分类： 医学、药学 >> 临床医学 提交时间： 2023-10-09 合作期刊: 《中国全科医学》
摘要： The relationship between fatigue and diseases continues to receive widespread attention and fatigue is becoming an important public health issue. The World Health Organization added overexertion to the International Classification of Diseases in May, 2019, which had took effect globally in 2022. The concept of chronic fatigue syndrome （CFS） was proposed earlier, while its etiology and pathogenesis still remain unclear till now, resulting in lacking of specific therapies, which may be due to the involvement of multiple systems and the difficulties in distinguishing CFS symptoms from anxiety/depression, the complexity of the diagnosis and treatment of thedisease and researches on it are also increased. This review initially investigates the characteristics of CFS associated with anxiety/depression, further explores the similarities and differences in indicator change characteristics between CFS and anxiety/depression in terms of the current research status on biological indicators, imaging abnormalities and treatment, in order to provide new ideas for the diagnosis and typing of CFS, and provide suggestions for conducting clinical and basic researches on the disease.
分类： 动力与电气工程 >> 工程热物理学 提交时间： 2017-06-26 合作期刊: 《热科学学报》
摘要： The advantage of high efficiency, low SFC (Specific Fuel Consumption), ultra-high bypass ratio turbofan engine attracts more and more attention in modern commercial engine. The intermediate turbine duct (ITD), which connects high pressure turbine (HPT) with low pressure turbine (LPT), has a critical impact on the overall performance of turbine by guiding flow coming from HPT to LPT without too much loss. Therefore, it becomes more and more urgent to master the technique of designing aggressive, even super-aggressive ITD. Much more concerns have been concentrated on the duct. However, in order to further improve turbine, LPT nozzle is arranged into ITD to shorten low pressure axle. With such design concept, it is obvious that LPT nozzle flow field is easily influenced by upstream duct structure, but receives much less interests on the contrary. In this paper, numerical method is used to investigate the effects of length of ITD with upstream swirl blades on LPT nozzle. Nine models with the same swirl and nozzle blades, while the length of ITD is the only parameter to be changed, will be discussed. Finally, several conclusions and advices for designers are summarized. After changing axial length of ducts, inlet and outlet flow field of nozzle differs, correspondingly. On the other hand, the shearing stress on nozzle blade (suction and pressure) surface presents individual feature under various inlet flow. In addition to that, "Clocking-like effect" is described in this paper, which will contribute much to the pressure loss and should be paid enough attention.
分类： 物理学 >> 普通物理:统计和量子力学,量子信息等 提交时间： 2017-05-02
摘要： A superhydrophobic zeolitic imidazolate framework (ZIF-90) with high steam stability is prepared through post-functionalization via an amine condensation reaction. The developed superhydrophobic ZIF-90 is highly promising as an effective and reusable adsorbent for bio-alcohol recovery.
分类： 光学 >> 量子光学 提交时间： 2023-02-19
摘要： Photon carries linear momentum and angular momentum simultaneously. Within the light-matter interaction process, exchange of linear momentum results in optical forces, whereas exchange of angular momentum leads to optical torques. Use of optical forces (light pressure or damping) have been long and wide in quantum optomechanics, however, those of optical torque and optical angular momentum are not. Here we propose a theoretical framework based on optical angular momentum and optical torques to derive the Hamiltonians of cavity orbital and spin angular momentum optomechanical systems, respectively. Moreover, based on the method, we successfully obtain the Hamiltonian of the complex angular momentum optomechanical systems consisting of micro-cavity and several torsional oscillators, whose reflection coefficients are non-unit. Our results indicate the general applicability of our theoretical framework for the Hamiltonian of angular momentum optomechanical systems and extend the research scope of quantum optomechanics.
