摘要: The human influenza A (H3N2) virus dominated the 2014-2015 winter season in many countries and caused massive morbidity and mortality because of its antigenic variation. So far, very little is known about the antigenic patterns of the recent H3N2 virus. By systematically mapping the antigenic relationships of H3N2 strains isolated since 2010, we discovered that two groups with obvious antigenic divergence, named SW13 (A/Switzerland/9715293/2013-like strains) and HK14 (A/Hong Kong/5738/2014-like strains), co-circulated during the 2014-2015 winter season. HK14 group co-circulated with SW13 in Europe and the United States during this season, while there were few strains of HK14 in mainland China, where SW13 has dominated since 2012. Furthermore, we found that substitutions near the receptor-binding site on hemagglutinin played an important role in the antigenic variation of both the groups. These findings provide a comprehensive understanding of the recent antigenic evolution of H3N2 virus and will aid in the selection of vaccine strains.
-
期刊:
SCIENCE CHINA-LIFE SCIENCES
-
分类:
生物学
>>
生物物理学
>>
生物力学与生物流变学
-
引用:
ChinaXiv:201605.01472
(或此版本
ChinaXiv:201605.01472V1)
DOI:10.12074/201605.01472V1
CSTR:32003.36.ChinaXiv.201605.01472.V1
- 推荐引用方式:
Hua Sha,Liu Mi,Wu AiPing,Jiang TaiJiao,Hua Sha,Liu Mi,Li XiYan,Cheng YanHui,Huang WeiJuan,Tan MinJu,Wei HeJiang,Guo JunFeng,Wang DaYan,Shu YueLong,Peng YouSong,Jiang TaiJiao,Wu AiPing,Jiang TaiJiao,Wu AiPing,Jiang TaiJiao,Wu AiPing,Jiang TaiJiao.(2016).Antigenic variation of the human influenza A (H3N2) virus during the 2014-2015 winter season.中国科学院科技论文预发布平台.[ChinaXiv:201605.01472]
(点此复制)