Subjects: Nuclear Science and Technology >> Nuclear Materials and Techniques submitted time 2023-06-18 Cooperative journals: 《Nuclear Science and Techniques》
Abstract： Pulse radiolysis studies of the reactions between balofloxacin (BFX) and eaq‒ , hydroxyl radical (˙OH), and N3· were carried out to investigate the photosensitive toxicity of BFX. The BFX radical anion formed in the reaction of BFX with eaq‒ was located at 380 nm. The transient species formed in the reaction of BFX with ˙OH radical were located in the region of 370 nm to 580 nm, with a maximum λmax at 390 nm. The BFX radical cation was obtained by reacting BFX with N3˙, and showed an absorption band at around 365 nm. The UV-Vis absorption of the BFX was found to be clearly dependent on pH. The pKa value of BFX was estimated to be 6.0±0.2. Under neutral conditions, the rate constants of BFX reacting with N3˙ and eaq‒ were determined to be 1.3×1010 dm3·mol‒1·s‒1 and 1.4×1010 dm3·mol‒1·s‒1, respectively.
Subjects: Nuclear Science and Technology >> Nuclear Materials and Techniques submitted time 2023-06-18 Cooperative journals: 《Nuclear Science and Techniques》
Abstract： A pulse radiolysis study was carried out to investigate the radical anion and radical cation of sparfloxacin (SPAX). The reactions of SPAX with hydrate electron (eaq‒), hydroxyl radical (·OH) and azide radical (·N3‒) were investigated in this study. The transient absorption spectra of SPAX radical anion and SPAX radical cation were obtained. Two transient rate constants 2.2×1010 dm3·mol‒1·s‒1 and 1.7×1010 dm3·mol‒1·s‒1 for the reactions of SPAX with eaq‒ and ·OH were determined, respectively. Finally, based on the results obtained in this study, rational mechanisms of transient reactions were proposed.
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