分类： 地球科学 >> 地理学 提交时间： 2017-12-18 合作期刊: 《干旱区科学》
摘要： Most remote sensing studies assess the desertification using vegetation monitoring method. But it has the insufficient precision of vegetation monitoring for the limited vegetation cover of the desertification region. Therefore, it offers an alternative approach for the desertification research to assess sand dune and sandy land change using remote sensing in the desertification region. In this study, the indices derived from the well-known tasseled cap transformation (TCT), tasseled cap angle (TCA), disturbance index (DI), process indicator (PI), and topsoil grain size index (TGSI) were integrated to monitor and assess the desertification at the thirteen study sites including sand dunes and sandy lands distributed in the the Mongolian Plateau (MP) from 2000 to 2015. A decision tree was used to classify the desertification on a regional scale. The average overall accuracy of 2000, 2005, 2010 and 2015 desertification classification was higher than 90%. Results from this study indicated that integration of the advantages of TCA, DI and TGSI could better assess the desertification. During the last 16 years, Badain Jaran Desert, Tengger Desert, and Ulan Buh Desert showed a relative stabilization. Otindag Sandy Land and the deserts of Khar Nuur, Ereen Nuur, Tsagan Nuur, Khongoryn Els, Hobq, and Mu Us showed a slow increasing of desertification, whereas Bayan Gobi, Horqin and Hulun Buir sandy lands showed a slow decreasing of desertification. Compared with the other 11 sites, the fine sand dunes occupied the majority of the Tengger Desert, and the coarse sandy land occupied the majority of the Horqin Sandy Land. Our findings on a three or four years’ periodical fluctuated changes in the desertification may possibly reflect changing precipitation and soil moisture in the MP. Further work to link the TCA, DI, TGSI, and PI values with the desertification characteristics is recommended to set the thresholds and improve the assessment accuracy with field investigation.
分类： 天文学 >> 天文学 提交时间： 2023-02-19
摘要： We investigate the formation and eruption of hot channels associated with the M6.5 class flare (SOL2015-06-22T18:23) occurring in NOAA AR 12371 on 2015 June 22. Two flare precursors are observed before the flare main phase. Observations in 94 {\AA} and 131 {\AA} by SDO/AIA have revealed the early morphology of the first hot channel as a group of hot loops, which is termed as seed hot channel. A few seed hot channels are formed above the polarity inversion line (PIL) and the formation is associated with footpoint brightenings' parallel motion along the PIL, which proceeds into the early stage of the flare main phase. During this process, seed hot channels build up and rise slowly, being accelerated at the peak of the second precursor. They merge in the process of acceleration forming a larger hot channel, which then forms an "inverted {\gamma}" shape kinking structure. Before the flare peak, the second kinking hot channel with negative crossing appears near the first kinking hot channel that has erupted. The eruption of these two hot channels produce two peaks on the main flare's GOES light curve. The footpoint brightenings' propagation along the PIL indicate that the first kinking hot channel may be formed due to zipper reconnection. The occurrence of merging between seed hot channels observed by AIA is supported by the extrapolated nonlinear force-free field models. The observed writhing motion of the first kinking hot channel may be driven by the Lorentz force.
分类： 天文学 >> 天文学 提交时间： 2023-02-19
摘要： We investigate the formation and eruption of hot channels associated with the M6.5 class flare (SOL2015-06-22T18:23) occurring in NOAA AR 12371 on 2015 June 22. Two flare precursors are observed before the flare main phase. Observations in 94 {\AA} and 131 {\AA} by SDO/AIA have revealed the early morphology of the first hot channel as a group of hot loops, which is termed as seed hot channel. A few seed hot channels are formed above the polarity inversion line (PIL) and the formation is associated with footpoint brightenings' parallel motion along the PIL, which proceeds into the early stage of the flare main phase. During this process, seed hot channels build up and rise slowly, being accelerated at the peak of the second precursor. They merge in the process of acceleration forming a larger hot channel, which then forms an "inverted {\gamma}" shape kinking structure. Before the flare peak, the second kinking hot channel with negative crossing appears near the first kinking hot channel that has erupted. The eruption of these two hot channels produce two peaks on the main flare's GOES light curve. The footpoint brightenings' propagation along the PIL indicate that the first kinking hot channel may be formed due to zipper reconnection. The occurrence of merging between seed hot channels observed by AIA is supported by the extrapolated nonlinear force-free field models. The observed writhing motion of the first kinking hot channel may be driven by the Lorentz force.
