Efficient removal of uranium from mice by a novel compound of fullerence multi-macrocyclic polyamine derivatives

摘要: Uranium removal efficacy of fullerence multi-macrocyclic polyamine derivatives (C₆₀-MMP), a novel chelating agent, was evaluated in mice. C₆₀-MMP was administrated intravenously into mice at 30 min after the uranium contamination. The molar ratio of chelating ligand/uranium was about 1:1. The results indicate that C₆₀-MMP can effectively prevent accumulation of uranium in liver at 8 h after C₆₀-MMP injection. At 48 h after the last injection, uranium deposition in liver of C₆₀-MMP treated mice is approximately 65% less than that of the control group. C₆₀-MMP reacted positively in promoting the removal of uranium from kidney, and the urinary uranium excretion increased significantly, compared with the control and DTPA-treated mice. However, repeated administration of C₆₀-MMP, and combined injection of DTPA and C₆₀-MMP, did not show desirable effects on uranium removal from mice. It implies that more investigations are needed for the treatment protocols and clinical applications of C₆₀-MMP.