Prognostic significance of interim ¹⁸F-FDG PET/CT SUV reduction associated with Ki67 in patients with diffuse large B-cell lymphoma

分类： 核科学技术 >> 核材料与工艺技术 提交时间： 2023-06-18 合作期刊: 《Nuclear Science and Techniques》

SUN Yi-Wen ZHAO Jin-Hua QIAO Wen-Li XING Yan CHEN Xiang SONG Jian-Hua

摘要： To detect the prognostic significance of interim 18F-FDG PET/CT SUV (standard uptake value) reduction (SUVmax) associated with Ki67 in patients with diffuse large B cell lymphoma (DLBCL). 47 DLBCL patients underwent PET/CT before initiation and after 24 cycles of chemotherapy were included. The SUVmax of the dominant lesions were calculated. Ki67 positive indices were provided by enzyme-labeled immuno-histochemistry. SPSS17.0 was used for statistical analysis. SUVmax of different groups were compared by t test. Receiver-operator characteristic analysis was performed to determine the optimal cutoff values. Kaplan-Meier analyses of PFS (Progression-free survival) were compared using log-rank test. The average of SUVmax and SUVmax% were 11.53 and 69.10%, respectively. The optimal cutoff values of SUVmax and SUVmax% were 11.45 and 82.92%, respectively. Higher SUVmax and SUVmax% indicated longer PFS (p55% was revealed to be an indicator of shorter PFS (p=0.019). Either SUVmax11.45 or Ki67>55% was defined as an indicator to poor outcome and scored 1 point. The PFS rate was 100% in patients scored 0 point, yet 0% in patients scored 2 points. PFS tended to be shorter along with the score getting higher (p=0.006). SUVmax and Ki67 positive index were both of significance in DLBCL prognosis. The prognostic value may be confirmed when SUVmax was accordant with Ki67.

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