分类： 核科学技术 >> 核探测技术与核电子学 提交时间： 2023-06-18 合作期刊: 《Nuclear Science and Techniques》
摘要： With a Geant4 software package based on the Monte Carlo method, a multi-cell 4 detection system is designed, which consists of 40 Gadolinium-loaded liquid scintillation detectors. These detectors, associated with a fission chamber in its geometrical center, constitute a platform. This platform is mainly used for the measurement of a fissionable nucleus (n, 2n) reaction cross section. In order to properly determine the experimental set-up, we carry out a systematic numerical simulation using our model which is established by the Geant4 software package. This work provides rich and valuable reference data for experiments on the fissionable nucleus (n, 2n) cross section measurement in the future.
分类： 医学、药学 >> 药学 提交时间： 2022-12-26
Chen-yu Wang
Di-hong Yang
Xiao-min Niu
Lu Han
Wen Wang
Roman Filimonov
Sajid Ali Shah
Xin-yang Weng
Zheng Jiao
摘要： 目的：在非小细胞肺癌患者中，免疫检查点抑制剂联合化疗方案比传统化疗方案为患者提供了更多获益。然而，依然有部分患者无法得到获益，存在着免疫耐受的现象。临床可测量的生物标志物是预测临床结果和优化剂量策略所必需的。本研究旨在通过定量系统药理学（QSP）研究可获得的生物标志物，这些生物标志物可以预测非小细胞肺癌患者的临床结果，并优化atezolizumab和nab紫杉醇联合治疗的给药策略。 方法：使用MATLAB中的SimBiology工具箱，基于已发表的三阴性乳腺癌QSP模型开发该模型。利用该模型，我们生成了一个虚拟患者队列以进行虚拟临床试验模拟，并使用来自真实临床试验（IMpower131）的数据进行模型校准和验证。 结果：最终QSP模型预测与临床报告的疗效终点一致。患者的肿瘤中基线CD8+和CD4+T细胞密度与临床获益显著相关。Roc分析进一步揭示了它们作为联合治疗方案的预测生物标志物的潜力。虚拟临床试验模拟显示，将nab紫杉醇剂量从100 mg/m2降至75 mg/m2将导致ORR降低，但依然高于atezolizumab单药治疗。三种atezolizumab给药策略联合nab紫杉醇显示出相似的疗效。 结论：本研究提供了一个QSP模型，可用于生成虚拟患者队列并进行虚拟临床试验。我们的研究结果证明了它在预测免疫疗法和化疗的疗效、识别预测性生物标志物以及指导未来临床试验设计方面的潜力。
分类： 物理学 >> 核物理学 提交时间： 2024-03-04
Fang-Lei Zou
Xiao-Jun Sun
Jing-Shang Zhang
Hai-Rui Guo
Yin-Lu Han
Rui-Rui Xu
Xi Tao
Ji-Min Wang
Xiao-Dong Sun
Yuan Tian
Tao Ye
Yong-Li Xu
Chun-Tian Liang
摘要： Based on the unified Hauser–Feshbach and exciton model, which can describe the particle emission processes between discrete energy levels with energy, angular momentum, and parity conservations, a statistical theory of light nucleus reaction (STLN) is developed to calculate the double-differential cross-sections of the outgoing neutron and light charged particles for the proton-induced 6Li reaction. A significant difference is observed between the p + 6Li and p + 7Li reactions owing to the discrepancies in the energy-level structures of the targets. The reaction channels, including sequential and simultaneous emission processes, are analyzed in detail. Taking the double-differential cross-sections of the outgoing proton as an example, the influence of contaminations (such as 1H, 7Li, 12C, and 16O) on the target is identified in terms of the kinetic energy of the first emitted particles. The optical potential parameters of the proton are obtained by fitting the elastic scattering differential cross-sections. The calculated total double-differential cross-sections of the outgoing proton and deuteron at Ep = 14 MeV agree well with the experimental data for different outgoing angles. Simultaneously, the mixed double differential cross-sections of 3He and α are in good agreement with the measurements. The agreement between the measured data and calculated results indicates that the two-body and three-body breakup reactions need to be considered, and the pre-equilibrium reaction mechanism dominates the reaction processes. Based on the STLN model, a PLUNF code for the p + 6Li reaction is developed to obtain an ENDF-6-formatted file of the double-differential cross-sections of the nucleon and light composite charged particles.
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