分类： 天文学 >> 天文学 提交时间： 2023-02-19
摘要： Although the spatial curvature has been precisely determined via the cosmic microwave background (CMB) observation by Planck satellite, it still suffers from the well-known cosmic curvature tension. As a standard siren, gravitational waves (GWs) from binary neutron star mergers provide a direct way to measure the luminosity distance. In addition, the accelerating expansion of the universe may cause an additional phase shift in the gravitational waveform, which allows us to measure the acceleration parameter. This measurement provides an important opportunity to determine the curvature parameter $\Omega_k$ in the GW domain based on the combination of two different observables for the same objects at high redshifts. In this study, we investigate how such an idea could be implemented with future generation of space-based DECi-hertz Interferometer Gravitational-wave Observatory (DECIGO) in the framework of two model-independent methods. Our results show that DECIGO could provide a reliable and stringent constraint on the cosmic curvature at a precision of $\Delta\Omega_k$=0.12, which is comparable to existing results based on different electromagnetic data. Our constraints are more stringent than the traditional electromagnetic method from the Pantheon SNe Ia sample, which shows no evidence for the deviation from the flat universe at $z\sim 2.3$. More importantly, with our model-independent method, such a second-generation space-based GW detector would also be able to explore the possible evolution $\Omega_k$ with redshifts, through direct measurements of cosmic curvature at different redshifts ($z\sim 5$). Such a model-independent $\Omega_k$ reconstruction to the distance past can become a milestone in gravitational-wave cosmology.
分类： 天文学 >> 天文学 提交时间： 2024-03-29 合作期刊: 《Research in Astronomy and Astrophysics》
摘要： Twenty-five typical massive white dwarfs (WDs) are selected and the proton decay reaction catalyzed by magnetic monopoles (MMs) for these WDs is discussed. A velocity-dependent correction factor strongly affects the cross-section. We find that a strong suppression controls the monopole catalysis of nucleon decay by the correction factor. The maximum number of MMs is captured and the luminosity can be 2.235 × 1021 and 1.7859 × 1032erg s−1 (e.g., for the O+Ne core mass WD J055631.17+130639.78). The luminosities of most massive WDs agree well with the observations at relatively low temperatures (e.g., T6 = 0.1), but can be three and two orders of magnitude higher than those of the observations for model (I) and (II) at relatively high temperatures (e.g., T6 = 10), respectively. The luminosities of model (I) are about one order of magnitude higher than those of model (II). Since we consider the effect of the number of MMs captured on the mass–radius relation and the suppression of the proton decay by the correction factor, the study by model (II) may be an improved estimation.
分类： 药物科学 >> 生物化学 提交时间： 2024-06-14
Huixu Feng
Guobin Liu
Luhan Li
Xuelian Ren
Yue Jiang
Wanting Hou
Ruilong Liu
Kun Liu
Hong Liu
He Huang
摘要： Hyperlipidemia (HLP) is a prevalent systemic metabolic disorder characterized by disrupted lipid metabolism. Statin drugs have long been the primary choice for managing lipid levels, but intolerance issues have prompted the search for alternative treatments. Matrine, a compound derived from the traditional Chinese medicine Kushen, exhibits anti-inflammatory and lipid-lowering properties. Nevertheless, the mechanism by which matrine modulates lipid metabolism remains poorly understood. Here, we investigated the molecular mechanisms underlying matrine’s regulation of lipid metabolism. Employing quantitative proteomics, we discovered that matrine increases the expression of LDL receptor (LDLR) in HepG2 and A549 cells, with subsequent experiments validating its role in enhancing LDL uptake. Notably, in hyperlipidemic hamsters, matrine effectively lowered lipid levels without affecting body weight, which highlights LDLR as a critical target for matrine’s impact on hyperlipidemia. Moreover, matrine’s potential inhibitory effects on tumor cell LDL uptake hint at broader applications in cancer research. Additionally, Thermal Proteome Profiling (TPP) analysis identified lipid metabolism-related proteins that may interact with matrine. Together, our study reveals matrine’s capacity to upregulate LDLR expression and highlights its potential in treating hyperlipidemia. These findings offer insights into matrine’s mechanism of action and open new avenues for drug research and lipid metabolism regulation.
