Subjects: Library Science，Information Science >> Library Science submitted time 2023-10-08 Cooperative journals: 《知识管理论坛》
Abstract： [Purpose/significance] Academicians are the main and elite force to promote the development of science and technology in China, the research on its growth rule and development history has great significance for the discovery and cultivation of talents in China. [Method/ process] By the CV analysis method, this paper comprehensively collected information on academicians, and carried out the quantitative research on the temporal and spatial characteristics, academic structure characteristics of the academician group. [Result/conclusion] This paper explores the basic characteristics and the factors affecting the achievement of academician group. Then, it puts forward the rationalization suggestions for talent training in the new era.
Subjects: Environmental Sciences, Resource Sciences >> Basic Disciplines of Environmental Science and Technology submitted time 2023-08-07
Abstract： Organic carbon burial is an important part of the carbon cycle, but there are few studies on organic carbon in coral reef sediments, which affects the accurate assessment of coral reef carbon cycle. In this paper, the modern surface sediments from the outer slope of Yongle Atoll, Xisha Islands, South China Sea, were analyzed for their total organic carbon (TOC) content, total nitrogen (TN) content, organic carbon isotope (δ13C) value, as well as sediment grain size, chlorophyll content and other indicators. The ecological condition of the outer slope of Yongle Atoll reef is relatively good, and has the potential to represent the organic carbon characteristics in sediments of healthy coral reef ecosystems. The results showed that: 1) the TOC content in the sediments from the outer slope of Yongle Atoll reef ranged from 0.71 to 1.66 mg·g-1, with an average of 1.23±0.31 mg·g-1; the TN content ranged from 0.12 to 0.28 mg·g-1, with an average of 0.20±0.05 mg·g-1. 2) the C/N ratio ranged from 6.16 to 7.59, with an average of 6.75±0.34; δ13C values ranged from -17.49 to -15.85‰, with an average of -16.61±0.49‰, indicating that the organic carbon in the sediments was predominantly of marine autochthonous origin and mainly from benthic plants. 3) Organic carbon content was negatively correlated with water depth and positively correlated with chlorophyll a content and pheophytin content, indicating that primary productivity controlled by benthic plants was the main source of organic carbon content on the outer slope of the reef. Combined with the average deposition rate of surface sediments in this area over the past 3,500 years (1.27 mm·a-1), it is hypothesized that the organic carbon burial flux on the outer slope of Yongle Atoll ranges from 1.12 to 2.61 g·m-2·a-1, with an average of 1.93±0.49 g·m-2·a-1. The present study provides new information for evaluating the contribution of coral reefs in the South China Sea to the carbon cycle.
Peer Review Status:
Awaiting Review
Subjects: Physics >> General Physics: Statistical and Quantum Mechanics, Quantum Information, etc. submitted time 2023-07-04 Cooperative journals: 《中国全科医学》
Abstract： Coronary microvascular dysfunction（CMD）and metabolic syndrome（MetS）have attracted much attention recently due to the adverse effects on cardiovascular system. CMD is a potential factor leading to myocardial ischemia，which is closely related to the occurrence，progression and poor prognosis of cardiovascular diseases. MetS is a group of metabolic diseases caused by a combination of genetic and environmental factors. There is an association between CMD and MetS， understanding the complex interactions between the two diseases is essential for developing effective prevention and treatment strategies. This article aims to review the development of MetS and CMD，and the relationship of the components of MetS with CMD，as well as the diagnosis，treatment and future research directions of these diseases.
Subjects: Library Science，Information Science >> Information Science submitted time 2023-04-01 Cooperative journals: 《图书情报工作》
Abstract： [Purpose/significance] This paper aims to explain the development of international information literacy and provides reference for domestic development. [Method/process] Based on the literature in SCI、SSCI with the subject of information literacy, this paper used bibliometric method for analysis, and focused on the conceptual literatures in the analysis results. [Result/conclusion] The information literacy development process is divided into 4 stages(1970s,1980s,1990s-2004,2004-present),and two paradigms(information literacy1.0 and information literacy2.0) according to information landscape, technology, information literacy connotation, framework, educational philosophy and practice chronologically. Guided by social constructivism and connectivism, information literacy2.0 extends the context from education to work and daily life, and extends from a set of individual skills to collaborative social practice including cognitive, metacognitive, emotional, attitude factors and so on. In higher education, information literacy education expands from source approach, technical approach, behavioral approach, process approach to more emphasis on process approach, communication approach and threshold concepts.
