羊膜腔穿刺对母婴HBV垂直传播的meta分析 postprint

Abstract: Objective To explore if amniocentesis in pregnant with HBV infection carriers will increase the risk of mother-to-child transmission(MTCT). Methods All relevant published papers and abstracts of English and Chinese were searched by thekey words such as hepatitis B virus/HBV, amniocentesis, vertical/mother-to-child transmission in Pubmed (MEDLINE),Embase, Google scholar and Wanfang database between January 1 1990 and March 15 2016. Four papers with 3997 pregnantwomen including 167 amniocentesis cases and 3830 control cases were entered to this analysis. The analysis was performed bystatistical software Review Manager Version 5.0. Results The meta-analysis showed that there was no significant difference ofinfant’s HBs Ag-positive rate between two groups of mothers who underwent amniocentesis or no amniocentesis (R2=1.37, 95%CI: 0.70~2.69, P=0.36). It increased the risk of MCTC of HBV if amniocentesis was performed in pregnant women with serumHBV-DNA≥107 copies/m L (R2=9.54, 95% CI: 3.52~25.85, P<0.0004) and/or HBe Ag-positivity (R2=3.41, 95% CI: 1.05~11.13,P=0.04). Conclusion Amniocentesis in pregnant women with serum HBV-DNA ≥107 copies/m L and/or HBe Ag-positivitywould increase the risk of MTCT in HBV infection.