Subjects: Statistics >> Social Statistics submitted time 2023-12-04 Cooperative journals: 《中国科学院院刊》
Abstract： Since it was proposed, in vitro human embryo research had been following the 14-day rule, which limited in vitro research on human embryos within 14 days after fertilization. With the advancement in embryo culturing technology, this ethical rule has been greatly challenged. In 2021, the International Society for Stem Cell Research (ISSCR) recommended a conditional extension of the existing time limit in ISSCR Guidelines for Stem Cell Research and Clinical Translation, hence the international scientific community has restarted the debate on the 14-day rule. This study systematically analyzed the historical background and controversies of the 14- day rule ethical regulation of human embryo research, as well as revisited the core ethical issues of the moral status, dignity, and legal status of human embryos as research subjects. It also comprehensively examined the attitudes of different stakeholders in responding to the relaxation of current regulations and raised policy agenda and suggestions in extending the time limit of human embryo research.
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