西印度醋栗的化学成分及生物活性研究进展

Subjects: Biology >> Botany >> Applied botany submitted time 2021-04-13 Cooperative journals: 《广西植物》

胥佳 李娜 朱宏涛 杨为农 王东 杨崇仁 张颖君

Abstract： Phyllanthus acidus, an evergreen shrub or tree in Euphorbiaceae, is mainly distributed in Thailand, Vietnam, Myanmar, Laos, etc. It is also introduced and cultivated in Xishuangbanna and Yuanjiang areas of Yunnan Province, China. The fruits are edible and the plant has been widely used to treat various diseases, such as hypertension, asthma, diabetes, dermatitis, fever, smallpox, and so on, by the local people of its growing areas. Moreover，the young leaves are utilized as edible vegetables in Indonesia, Thailand, and India. Phytochemical studies yielded sesquiterpenes, diterpenes and triterpenes from the roots and stems, and flavonoids as the major chemical constituents from the leaves. Some components showed obvious anti-hepatitis B virus (HBV), antibacterial, anti-inflammatory, hepatoprotective, and anti-hypertensive activities. For example, parts of the norbisabolane sesquiterpenes displayed potential anti HBV activities, with IC50 values of 0.8-36 mol·L-1 against HBV surface antigen (HBsAg) and HBV excreted antigen (HBeAg), and the results indicated that the ketal group at C-5 and sugar moieties at C-13 played important roles to the selectivity of HBsAg and HBeAg. This paper reviewed the research progress of chemical constituents and pharmacological activities of the plant from 1966 to 2020, in order to provide scientific evidence and reference for its future study, spread, application and development.

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