分类： 药物科学 >> 生物化学 提交时间： 2024-06-14
Yue Jiang
Xuelian Ren
Jing Zhao
Guobin Liu
Fangfang Liu
Xinlong Guo
Ming Hao
Hong Liu
Kun Liu
He Huang
摘要： Gemcitabine (GEM) is a potent chemotherapeutic agent widely employed in the treatment of various cancers, notably pancreatic cancer. Despite its clinical success, challenges related to GEM resistance and toxicity persist. Therefore, there is a pressing need for a deeper understanding of its intracellular mechanisms and potential targets. In this study, we utilized quantitative proteomics and thermal proteome profiling (TPP) to elucidate the effects of GEM. Our proteomic analysis revealed that GEM primarily affected DNA synthesis, leading to the upregulation of cell cycle and DNA replication proteins. Additionally, enrichment analysis highlighted the activation of the p53 pathway, shedding light on GEM-induced apoptosis mechanisms. Notably, we observed the upregulation S-phase kinase-associated protein 2 (SKP2), a cell cycle and chemoresistance regulator, in response to GEM treatment. Combining SKP2 inhibition with GEM showed synergistic effects in both cellular and animal models, suggesting SKP2 as a potential target for enhancing GEM sensitivity and overcoming chemoresistance. Furthermore, through TPP, we explored potential binding targets of GEM, which implies GEM’s broad anticancer effects. Together, these findings provide valuable insights into GEM’s molecular mechanisms and offer potential targets for improving treatment efficacy. This research holds the promise of advancing personalized treatment strategies and opening avenues for novel combination therapies to enhance outcomes in pancreatic cancer.
分类： 医学、药学 >> 临床医学 提交时间： 2020-02-28
Luo, Sihui
Liu, Wei
Liu, Zhenjun
Zheng, Xueying
Ling, Ping
Ding, Yu
Hong, Changxing
Liu, Zhirong
Liu, Jian
Weng, Jianping
摘要： Here we reported a case of asymptomatic carrier of SARS-CoV-2 infection. A 50-year old woman, lived with her husband in Anqing(Anhui, China) with no significant past medical history, travel history to Wuhan or adjacent area, or exposure to wild animals. She took throat swab test for SARS-CoV-2 nucleic acid due to her husband’s close contact with patients who had SARS-CoV-2 infection. Her results were confirmed positive on February 6, 2020. But she did not report elevation of temperature measurement, nor respiratory or gastrointestinal symptoms and her chest CT scan showed no significant abnormalities. She was hospitalized on February 6 and treated with antiviral agents. During her hospitalization, apart from a mild elevation of liver enzymes after 10-day treatment of lopinavir/ritonavir, she was asymptomatic, with her blood cell count, live and renal function largely normal. Her subcutaneous oxygen saturation stayed above 97%. Chest CT scan was repeated on February 11 and 20, and both were negative for signs of viral pneumonia. Notably, a second set of throat swabs and anal swabs were sent to test for SARS-CoV-2 on February 19, and the results were still confirmed positive. This is a confirmed case of asymptomatic carrier of SARS-CoV-2 infection. Her persistent positive findings in both throat and anal swabs suggested the possibility of healthy carrier of the virus, which adds to the difficulty in preventing transmission of the disease.
