分类: 物理学 >> 普通物理:统计和量子力学,量子信息等 提交时间: 2017-05-02
摘要: The free piston energy converter (FPEC) is a new type of power unit for hybrid electric vehicle. In a FPEC, an internal combustion engine driven permanent magnet linear generator (PMLG) may be utilized to produce electrical energy. This paper discusses the issues that are pertinent to the design of a linear permanent magnet generator for application in a FPEC. To achieve the required high power density and low moving mass, a tubular machine equipped with modular windings and axially magnetized is considered to be the most appropriate. Finite Element Analysis are adopted to analyse the PMLG. Magnetic field distribution, EMF, thrust force and No- load corl loss are obtained through the finite element method. An effective tool for design optimization is provided. It is shown that the machine design can be optimized with respect to three key dimensional ratios while satisfying other performance specifications.
分类: 生物学 >> 生态学 提交时间: 2017-11-17
摘要: Chimeric antigen receptor (CAR) T-cell immunotherapies have shown unprecedented success in treating leukemia but limited clinical efficacy in solid tumors. Here, we generated 1928zT2 and m28zT2, targeting CD19 and mesothelin, respectively, by introducing the Toll/interleukin-1 receptor domain of Toll-like receptor 2 (TLR2) to 1928z and m28z. T cells expressing 1928zT2 or m28zT2 showed improved expansion, persistency and effector function against CD19+ leukemia or mesothelin+ solid tumors respectively in vitro and in vivo. In a patient with relapsed B-cell acute lymphoblastic leukemia, a single dose of 5 * 104/kg 1928zT2 T cells resulted in robust expansion and leukemia eradication and led to complete remission. Hence, our results demonstrate that TLR2 signaling can contribute to the efficacy of CAR T cells. Further clinical trials are warranted to establish the safety and efficacy of this approach.Leukemia advance online publication, 25 August 2017; doi:10.1038/leu.2017.249.