分类: 地球科学 >> 空间物理学 提交时间: 2017-01-22
摘要: The miniature design technology is an important trend in space exploration. Mass spectrometer is used extensively in the space environment detection. The miniature ion mass spectrometer utilizes a 127�cylindrical electrostatic analyzer accompanied with a Time of Flight(TOF) unit based on ultrathin carbon foil to measure the energy spectra and composition of space plasma. The Time of Flight technique has been used broadly in space plasma measurement. A new type of miniature method for the ion mass spectrometer is introduced. The total mass of the instrument is 1.8 kg and the total power consumption is 2.0 W. The calibration results show that the energy measurement range is 8.71~43550eV, the energy resolution is 1.86% and the ion mass from 1 amu(1 amu =1.67 x 10~(-27) kg) to 58 amu can be resolved by the miniature mass spectrometer. The miniature ion mass spectrometer also has a potential to be increased in the field of view by an electrostatic deflecting system to extend its application in space plasma detection. The miniature ion mass spectrometer has been selected for pre-study of Chinese Strategic Priority Research Program on Space Science.
分类: 生物学 >> 生物物理学 >> 细胞生物学 提交时间: 2016-05-12
摘要: The H3 histone variant CENP-A is an epigenetic marker critical for the centromere identity and function. However, the precise regulation of the spatiotemporal deposition and propagation of CENP-A at centromeres during the cell cycle is still poorly understood. Here, we show that CENP-A is phosphorylated at Ser68 during early mitosis by Cdk1. Our results demonstrate that phosphorylation of Ser68 eliminates the binding of CENP-A to the assembly factor HJURP, thus preventing the premature loading of CENP-A to the centromere prior to mitotic exit. Because Cdk1 activity is at its minimum at the mitotic exit, the ratio of Cdk1/PP1 alpha activity changes in favor of Ser68 dephosphorylation, thus making CENP-A available for centromeric deposition by HJURP. Thus, we reveal that dynamic phosphorylation of CENP-A Ser68 orchestrates the spatiotemporal assembly of newly synthesized CENP-A at active centromeres during the cell cycle.