Subjects: Geosciences >> Geography submitted time 2022-12-14 Cooperative journals: 《干旱区研究》
Abstract：
The arid regions of Central Asia, which are“upstream”of China in terms of their influence on weather and climate, are characterized by a general shortage of water resources and the fragility of ecosystems. The atmospheric water cycle is the key link in the transformation of water resources and ecosystems in this region. In this study, we reassessed the temporal and spatial variation of water cycle elements, such as atmospheric water vapor content, water vapor budget, precipitation, and actual evaporation, in the arid region and subregions of Central Asia, from 1979 to 2018. The results of our analysis show clear spatial differences in the water cycle elements of Central Asia. Precipitation and actual evaporation are high in mountainous areas, such as Tianshan Mountains and Pamir and surrounding oasis areas, and low in the desert plain areas, whereas atmospheric water vapor content shows an opposite pattern. In terms of temporal changes, from 1979 to 2018, the water vapor content in Central Asia showed a weak decreasing trend, with obvious regional differences in the rate of change. Water vapor content in the surrounding areas of the Aral Sea decreased significantly, whereas in most of the areas of the Xinjiang and Tianshan Mountains, it increased significantly. Zonal transport is the main mode of water vapor transport in Central Asia, compared with the relatively weak meridional transport. Large differences were found in the water vapor budget over different regions; the water vapor transport tended to decrease in the western and northern boundaries and increased in the eastern and southern boundaries. Water vapor revenue and expenditure showed an increasing trend in northwestern Central Asia, southern Central Asia, the Pamir Plateau, and the Tianshan Mountains and a decreasing trend in northern Central Asia and most of Xinjiang. In contrast to the change in water vapor transport, the precipitation in Central Asia increased from 1979 to 2018, with an increase of 4.14 mm·(10a)-1 and a large interannual fluctuation. The significant increasing trend of precipitation is distributed in northern Central Asia and most of the Xinjiang and Tianshan Mountains, whereas there was a significant decreasing trend in northwestern and southern Central Asia. The actual evaporation in Central Asia showed a slight increasing trend, increasing significantly in the northern part of Central Asia, the Tianshan Mountains, and Pamir but decreasing significantly in the Caspian Sea area, Aral Sea, southern Central Asia, and southern Xinjiang. In terms of seasonal variation, the temporal and spatial distribution of seasonal and annual variations of water cycle elements was generally consistent. The results of our analysis contribute to a better understanding of the evolution and mechanism of the atmospheric water cycle in the arid regions of Central Asia.
Subjects: Medicine, Pharmacy >> Pharmacology submitted time 2021-07-12
Abstract： Tumor angiogenesis is a hallmark of cancer. Therapeutic drug inhibitors targeting angiogenesis are clinically effective. We have previously identified GT198 (gene symbol PSMC3IP, also known as Hop2) as an oncoprotein that induces tumor angiogenesis in human cancers, including oral cancer. In this study, we show that GT198 protein is a direct drug target of more than a dozen oncology drugs and several clinically successful anticancer herbs. GT198 is a DNA repair protein that binds to DNA. Using an in vitro DNA-binding assay, we tested the approved oncology drugs set VII from NCI containing 129 oncology drugs. Identified GT198 inhibitors include but are not limited to mitoxantrone, doxorubicin, paclitaxel, etoposide, dactinomycin, and imatinib. Paclitaxel and etoposide have higher binding affinities, whereas doxorubicin has higher binding efficacy due to competitive inhibition. GT198 shares protein sequence homology with DNA topoisomerases, which are known drug targets, so that GT198 is likely a new drug target previously unrecognized. To seek more powerful GT198 inhibitors, we further tested several anticancer herbal extracts. The positive anticancer herbs with high affinity and high efficacy are all clinical successful ones, including allspice from Jamaica, Gleditsia sinensis or honey locust from China, and BIRM from Ecuador. Partial purification of allspice using organic chemical approach demonstrated great feasibility of natural product purification, when the activity is monitored by the in vitro DNA-binding assay using GT198 as target. Together, our study reveals GT198 as a new targeting mechanism for existing oncology drugs. The study also delivers an excellent drug target suitable for compound identification and natural product purification. In particular, this study opens an opportunity to rapidly identify drugs with high efficacy and low toxicity from nature.
Peer Review Status:Awaiting Review
Hits
YES
Hits
Downloads
Comment