分类： 物理学 >> 普通物理:统计和量子力学,量子信息等 提交时间： 2017-05-02
摘要： Titania-hydroxyapatite (HA) nanocomposites were fabricated by wet chemical synthesis approach. HA exhibited crystallographic orientation of nucleation on nano titania particle, forming the composite particles with titania being partially enwrapped with HA. Microstructural characterization by high res- olution transmission electron microscopy revealed coherent interfacial bond of (110) and (222) planes of HA crystal with (101) plane of anatase. The HA layer promoted significantly recruitment of Escherichia coli bacteria onto the titania-based particles for subsequent photocatalytic killing. Less extent of enwrapping of HA on titania particle, as accomplished by increasing the aging time of HA suspension, gave rise to better capability of photocatalytic degradation of methylene blue and sterilization of the bacteria. The novel HA-enwrapped titania powder shows great potential for environmental applications.
分类： 光学 >> 量子光学 提交时间： 2023-02-19
摘要： Optical tweezers can manipulate tiny particles. However, the distortion caused by the scattering medium restricts the applications of optical tweezers. Wavefront shaping techniques including the transmission matrix (TM) method are powerful tools to achieve light focusing behind the scattering medium. In this paper, we propose a new kind of TM, named intensity transmission matrix (ITM). Only relying on the intensity distribution, we can calculate the ITM with only about 1/4 measurement time of the widely used four-phase method. Meanwhile, ITM method can avoid the energy loss in diffraction introduced by holographic modulation. Based on the ITM, we have implemented particle manipulation with a high degree of freedom on single and multiple particles. In addition, the manipulation range is enlarged over twenty times (compared with the memory effect) to 200 {\mu}m.
分类： 生物学 >> 生物物理学 提交时间： 2016-05-12
摘要： We report on thrombolysis acceleration of a nanomachine powered by light-driving delta-subunit-free F0F1-ATPase motor. It is composed of a mechanical device, locating device, energy storage device, and propeller. The rotory delta-subunit-free F0F1-ATPase motor acts as a mechanical device, which was obtained by reconstructing an original chromatophore extracted from Rhodospirillum rubrum. We found that the bioactivity of the F0F1-ATPase motor improved greatly after reconstruction. The zeta potential of the nanomachine is about -23.4 mV. Cytotoxicity induced by the nanomachine was measured using cell counting kit (CCK)-8 assay. The A549 cells incubated with different fractional concentrations of the nanomachine within 48 h did not show obvious cytotoxicity. The locating device helps the nanomachine bind to the thrombi. Energy was easily stored by exposing the nanomachine to 600-nm-wavelength irradiation, which promoted activity of the motor. The rotation of the long propeller accelerated thrombolysis of a blood clot in vitro in the presence of urokinase (UK). This result was based on visual inspection and confirmed by a series of tests.
分类： 天文学 >> 天文学 提交时间： 2023-02-19
摘要： Deep learning techniques have been well explored in the transiting exoplanet field; however, previous work mainly focuses on classification and inspection. In this work, we develop a novel detection algorithm based on a well proven object detection framework in the computer vision field. Through training the network on the light curves of the confirmed Kepler exoplanets, our model yields about 90% precision and recall for identifying transits with signal-to-noise ratio higher than 6 (set the confidence threshold to 0.6). Giving a slightly lower confidence threshold, recall can reach higher than 95%. We also transfer the trained model to the TESS data and obtain similar performance. The results of our algorithm match the intuition of the human visual perception and make it useful to find single-transiting candidates. Moreover, the parameters of the output bounding boxes can also help to find multiplanet systems. Our network and detection functions are implemented in the Deep-Transit toolkit, which is an open-source Python package hosted on GitHub and PyPI.
