Subjects: Chemistry >> Nuclear Chemistry submitted time 2024-06-18
Abstract： As an advanced radiation therapy technique, proton therapy is valued for its precise dose distribution and minimized damage to surrounding normal tissues. However, accurate dosimetry of proton beams is crucial to ensure treatment efficacy and safety. Fiber optic dosimeters have become a hotspot for proton therapy dosimetry research due to their unique advantages, such as high spatial resolution, real-time monitoring capability, water-equivalence, and resistance to electromagnetic interference. Based on this, this paper reviews the technical principles, current application status, development challenges and future trends of fiber optic dosimeters in proton therapy dosimetry. Firstly, this paper outlines the luminescence mechanisms of fiber optic dosimeters and describes their working principles. Then, the paper discusses the utility of fiber optic dosimeters based on different luminescence mechanisms in clinical proton therapy for high dose rate adaptability and accuracy. Meanwhile, the paper also points out the challenges and solutions to the current fiber optic dosimeter technology, such as applying scintillation quenching correction, improving time responsiveness, optimizing the data acquisition system, and enhancing the correction capability for interfering factors. Finally, the paper looks at the future of fiber optic dosimeter technology, especially its potential application in ultra-high dose rate treatments such as Flash therapy, and how existing limitations can be overcome through innovations in materials science and optoelectronic technology. Through this review, it aims to provide researchers and clinicians with a comprehensive perspective to improve the accuracy and therapeutic efficacy of proton therapy.
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