分类： 材料科学 >> 材料科学（综合） 提交时间： 2017-05-09
Sun, YN [Sun, Yuanna][ 1 ]
Liu, S [Liu, Shuang][ 1 ]
Du, GL [Du, Gaolai][ 1 ]
Gao, GR [Gao, Guorong][ 1 ]
Fu, J [Fu, Jun][ 1 ]
摘要： Multi-stimuli responsive hydrogels are synthesized using self-assembled nanomicelles of Pluronic F127 diacrylate triblock copolymer as non- covalent macro-crosslinkers to in situ copolymerize with acrylamide and methyl chloride quaternized N,N-dimethylamino ethylacrylate mono- mers, generating positively charged hydrogels. These hydrogels showed high strength, toughness, and outstanding fatigue resistance, and are reversibly responsive to changes in pH and ionic strength.
分类： 物理学 >> 普通物理:统计和量子力学,量子信息等 提交时间： 2017-05-02
Hou, RX [Hou, Ruixia][ 1 ]
Nie, L [Nie, Lei][ 1 ]
Du, GL [Du, Gaolai][ 1 ]
Xiong, XP [Xiong, Xiaopeng][ 2 ]
Fu, J [Fu, Jun][ 1 ]
摘要： This paper aims to investigate the synergistic effects of natural polysaccharides and inorganic nanopar- ticles on cell adhesion and growth on intrinsically cell non-adhesive polyvinyl alcohol (PVA) hydrogels. Previously, we have demonstrated that Fe2O3 and hydroxyapatite (nHAP) nanoparticles are effective in increasing osteoblast growth on PVA hydrogels. Herein, we blended hyaluronic acid (HA) and chondroitin sulfate (CS), two important components of cartilage extracellular matrix (ECM), with Fe2O3/nHAP/PVA hydrogels. The presence of these natural polyelectrolytes dramatically increased the pore size and the equilibrium swelling ratio (ESR) while maintaining excellent compressive strength of hydrogels. Chon- drocytes were seeded and cultured on composite PVA hydrogels containing Fe2 O3 , nHAP and Fe2 O3 /nHAP hybrids and Fe2O3/nHAP with HA or CS. Confocal laser scanning microscopy (CLSM) and cell counting kit-8 (CCK-8) assay consistently confirmed that the addition of HA or CS promotes chondrocyte adhesion and growth on PVA and composite hydrogels. Particularly, the combination of HA and CS exhibited fur- ther promotion to cell adhesion and proliferation compared with any single polysaccharide. The results demonstrated that the magnetic composite nanoparticles and polysaccharides provided synergistic pro- motion to cell adhesion and growth. Such polysaccharide-augmented composite hydrogels may have potentials in biomedical applications.
分类： 物理学 >> 普通物理:统计和量子力学,量子信息等 提交时间： 2017-05-02
Du, GL [Du, Gaolai][ 1 ]
Wu, FX [Wu, Fengxiang][ 2 ]
Cong, Y [Cong, Yang][ 2 ]
Nie, L [Nie, Lei][ 1 ]
Liu, SH [Liu, Shuhui][ 1 ]
Gao, GR [Gao, Guorong][ 1 ]
Fu, J [Fu, Jun][ 1 ]
摘要： A versatile ion release mediated by GDL is demonstrated to achieve a controlled homogeneous crosslinking of alginate chains, which is critical for the synthesis of highly stretchable and notch-insensitive hybrid hydrogels with controlled properties.
分类： 物理学 >> 普通物理:统计和量子力学,量子信息等 提交时间： 2017-05-02
Gao, GR [Gao, Guorong][ 1 ]
Du, GL [Du, Gaolai][ 1 ]
Cheng, YJ [Cheng, Yajun][ 1 ]
Fu, J [Fu, Jun][ 1 ]
摘要： Polymer hydrogels with superior strength and toughness are potential candidate materials for the replacement or engineering of load-bearing tissues. This manuscript reports novel tough nanocomposite hydrogels with an unusual energy dissipation mechanism based on both covalent and physical interactions between clay nanorods and polymer chains. Attapulgite (ATP) nanorods grafted with vinyl groups on the surface served as macro-crosslinkers to copolymerize with 2-acrylamido-2- methylpropane-sulfonic acid (AMPS) to form an initial nanocomposite network, which subsequently hosted the polymerization of acrylamide (AAm) monomers to generate a novel nanocomposite double network (DN) hydrogel. The morphology, swelling behavior and compressive properties of the ATP- grafted DN hydrogels were investigated as a function of ATP content (CATP), in comparison with the ATP-filled DN gels. With a clay content between 0.1 wt% and 1.0 wt%, the nanocomposite hydrogels did not fracture up to a compressive strain of 98%, exhibiting an initial modulus (E) up to 0.36 MPa, a compressive strength higher than 65.7 MPa, and a work to fracture (or fracture energy) higher than 2.6 MJ m 3, in comparison to 0.19 MPa, 18.6 MPa, and 1.1 MJ m 3 for the conventional DN gels. Cyclic loading–unloading tests showed abnormal residual energy dissipation even though the rigid PAMPS network had fractured. Such viscous energy dissipation decayed during cyclic loading, and could be restored depending on time and temperature. This is related to the reversible desorption–re-adsorption of polymer chains from the clay surface. Possible reinforcing and fracture mechanisms are discussed.
分类： 物理学 >> 普通物理:统计和量子力学,量子信息等 提交时间： 2017-05-02
Du, GL [Du, Gaolai][ 1 ]
Gao, GR [Gao, Guorong][ 1 ]
Hou, RX [Hou, Ruixia][ 1 ]
Cheng, YJ [Cheng, Yajun][ 1 ]
Chen, T [Chen, Tao][ 1 ]
Fu, J [Fu, Jun][ 1 ]
Fei, B [Fei, Bin][ 2 ]
摘要： Supertough biomimetic hydrogels have been fabricated through in situ synthesis and guided assembling of positively charged conjugated polymer belts by using a parent poly(2-acrylamido-2-methylpropanesulfonic acid)/poly- (acrylamide) double network (PAMPS/PAAm DN) gel template. The inter- penetrating structures of the poly(3,4-ethylenedioxythiophene) (PEDOT) belt mesh and PAMPS/PAAm host network have been confirmed by SEM, CLSM, and Raman spectroscopy. The presence of PEDOT belts improves the Young’s modulus, compressive strength, and toughness of the biomimetic (BM) hydrogels, in comparison to the parent DN gels. Cyclic tensile (300% strain) and compressive (even 90% strain) loadings demonstrate extraordinary fatigue resistance of these BM gels. Upon ten cycles, the compressive toughness remained about 1000 J m−2, which is comparable to that of articular cartilage. The internal fracture behavior and fatigue resistance of these biomimetic interpenetrating hydrogels are further investigated. These extremely tough and fatigue resistant BM hydrogels may find applications as promising substitutes for load-bearing tissues.
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