Efficient removal of uranium from mice by a novel compound of fullerence multi-macrocyclic polyamine derivatives

分类： 核科学技术 >> 核材料与工艺技术 提交时间： 2023-06-18 合作期刊: 《Nuclear Science and Techniques》

LIU Xiao-Qing YANG Yuan-You LIAO Jia-Li OU Wei KONG Fang LAN Jing-Bo LUO Shun-Zhong LIU Guo-Ping HE Jia-Heng YANG Ji-Jun TANG Jun LIU Ning

摘要： Uranium removal efficacy of fullerence multi-macrocyclic polyamine derivatives (C60-MMP), a novel chelating agent, was evaluated in mice. C60-MMP was administrated intravenously into mice at 30 min after the uranium contamination. The molar ratio of chelating ligand/uranium was about 1:1. The results indicate that C60-MMP can effectively prevent accumulation of uranium in liver at 8 h after C60-MMP injection. At 48 h after the last injection, uranium deposition in liver of C60-MMP treated mice is approximately 65% less than that of the control group. C60-MMP reacted positively in promoting the removal of uranium from kidney, and the urinary uranium excretion increased significantly, compared with the control and DTPA-treated mice. However, repeated administration of C60-MMP, and combined injection of DTPA and C60-MMP, did not show desirable effects on uranium removal from mice. It implies that more investigations are needed for the treatment protocols and clinical applications of C60-MMP.

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