossil CT (450-TY-ICT) can produce high signal-to-noise ratio (SNR) images of specimens ranging up to 800 mm in diameter and 1000 mm in length, with a resolution up to 200 μm. Two paleontological CT facilities represent a high-performance platform offering the functional diversity needed to meet the demands of studying fossils at a variety of different scales. The two machines have become indispensable for paleontological research in China.
分类： 核科学技术 >> 粒子加速器 提交时间： 2023-06-18 合作期刊: 《Nuclear Science and Techniques》
ZHANG Zhi-Gang
ZHAO Yu-Bin
XU Kai
ZHENG Xiang
LI Zheng
ZHAO Shen-Jie
CHANG Qiang
HOU Hong-Tao
MA Zhen-Yu
LUO Chen
MAO Dong-Qing
SHI Jing
WANG Yan
LIU Jian-Fei
摘要： The low level radio frequency (LLRF) system for booster accelerator at Shanghai Synchrotron Radiation Facility (SSRF) was upgraded by a digital controller based on field programmable gate array (FPGA) technology. Parameters of voltage, frequency and field flatness in the two 5-cell cavities are controlled to meet the requirements of booster. In this article, the ramping curve of cavity voltage, amplitude and phase control loop with vector sum of the two 5-cell cavities, tuning loop and field flatness loop are analyzed and discussed in detail. A different method in tuning loop is adopted due to the limitations of ADC channels. The function realizes energy ramping of electron beam from 150 MeV to 3.5 GeV with a repetition rate of 2 Hz. With the new LLRF controller, the phase stability at ramping mode in 10 hours long operation is improved from � 1.5� (RMS) with open loop to � 0.15� (RMS) with close loop, while the detuning phase and field flatness are maintained to within � 2癮nd � 1%, respectively.
分类： 核科学技术 >> 粒子加速器 提交时间： 2023-06-18 合作期刊: 《Nuclear Science and Techniques》
MA Zhen-Yu
LIU Jian-Fei
HOU Hong-Tao
WANG Yan
SHI Jing
LUO Chen
FENG Zi-Qiang
MAO Dong-Qing
TANG Zheng-Bo
LI Zheng
ZHAO Shen-Jie
ZHANG Zi-Gang
ZHENG Xiang
ZHAO Yu-Bin
摘要： Surface preparation is an important processing in production procedures of superconducting niobium cavities, deciding whether the performance of the niobium cavities can meet the specifications. A series of surface preparation methods and relevant apparatuses have been constructed at Shanghai Institute of Applied Physics (SINAP) and the standard procedures of cavity processing were established and successfully applied to different types of cavities. With standard surface preparation procedures on the 500 MHz 5-cell niobium cavity, the cavity accelerating voltage at T=4.2 K reached 7.5 MV while its quality factor was still higher than 1�109. The accelerating gradient of the IMP-HWR010 cavity reached 4.9 MV/m with the quality factor of better than 3�108 at 4.2 K.
分类： 生物学 >> 生态学 提交时间： 2017-11-17
Li, L (Li, Li)
Zhang, QJ (Zhang, Quanjun)
Yang, HQ (Yang, Huaqiang)
Zou, QJ (Zou, Qingjian)
Lai, CD (Lai, Chengdan)
Jiang, F (Jiang, Fei)
Zhao, P (Zhao, Ping)
Luo, ZW (Luo, Zhiwei)
Yang, JY (Yang, Jiayin)
Chen, Q (Chen, Qian)
Wang, Y (Wang, Yan)
Newsome, PN (Newsome, Philip N.)
Frampton, J (Frampton, Jon)
Maxwell, PH (Maxwell, Patrick H.)
Li, WJ (Li, Wenjuan)
Chen, SH (Chen, Shuhan)
Wang, DY (Wang, Dongye)
Siu, TS (Siu, Tak-Shing)
Tam, S (Tam, Sidney)
Tse, HF (Tse, Hung-Fat)
摘要： From the (a)CAS Key Laboratory of Regenerative Biology, Joint School of Life Sciences, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou 510530, China, and Guangzhou Medical University, Guangzhou 511436, China, (b)CAS Key Laboratory of Regenerative Biology and Guangdong Provincial Key Laboratory of Stem Cells and Regenerative Medicine, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou 510530, China, (c)Laboratory of RNA, Chromatin, and Human Disease, CAS Key Laboratory of Regenerative Biology and Guangdong Provincial Key Laboratory of Stem Cells and Regenerative Medicine, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou 510530, China, (d)Cardiology Division, Department of Medicine, Queen Mary Hospital, The University of Hong Kong, Hong Kong SAR, China, (e)Hong Kong-Guangdong Stem Cell and Regenerative Medicine Research Centre, The University of Hong Kong and Guangzhou Institutes of Biomedicine and Health, Hong Kong SAR, China, (f)Department of Ophthalmology, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou 510630, China, (g)State Key Laboratory of Organ Failure Research, Guangdong Provincial Key Laboratory of Viral Hepatitis Research, Guangdong Provincial Research Center for Liver Fibrosis, Department of Infectious Diseases and Hepatology Unit, Nanfang Hospital and (h)Biomedical Research Center, Southern Medical University, Guangzhou 510515, China, (i)Institute of Immunology and Immunotherapy, College of Medical and Dental Sciences, (j)National Institute for Health Research (NIHR) Birmingham Liver Biomedical Research Unit and Centre for Liver Research, and (k)Institute of Cancer and Genomic Sciences, College of Medical and Dental Sciences, University of Birmingham, Birmingham B15 2TT, United Kingdom, (l)Cambridge Institute for Medical Research, Wellcome Trust/Medical Research Council (MRC) Building, Cambridge CB2 0XY, United Kingdom, mDepartment of Clinical Biochemistry Unit, Queen Mary Hospital, Hong Kong SAR, China, (n)Department of Medicine, University of Hong Kong-Shenzhen Hospital, Shenzhen 518053, Guangdong, China, and (o)Laboratory of Metabolism and Cell Fate, CAS Key Laboratory of Regenerative Biology and Guangdong Provincial Key Laboratory of Stem Cells and Regenerative Medicine, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou 510530, Guangdong, China
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