宫颈低度鳞状上皮内瘤变与Ki-67阳性指数的相关性 postprint

Abstract: Objective To explore correlation of cervical low-alcohol intraepithelial neoplasia (CIN I) with positive index Ki-67.Methods A total of 100 patients with cervical hypothelial neoplasm were diagnosed of cervical biopsy in our hospital. Theimmunohistochemical ki-67 was detected with no treatment. The histopathological biopsy and immunohistochemical detectionki-67 were examined in 6 months. The pathologic biopsy and immunohistochemical ki-67 results were compared. Results Inthe first cervical biopsy, 100 patients were diagnosed of CIN Ⅰ. The ki-67 positive index was detected. According to thepositivity rate, 100 cases of CIN Ⅰ were divided into 3 Ki-67 ranges:88 cases were less than 3%, 10 cases in 3%~10% and 2 caseswere more than 10% (P<0.05). Patients with a positive rate less than 3% in the second biopsy showed no progress of disease.Eight cases in 3%~10% were developed for CIN Ⅱ. 2 cases in group of more than 10% were developed for CIN Ⅲ. Conclusion Ki-67 positive index can decide the cervical low-alcohol intraepithelial neoplasia outcome of patients. The high positive indexmake it develop for CIN II or CIN III.