• Study on the Pharmacological Mechanism of the Xihuang Pill and its Treatment of Breast Cancer Based on Nontargeted Metabonomics

    分类: 医学、药学 >> 中医学与中药学 提交时间: 2024-02-26

    摘要: Objective. To study the main differential metabolites of Xihuang Pill (XHP) in rat serum and the mechanism of related pathways of metabolites on breast cancer. Method. Qualitative and quantitative analysis of metabolites in XHP drug serum group and blank serum group by liquid chromatography-mass spectrometry (LC-MS) technology. And using sample correlation heat map and multivariate statistical analysis methods to compare the metabolic differences between the two groups. The metabolites were analyzed by cluster analysis, Variable Importance in Projection (VIP) analysis, Kyoto Encyclopedia of genes and Genomes (KEGG) compound classification and KEGG functional and enrichment topology analysis. Result. LC-MS technology identified a total of 765 metabolites in the XHP drug serum group; a total of 697 metabolites in the blank serum group. VIP analysis screened the top 30 serum differential metabolites that were significantly different between the two groups, such as Abscisic acid, Quillaic acid, 2,2-Bis(4-hydroxyphenyl)-1-propanol, Corey PG-Lactone Diol, (S)-Naproxen and so on. KEGG compound classification showed that most of the metabolites in XHP were classified as phospholipids and amino acids, steroid hormones and carboxylic acids . KEGG functional pathways main involved are Lipid metabolism, Amino acid metabolism, Cancer: overview. KEGG enrichment and topology analysis, mainly involved in steroid hormone biosynthesis pathway and beta-alanine metabolism pathway. Conclusion. The main differential metabolite of XHP in rat serum may be Abscisic acid. XHP may exert its pharmacological effect on breast cancer by regulating steroid hormone biosynthesis pathway to regulate estrogen and progesterone levels and beta-alanine metabolism pathway to induce cancer cell apoptosis.

  • Free-space point-to-multiplepoint optical frequency transfer with lens assisted integrated beam steering

    分类: 光学 >> 量子光学 提交时间: 2023-02-19

    摘要: We report on the realization of high-performance silica integrated two-dimensional lens assisted beam-steering (LABS) arrays along with the first-of-their-kind point-to-multiplepoint optical frequency transfer. {The LABS equips with $N$ antennas} and has the capability to produce arbitrary number of output beams with different output angles with the simple control complexity. We demonstrate that the LABS has 16 scanning angles, which can support {the access capability for the maximum of simultaneous 16 user nodes.} The coaxial configuration for transmitting and receiving the light as a monolithic transceiver allows us to reduce the out-of-loop phase noise significantly. Finally, the LABS-based non-blocking point-to-multiplepoint in-door free-space optical frequency transfer links with 24 m and 50 m free-space links are shown. After being compensated for the free-space link up to 50 m, the fractional frequency instability of $4.5\times10^{-17}$ and $7.7\times10^{-20}$ at the averaging time of 1 s and 20,000 s, respectively, can be achieved. The present work proves the potential application of the 2D LABS in free-space optical time-frequency transfer and provides a guidance for developing a chip-scale optical time-frequency transfer system.