Subjects: Medicine, Pharmacy >> Preventive Medicine and Hygienics submitted time 2024-02-19 Cooperative journals: 《中国全科医学》
Abstract: Diarrhea-Predominant Irritable Bowel Syndrome(IBS-D)is a clinically common functional gastrointestinal disease,in which immune imbalance plays an important role. Related immune cells include innate immune cells and adaptive immune cells,and immune cytokines include immunoglobulin,interferon,interleukin,tumor necrosis factor,etc. Traditional Chinese medicine monomers/compounds or compound formulas can regulate immunotherapy for IBS-D through multi-pathway,multi-target. This article systematically reviews and sorts out relevant literature on targeted immunotherapy of IBS-D using traditional Chinese medicine monomers/compounds and compound therapies from the perspectives of immune imbalance and intestinal infection,dysbiosis of flora,brain-gut axis disorder,and endocrine disorders. At the same time,it confirms the similarities between the "spleen as the guard" and immunity,to provide ideas for traditional Chinese medicine to treat IBS-D and related diseases through immune-mediated pathways.