分类： 天文学 >> 天文学 提交时间： 2023-02-19
摘要： Lobster eye telescopes are ideal monitors to detect X-ray transients, because they could observe celestial objects over a wide field of view in X-ray band. However, images obtained by lobster eye telescopes are modified by their unique point spread functions, making it hard to design a high efficiency target detection algorithm. In this paper, we integrate several machine learning algorithms to build a target detection framework for data obtained by lobster eye telescopes. Our framework would firstly generate two 2D images with different pixel scales according to positions of photons on the detector. Then an algorithm based on morphological operations and two neural networks would be used to detect candidates of celestial objects with different flux from these 2D images. At last, a random forest algorithm will be used to pick up final detection results from candidates obtained by previous steps. Tested with simulated data of the Wide-field X-ray Telescope onboard the Einstein Probe, our detection framework could achieve over 94% purity and over 90% completeness for targets with flux more than 3 mCrab (9.6 * 10-11 erg/cm2/s) and more than 94% purity and moderate completeness for targets with lower flux at acceptable time cost. The framework proposed in this paper could be used as references for data processing methods developed for other lobster eye X-ray telescopes.
分类： 天文学 >> 天文学 提交时间： 2023-02-19
摘要： Lobster eye telescopes are ideal monitors to detect X-ray transients, because they could observe celestial objects over a wide field of view in X-ray band. However, images obtained by lobster eye telescopes are modified by their unique point spread functions, making it hard to design a high efficiency target detection algorithm. In this paper, we integrate several machine learning algorithms to build a target detection framework for data obtained by lobster eye telescopes. Our framework would firstly generate two 2D images with different pixel scales according to positions of photons on the detector. Then an algorithm based on morphological operations and two neural networks would be used to detect candidates of celestial objects with different flux from these 2D images. At last, a random forest algorithm will be used to pick up final detection results from candidates obtained by previous steps. Tested with simulated data of the Wide-field X-ray Telescope onboard the Einstein Probe, our detection framework could achieve over 94% purity and over 90% completeness for targets with flux more than 3 mCrab (9.6 * 10-11 erg/cm2/s) and more than 94% purity and moderate completeness for targets with lower flux at acceptable time cost. The framework proposed in this paper could be used as references for data processing methods developed for other lobster eye X-ray telescopes.
分类： 计算机科学 >> 计算机科学的集成理论 提交时间： 2024-07-09
摘要： We provide an efficient $ O(n^2) $ implementation for solving the all pairs minimax path problem or widest path problem in an undirected dense graph. It is a code implementation of the Algorithm 4 (MMJ distance by Calculation and Copy) in a previous paper. The distance matrix is also called the all points path distance (APPD). We conducted experiments to test the implementation and algorithm, compared it with several other algorithms for solving the APPD matrix. Result shows Algorithm 4 works good for solving the widest path or minimax path APPD matrix. It can drastically improve the efficiency for computing the APPD matrix. There are several theoretical outcomes which claim the APPD matrix can be solved accurately in $ O(n^2) $ . However, they are impractical because there is no code implementation of these algorithms. It seems Algorithm 4 is the first algorithm that has an actual code implementation for solving the APPD matrix of minimax path or widest path problem in $ O(n^2) $, in an undirected dense graph.
分类： 计算机科学 >> 计算机科学的集成理论 提交时间： 2024-06-18
摘要： A new index for internal evaluation of clustering is introduced. The index is defined as a mixture of two sub-indices. The first sub-index $ I_a $ is called the Ambiguous Index; the second sub-index $ I_s $ is called the Similarity Index. Calculation of the two sub-indices is based on density estimation to each cluster of a partition of the data. An experiment is conducted to test the performance of the new index, and compared with six other internal clustering evaluation indices -- Calinski-Harabasz index, Silhouette coefficient, Davies-Bouldin index, CDbw, DBCV, and VIASCKDE, on a set of 145 datasets. The result shows the new index significantly improves other internal clustering evaluation indices.
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